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1761por Costa Silva, Rafael Cardoso Maciel, Bandeira-Melo, Christianne, Paula Neto, Heitor Afonso, Vale, André Macedo, Travassos, Leonardo Holanda“…The major topics of this hypothesis paper are the disbalance between interferon and antibodies responses, HLA heterogeneity among the affected population, and increased proportion of cytotoxic CD4+ T cells polarization in relation to T follicular cells (Tfh) subtypes. …”
Publicado 2022
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1762“…Enrichment analysis showed that most of these genes were enriched in the interferon signalling pathway. Gene set enrichment analysis revealed that the sample was significantly enriched for expression of the interferon signalling pathway. …”
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1763“…Antiviral type I interferons (IFN) produced in the early phase of viral infections effectively inhibit viral replication, prevent virus-mediated tissue damages and promote innate and adaptive immune responses that are all essential to the successful elimination of viruses. …”
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1764por Bradley, David, Smith, Alan J., Blaszczak, Alecia, Shantaram, Dharti, Bergin, Stephen M., Jalilvand, Anahita, Wright, Valerie, Wyne, Kathleen L., Dewal, Revati S., Baer, Lisa A., Wright, Katherine R., Stanford, Kristin I., Needleman, Bradley, Brethauer, Stacy, Noria, Sabrena, Renton, David, Joseph, Joshua J., Lovett-Racke, Amy, Liu, Joey, Hsueh, Willa A.“…In human obesity, these global effects of interferon gamma to reduce regulatory T cells and diminish their function appear to instigate adipose inflammation and suppress adipocyte metabolism, leading to insulin resistance.…”
Publicado 2022
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1765“…In a recent study in Nature Immunology, Musella et al. demonstrate that suboptimal type I interferon (IFN-I) signaling in tumors undergoing immunogenic cell death (ICD) facilitates the accumulation of cancer stem cells (CSCs) by triggering the epigenetic regulator lysine demethylase 1B (KDM1B). …”
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1766
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1767“…Since the discovery of interferon-tau (IFNT) over 30 years ago as the trophectodermal cytokine responsible for the maintenance of the maternal corpus luteum (CL) in ruminants, exhaustive studies have been conducted to identify genes and gene products related to CL maintenance. …”
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1768“…Although the flaviviruses have a significant clinical impact, it has become apparent that flavivirus replication is restricted by cellular factors induced by the interferon (IFN) response, which are called IFN-stimulated genes (ISGs). …”
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1769por Jiang, Jielan, Gu, Jie, Zhan, Aijun, Mao, Mingguang, Liu, Yumeng, Wang, Haishan, Mao, Yunxiang“…Interferon γ (IFN–γ) is now considered to be one of the key molecules in the regulation of innate and adaptive immunity. …”
Publicado 2022
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1770por Koehler, Jeffrey W., Dupuy, Lesley C., Garrison, Aura R., Beitzel, Brett F., Richards, Michelle J., Ripoll, Daniel R., Wallqvist, Anders, Teh, Shia-Yen, Vaewhongs, Andrew A., Vojdani, Fakhrieh S., Padgett, Hal S., Schmaljohn, Connie S.“…Type I interferons (IFNs) are potent mediators of the innate immune response to viral infection. …”
Publicado 2011
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1771por Katami, Akinobu, Hisasue, Shin-Ichi, Sakurai, Hiromichi, Kawai, Koji, Hayashi, Yuichiro, Miyazaki, Jun“…A standard systemic therapy is not established. The efficacy of interferon-alpha (IFN-α) for GTS was described but the treatment periods were relatively short. …”
Publicado 2022
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1772por Mahittikorn, Aongart, Mala, Wanida, Masangkay, Frederick Ramirez, Kotepui, Kwuntida Uthaisar, Wilairatana, Polrat, Kotepui, Manas“…Interferon (IFN)-γ contributes to the pathogenesis of severe malaria; however, its mechanism remains unclear. …”
Publicado 2022
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1773por Baker, Simon C., Mason, Andrew S., Slip, Raphael G., Eriksson, Pontus, Sjödahl, Gottfrid, Trejdosiewicz, Ludwik K., Southgate, Jennifer“…By provoking inflammation, BCG can lead to the production of a factor called “interferon gamma” and an immune response that can eliminate the cancer. …”
Publicado 2022
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1774por Hasselbalch, Hans, Skov, Vibe, Kjær, Lasse, Larsen, Morten Kranker, Knudsen, Trine A., Lucijanić, Marko, Kusec, Rajko“…Another IFN formulation is interferon beta (IFN-β), which has been used for decades in the treatment of multiple sclerosis. …”
Publicado 2022
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1775por Pang, Zhaoxia, Hao, Pengfei, Qu, Qiaoqiao, Li, Letian, Jiang, Yuhang, Xiao, Shuqi, Jin, Ningyi, Li, Chang“…RV is one of the pathogens causing diarrhea in infants and young animals, and it induces the production of type I interferons (IFNs), which can trigger antiviral function by inducing the production of interferon–stimulated genes (ISGs). …”
Publicado 2022
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1776por Kumova, Ogan K., Galani, Ioanna-Evdokia, Rao, Abhishek, Johnson, Hannah, Triantafyllia, Vasiliki, Matt, Stephanie M., Pascasio, Judy, Gaskill, Peter J., Andreakos, Evangelos, Katsikis, Peter D., Carey, Alison J.Enlace del recurso
Publicado 2022
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1777“…Here, we report that the transcription factor interferon regulatory factor 1 (IRF1) plays critical roles in microglial activation and retinal inflammation by regulating pro- and anti-inflammatory gene expression. …”
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1778Resistance of Field-Isolated Porcine Epidemic Diarrhea Virus to Interferon and Neutralizing Antibody“…To understand the pathogenesis of the G2b PEDV, we examined the resistance of the G2b PEDV to interferon (IFN) and neutralizing antibodies, which are important for controlling PEDV infection. …”
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1779por Yamagata, Hirotaka, Tsunedomi, Ryouichi, Kamishikiryo, Toshiharu, Kobayashi, Ayumi, Seki, Tomoe, Kobayashi, Masaaki, Hagiwara, Kosuke, Yamada, Norihiro, Chen, Chong, Uchida, Shusaku, Ogihara, Hiroyuki, Hamamoto, Yoshihiko, Okada, Go, Fuchikami, Manabu, Iga, Jun-ichi, Numata, Shusuke, Kinoshita, Makoto, Kato, Takahiro A., Hashimoto, Ryota, Nagano, Hiroaki, Ueno, Shuichi, Okamoto, Yasumasa, Ohmori, Tetsuro, Nakagawa, Shin“…Pathway analysis of the RNA sequencing data for antidepressant responsiveness identified that hypercytokinemia- and interferon-related genes were increased in non-responders. …”
Publicado 2023
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1780por Ren, Xingxing, Wang, Decai, Zhang, Guorong, Zhou, Tingyue, Wei, Zheng, Yang, Yi, Zheng, Yunjiang, Lei, Xuqiu, Tao, Wanyin, Wang, Anmin, Li, Mingsong, Flavell, Richard A., Zhu, Shu“…By additional knockout MAVS or STAT1 in DHX9-deficient mice, we demonstrated that nucleic DHX9 plays a positive role in regulating interferon-stimulated gene (ISG) expression downstream of type I interferon. …”
Publicado 2023
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