“…In this article we summarise the information currently available on how these viruses are able to establish infection when confronted with a powerful antiviral interferon system.…”
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“…The current standard-of-care therapy for chronic HCV infection consists of a combination of pegylated (PEG) interferon (IFN)-α and ribavirin. Although this therapy effectively generates a sustained viral response in approximately half of treated individuals, it is associated with significant hematological and neurological side effects. …”
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“…Interferons (IFNs) are cytokines that play a key role in innate and adaptive immune responses. …”
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“…Virus infection of mammalian cells induces the production of high levels of type I interferons (IFNα and β), cytokines that orchestrate antiviral innate and adaptive immunity. …”
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“…The functional links between membrane trafficking of interferon receptors and JAK/STAT signaling have recently begun to be unraveled. …”
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“…Interferon-alpha (IFN-α) has immunoregulatory functions in autoimmune inflammatory diseases. …”
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“…We have recently discovered that the clinically established immunotherapeutic agent interferon α (IFNα) inactivates the suppressive functions of human Tregs. …”
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“…Interferons (IFNs) are a family of cytokines with potent antiproliferative, antiviral, and immunomodulatory properties. …”
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“…One factor that seems able to knit together much of this complexity is the cytokine interferon-gamma (IFN-γ). In this review we consider findings from the clinical disease, in vitro models and the murine counterpart of human cerebral malaria in order to evaluate the roles played by IFN-γ in the pathogenesis of this often fatal and debilitating condition.…”
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“…Another undesired consequence of interferon therapy is the worsening of a preexistent psychiatric disorder. …”
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“…The host interferon (IFN) response represents one of the first barriers that influenza viruses must surmount in order to establish an infection. …”
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“…One such family are the interferons (IFNs), a family of cytokines that are involved in several cellular functions. …”
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“…NSs acts as antagonist of the antiviral type I interferon (IFN) system. Recent progress in the elucidation of the molecular functions of a growing list of NSs proteins highlights the astonishing variety of strategies employed by phleboviruses to evade the IFN system.…”
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“…Focal segmental glomerulosclerosis (FSGS) is usually seen in viral infections, immune deficiency syndrome, sickle cell anemia, and hyperfiltration and secondary to interferon therapy. Here, we present a case of FSGS identified with kidney biopsy in a patient who had been diagnosed with Behçet's disease and received interferon-alpha treatment for uveitis and presented with acute renal failure and nephrotic syndrome associated with interferon.…”
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“…Inflammation is an essential physiological process, which enables survival during infection and maintains tissue homeostasis. Interferons (IFNs) and pro- and anti-inflammatory cytokines are crucial for appropriate response to pathogens, damaged cells, or irritants in inflammatory response. …”
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“…Viruses infecting vertebrate hosts must overcome the interferon (IFN)-mediated antiviral response to replicate and propagate to new hosts. …”
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