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  1. 1801
    “…While type I interferon (IFN) is best known for its key role against viral infection, accumulating preclinical and clinical data indicate that robust type I IFN production in the tumor microenvironment promotes cancer immunosurveillance and contributes to the efficacy of various antineoplastic agents, notably immunogenic cell death inducers. …”
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    Type I interferon signaling in malignant blasts contributes to treatment efficacy in AML patients
  2. 1802
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    Cold Storage Followed by Transplantation Induces Interferon-Gamma and STAT-1 in Kidney Grafts
  3. 1803
    “…Interferon lambdas (IFNLs) are innate immune cytokines that induce antiviral cellular responses by signaling through a heterodimer composed of IL10RB and the interferon lambda receptor 1 (IFNLR1). …”
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    Influence of Canonical and Non-Canonical IFNLR1 Isoform Expression on Interferon Lambda Signaling
  4. 1804
    “…Interferon-alpha inducible protein 6 (IFI6) is an interferon-stimulated gene (ISG), belonging to the FAM14 family of proteins and is localized in the mitochondrial membrane, where it plays a role in apoptosis. …”
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    Molecular analysis of chicken interferon-alpha inducible protein 6 gene and transcriptional regulation
  5. 1805
    por Qin, Albert
    Publicado 2023
    “…Interferon-beta (IFN-β), an extracellular cytokine that initiates signaling pathways for gene regulation, has been demonstrated to function as a tumor suppressor protein through lentiviral gene transduction. …”
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    An anti-cancer surveillance by the interplay between interferon-beta and retinoblastoma protein RB1
  6. 1806
    “…After viral infection, the immune system starts the production of interferons, which induce the expression of the 2'-5'-oligoadenylate synthetase (OAS) family of interferon stimulated genes and activate the endoribonuclease RNaseL that provides antiviral protection by viral RNA degradation. …”
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    Occludin Regulates HIV-1 Infection by Modulation of the Interferon Stimulated OAS Gene Family
  7. 1807
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    Repression of interferon regulatory factor-4 (IRF4) hyperactivation restricts murine lupus
  8. 1808
    “…In contrast, subjective symptoms that persisted after use of antibiotics were associated with increased levels of serum interferon-α (IFN-α), which were already observed at study entry, and remained increased at each subsequent timepoint. …”
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    Association of Persistent Symptoms after Lyme Neuroborreliosis and Increased Levels of Interferon-α in Blood
  9. 1809
    “…Type III interferons (IFN–λs) exhibit potent antiviral activity and immunomodulatory effects in specific cells. …”
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    Biological Activity of Optimized Codon Bovine Type III Interferon Expressed in Pichia pastoris
  10. 1810
    “…We previously demonstrated that interferon-β (IFN-β) protects against sepsis via sirtuin 1-(SIRT1)-mediated immunosuppression. …”
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    Interferon-β alleviates sepsis by SIRT1-mediated blockage of endothelial glycocalyx shedding
  11. 1811
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    Inflammation versus regulation: how interferon-gamma contributes to type 1 diabetes pathogenesis
  12. 1812
    “…We demonstrate that triplication of the interferon receptor (IFNR) gene cluster on chromosome 21 is necessary for multiple phenotypes in a mouse model of DS. …”
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    Triplication of the interferon receptor locus contributes to hallmarks of Down syndrome in a mouse model
  13. 1813
    “…Interferons were repeatedly used in the therapy of COVID-19 due to their antiviral effects. …”
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    Interferons in COVID-19: missed opportunities to prove efficacy in clinical phase III trials?
  14. 1814
    “…As for the treatment options, only limited antiviral agents have been approved hitherto, and clinicians mainly focus on currently available drugs including the conventional antiviral interferons (IFNs). In clinical practice, IFNs, when used either alone or in combination with ribavirin and/or lopinavir/ritonavir, have shown promising outcomes, to some extent, in SARS-CoV or MERS-CoV treatment. …”
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    Reconsideration of interferon treatment for viral diseases: Lessons from SARS, MERS, and COVID-19
  15. 1815
    “…Here, using a human-induced pluripotent stem cell (iPSC)-based model and the Dp(16)1Yey/+ (Dp16) mouse model of DS, we identified downregulation of canonical Wnt signaling downstream of increased dosage of interferon (IFN) receptors (IFNRs) genes on chromosome 21 as a causative factor of cardiogenic dysregulation in DS. …”
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    Interferon hyperactivity impairs cardiogenesis in Down syndrome via downregulation of canonical Wnt signaling
  16. 1816
    “…Moreover, by using RNA sequencing (RNA-seq), we also show a more pronounced expression of interferon-stimulated genes (ISGs) in BTV-infected cow cells than sheep cells. …”
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    The Timing and Magnitude of the Type I Interferon Response Are Correlated with Disease Tolerance in Arbovirus Infection
  17. 1817
    “…Interferons (IFNs) have demonstrated therapeutic potential in various skin cancers, specifically squamous cell carcinoma (SCC), basal cell carcinoma (BCC), and melanoma. …”
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    The Immunotherapeutic Role of Type I and III Interferons in Melanoma and Non-Melanoma Skin Cancers
  18. 1818
    “…To achieve the painless administration of interferon alpha 1b (rhIFNα-1b), a double-layered soluble polymer microneedle (MN) patch loaded with rhIFNα-1b was used to deliver rhIFNα-1b transdermally. …”
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    Soluble Polymer Microneedles Loaded with Interferon Alpha 1b for Treatment of Hyperplastic Scar
  19. 1819
    “…The organism is also known to cause a false positive reaction to interferon-γ release assay, the test to diagnose latent tuberculosis infection. …”
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    Mandibular Nodule Caused by Mycobacterium marinum with False Positive Interferon-γ Release Assay
  20. 1820
    “…Single-cell RNA sequencing combined with strand-specific total RNA-seq and ChIP-seq analysis revealed that ablation of Lsd1 led to the aberrant derepression of endogenous retroelements, which resulted in a viral mimicry state and activated the interferon pathway. Furthermore, the deletion of Lsd1 blocked the programmed sequential down-regulation of CD8 expression at the DP→CD4(+)CD8(lo) stage and induced an innate memory phenotype in both thymic and peripheral T cells. …”
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    Lsd1 safeguards T-cell development via suppressing endogenous retroelements and interferon responses
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