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1801por Holicek, Peter, Truxova, Iva, Rakova, Jana, Salek, Cyril, Hensler, Michal, Kovar, Marek, Reinis, Milan, Mikyskova, Romana, Pasulka, Josef, Vosahlikova, Sarka, Remesova, Hana, Valentova, Iva, Lysak, Daniel, Holubova, Monika, Kaspar, Petr, Prochazka, Jan, Kasikova, Lenka, Spisek, Radek, Galluzzi, Lorenzo, Fucikova, Jitka“…While type I interferon (IFN) is best known for its key role against viral infection, accumulating preclinical and clinical data indicate that robust type I IFN production in the tumor microenvironment promotes cancer immunosurveillance and contributes to the efficacy of various antineoplastic agents, notably immunogenic cell death inducers. …”
Publicado 2023
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1802
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1803“…Interferon lambdas (IFNLs) are innate immune cytokines that induce antiviral cellular responses by signaling through a heterodimer composed of IL10RB and the interferon lambda receptor 1 (IFNLR1). …”
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1804por Park, Jeong-Woong, Ndimukaga, Marc, So, Jaerung, Kim, Sujung, Truong, Anh Duc, Tran, Ha Thi Thanh, Dang, Hoang Vu, Song, Ki-Duk“…Interferon-alpha inducible protein 6 (IFI6) is an interferon-stimulated gene (ISG), belonging to the FAM14 family of proteins and is localized in the mitochondrial membrane, where it plays a role in apoptosis. …”
Publicado 2023
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1805por Qin, Albert“…Interferon-beta (IFN-β), an extracellular cytokine that initiates signaling pathways for gene regulation, has been demonstrated to function as a tumor suppressor protein through lentiviral gene transduction. …”
Publicado 2023
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1806por Torices, Silvia, Teglas, Timea, Naranjo, Oandy, Fattakhov, Nikolai, Frydlova, Kristyna, Cabrera, Rosalba, Osborne, Olivia M., Sun, Enze, Kluttz, Allan, Toborek, Michal“…After viral infection, the immune system starts the production of interferons, which induce the expression of the 2'-5'-oligoadenylate synthetase (OAS) family of interferon stimulated genes and activate the endoribonuclease RNaseL that provides antiviral protection by viral RNA degradation. …”
Publicado 2023
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1807por He, Shijun, Ding, Huihua, Chen, Li, Shen, Yiwei, Liu, Yuting, Zhu, Fenghua, Yang, Xiaoqian, Shen, Nan, Lin, Zemin, Zuo, JianpingEnlace del recurso
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1808por Hernández, Sergio A., Ogrinc, Katarina, Korva, Miša, Kastrin, Andrej, Bogovič, Petra, Rojko, Tereza, Kelley, Keith W., Weis, Janis J., Strle, Franc, Strle, Klemen“…In contrast, subjective symptoms that persisted after use of antibiotics were associated with increased levels of serum interferon-α (IFN-α), which were already observed at study entry, and remained increased at each subsequent timepoint. …”
Publicado 2023
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1809por An, Ran, Zhang, Runxiang, Guo, Yongli, Geng, Jinfeng, Si, Minglu, Wang, Shuangfeng, Gao, Mingchun, Wang, Junwei“…Type III interferons (IFN–λs) exhibit potent antiviral activity and immunomodulatory effects in specific cells. …”
Publicado 2023
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1810“…We previously demonstrated that interferon-β (IFN-β) protects against sepsis via sirtuin 1-(SIRT1)-mediated immunosuppression. …”
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1812por Waugh, Katherine A., Minter, Ross, Baxter, Jessica, Chi, Congwu, Galbraith, Matthew D., Tuttle, Kathryn D., Eduthan, Neetha P., Kinning, Kohl T., Andrysik, Zdenek, Araya, Paula, Dougherty, Hannah, Dunn, Lauren N., Ludwig, Michael, Schade, Kyndal A., Tracy, Dayna, Smith, Keith P., Granrath, Ross E., Busquet, Nicolas, Khanal, Santosh, Anderson, Ryan D., Cox, Liza L., Estrada, Belinda Enriquez, Rachubinski, Angela L., Lyford, Hannah R., Britton, Eleanor C., Fantauzzo, Katherine A., Orlicky, David J., Matsuda, Jennifer L., Song, Kunhua, Cox, Timothy C., Sullivan, Kelly D., Espinosa, Joaquin M.“…We demonstrate that triplication of the interferon receptor (IFNR) gene cluster on chromosome 21 is necessary for multiple phenotypes in a mouse model of DS. …”
Publicado 2023
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1813“…Interferons were repeatedly used in the therapy of COVID-19 due to their antiviral effects. …”
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1814“…As for the treatment options, only limited antiviral agents have been approved hitherto, and clinicians mainly focus on currently available drugs including the conventional antiviral interferons (IFNs). In clinical practice, IFNs, when used either alone or in combination with ribavirin and/or lopinavir/ritonavir, have shown promising outcomes, to some extent, in SARS-CoV or MERS-CoV treatment. …”
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1815por Chi, Congwu, Knight, Walter E., Riching, Andrew S., Zhang, Zhen, Tatavosian, Roubina, Zhuang, Yonghua, Moldovan, Radu, Rachubinski, Angela L., Gao, Dexiang, Xu, Hongyan, Espinosa, Joaquin M., Song, Kunhua“…Here, using a human-induced pluripotent stem cell (iPSC)-based model and the Dp(16)1Yey/+ (Dp16) mouse model of DS, we identified downregulation of canonical Wnt signaling downstream of increased dosage of interferon (IFN) receptors (IFNRs) genes on chromosome 21 as a causative factor of cardiogenic dysregulation in DS. …”
Publicado 2023
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1816por Hardy, Alexandra, Bakshi, Siddharth, Furnon, Wilhelm, MacLean, Oscar, Gu, Quan, Varjak, Margus, Varela, Mariana, Aziz, Muhamad Afiq, Shaw, Andrew E., Pinto, Rute Maria, Cameron Ruiz, Natalia, Mullan, Catrina, Taggart, Aislynn E., Da Silva Filipe, Ana, Randall, Richard E., Wilson, Sam J., Stewart, Meredith E., Palmarini, Massimo“…Moreover, by using RNA sequencing (RNA-seq), we also show a more pronounced expression of interferon-stimulated genes (ISGs) in BTV-infected cow cells than sheep cells. …”
Publicado 2023
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1817“…Interferons (IFNs) have demonstrated therapeutic potential in various skin cancers, specifically squamous cell carcinoma (SCC), basal cell carcinoma (BCC), and melanoma. …”
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1818“…To achieve the painless administration of interferon alpha 1b (rhIFNα-1b), a double-layered soluble polymer microneedle (MN) patch loaded with rhIFNα-1b was used to deliver rhIFNα-1b transdermally. …”
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1819“…The organism is also known to cause a false positive reaction to interferon-γ release assay, the test to diagnose latent tuberculosis infection. …”
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1820Lsd1 safeguards T-cell development via suppressing endogenous retroelements and interferon responsespor Xia, Miaoran, Wang, Bingbing, Sun, Wujianan, Ji, Dengyu, Zhou, Hang, Huang, Xuefeng, Yu, Minghang, Su, Ziyang, Chen, Ping, Qu, Kun, Wang, Xi“…Single-cell RNA sequencing combined with strand-specific total RNA-seq and ChIP-seq analysis revealed that ablation of Lsd1 led to the aberrant derepression of endogenous retroelements, which resulted in a viral mimicry state and activated the interferon pathway. Furthermore, the deletion of Lsd1 blocked the programmed sequential down-regulation of CD8 expression at the DP→CD4(+)CD8(lo) stage and induced an innate memory phenotype in both thymic and peripheral T cells. …”
Publicado 2023
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