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1901por Figlerowicz, Magdalena, Jackowiak, Paulina, Formanowicz, Piotr, Kędziora, Paweł, Alejska, Magdalena, Malinowska, Nelli, Błażewicz, Jacek, Figlerowicz, Marek“…Here, we present a bioinformatic analysis of HCV-1a populations isolated from 23 children with chronic hepatitis C (CHC) subjected to interferon–ribavirin therapy. The structures of the viral quasispecies were established based on a 132-amino-acid sequence derived from E1/E2 protein, including hypervariable region 1 (HVR1). …”
Publicado 2010
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1902por Murakami, Yoshiki, Tanaka, Masami, Toyoda, Hidenori, Hayashi, Katsuyuki, Kuroda, Masahiko, Tajima, Atsushi, Shimotohno, Kunitada“…The current standard treatment for chronic hepatitis (CH) C combines pegylated interferon (IFN) and ribavirin, and is less than ideal due to undesirable effects. …”
Publicado 2010
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1903
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1904“…Gamma interferon (gamma-IFN), a lymphokine produced by activated T lymphocytes, has a variety of effects on target cell. …”
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1905por Lee, Seung Won, Kim, Ki Chan, Oh, Dong Ho, Jung, Sung Soo, Yoo, Dae Hyun, Kim, Seong Yoon, Choe, Gheeyoung, Kim, Tae Hwan“…Polymyositis is a rare complication of interferon alpha treatment as a result of immune-modulating role of the drug itself. …”
Publicado 2002
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1906“…The production of type I interferons (IFNs) in response to viral infections is critical for antiviral immunity. …”
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1907por Petersen, Thor, Møller-Larsen, Anné, Thiel, Steffen, Hansen, Troels K, Ellermann-Eriksen, Svend, Brudek, Tomasz, Christensen, ToveEnlace del recurso
Publicado 2011
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1908por Seeds, Rosalind E., Mukhopadhyay, Subhankar, Jones, Ian M., Gordon, Siamon, Miller, Joanna L.“…This study tested the hypothesis that a set of predominantly myeloid restricted receptors (F4/80, CD36, Dectin-1, CD200 receptor and mannan binding lectins) and the broadly expressed CD200 played a role in a key function of plasmacytoid DC (pDC), virally induced type I interferon (IFN) production. The Dectin-1 ligands zymosan, glucan phosphate and the anti-Dectin-1 monoclonal antibody (mAb) 2A11 had no effect on influenza virus induced IFNα/β production by murine splenic pDC. …”
Publicado 2011
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1909“…Chronic hepatitis C (CHC) patients often stop pursuing interferon-alfa and ribavirin (IFN-alfa/RBV) treatment because of the high cost and associated adverse effects. …”
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1910por Modorati, Giulio, Matteo, Di Federico, Miserocchi, Elisabetta, Colucci, Annalisa, Bandello, Francesco“…METHODS: We reviewed the clinical records of two patients who were diagnosed with VKH-like disease during combined interferon-α (IFNα) and ribavirin treatment. RESULTS: Interruption of IFNα and ribavirin treatment in association with oral corticosteroids resulted in a favorable visual outcome in the case of diffuse retinal detachment (case 1). …”
Publicado 2011
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1911“…BACKGROUND: Neuropsychiatric adverse effects of interferon (IFN) alpha are well known. There is little clinically relevant research on animal models of depression with recombinant human IFN alpha 2b (rhIFN-α2b). …”
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1912“…We have investigated the ability of NSDV to antagonise the induction and actions of interferon. Both pathogenic and apathogenic isolates could actively inhibit the induction of type 1 interferon, and also blocked the signalling pathways of both type 1 and type 2 interferons. …”
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1913por Singal, Ashwani KumarEnlace del recurso
Publicado 2010
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1914“…Combination therapy with pegylated interferon (PEG-IFN) and Ribavirin is the treatment of choice for CHC. …”
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1915“…BACKGROUND: Interferon based therapy is used to eradicate the Hepatitis C Virus from the bodies of the infected individuals. …”
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1916por Bürgi, Milagros, Prieto, Claudio, Oggero, Marcos, Bollati-Fogolín, Mariela, Etcheverrigaray, Marina, Kratje, RicardoEnlace del recurso
Publicado 2011
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1917por Aubry, Camille, Corr, Sinéad C., Wienerroither, Sebastian, Goulard, Céline, Jones, Ruth, Jamieson, Amanda M., Decker, Thomas, O'Neill, Luke A. J., Dussurget, Olivier, Cossart, Pascale“…Synthesis of interferon-β (IFN-β) is an innate response to cytoplasmic infection with bacterial pathogens. …”
Publicado 2012
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1918por Fang, Terry C., Schaefer, Uwe, Mecklenbrauker, Ingrid, Stienen, Astrid, Dewell, Scott, Chen, Marie S., Rioja, Inmaculada, Parravicini, Valentino, Prinjha, Rab K., Chandwani, Rohit, MacDonald, Margaret R., Lee, Kevin, Rice, Charles M., Tarakhovsky, Alexander“…Effective antiviral immunity depends on the ability of infected cells or cells triggered with virus-derived nucleic acids to produce type I interferon (IFN), which activates transcription of numerous antiviral genes. …”
Publicado 2012
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1919“…As a result, viruses may persist in host and develop chronic infections. Type I interferons (IFN-α/β) are among the most potent antiviral cytokines triggered by viral infections. …”
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1920por Su, Yi, Tang, Lu-Ying, Chen, Li-Juan, He, Jian-Rong, Su, Feng-Xi, Lin, Ying, Chen, Wei-Qing, Xie, Xiao-Ming, Ren, Ze-Fang“…BACKGROUND: There is an inverse relationship between febrile infection and the risk of malignancies. Interferon gamma (IFN-γ) plays an important role in fever induction and its expression increases with incubation at fever-range temperatures. …”
Publicado 2012
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