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1921por Wu, Kang, Dong, Dandan, Fang, Hai, Levillain, Florence, Jin, Wen, Mei, Jian, Gicquel, Brigitte, Du, Yanzhi, Wang, Kankan, Gao, Qian, Neyrolles, Olivier, Zhang, Ji“…Analysis of the putative transcription factor binding sites in promoter regions of genes in this signature identified several key regulators, namely STATs, IRF-1, IRF-7, and Oct-1, commonly involved in interferon-related immune responses. The THP1r2Mtb-induced signature appeared to be highly relevant to the interferon-inducible signature recently reported in active pulmonary tuberculosis patients, as revealed by cross-signature and cross-module comparisons. …”
Publicado 2012
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1922por Fernández, Oscar, Agüera, Javier, Izquierdo, Guillermo, Millán-Pascual, Javier, Ramió i Torrentà, Lluis, Oliva, Pedro, Argente, Javier, Berdei, Yasmina, Soler, Jose Maria, Carmona, Olga, Errea, Jose Maria, Farrés, JordiEnlace del recurso
Publicado 2012
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1923por Tomassini, Barbara, Arcuri, Gaetano, Fortuni, Silvia, Sandi, Chiranjeevi, Ezzatizadeh, Vahid, Casali, Carlo, Condò, Ivano, Malisan, Florence, Al-Mahdawi, Sahar, Pook, Mark, Testi, Roberto“…Here, we show that frataxin levels can be upregulated by interferon gamma (IFNγ) in a variety of cell types, including primary cells derived from FRDA patients. …”
Publicado 2012
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1924por Prchal-Murphy, Michaela, Semper, Christian, Lassnig, Caroline, Wallner, Barbara, Gausterer, Christian, Teppner-Klymiuk, Ingeborg, Kobolak, Julianna, Müller, Simone, Kolbe, Thomas, Karaghiosoff, Marina, Dinnyés, Andras, Rülicke, Thomas, Leitner, Nicole R., Strobl, Birgit, Müller, Mathias“…We show that kinase-active TYK2 is required for full-fledged type I interferon- (IFN) induced activation of the transcription factors STAT1-4 and for the in vivo antiviral defence against viruses primarily controlled through type I IFN actions. …”
Publicado 2012
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1925por Rand, Ulfert, Rinas, Melanie, Schwerk, Johannes, Nöhren, Gesa, Linnes, Melanie, Kröger, Andrea, Flossdorf, Michael, Kály-Kullai, Kristóf, Hauser, Hansjörg, Höfer, Thomas, Köster, Mario“…The cellular recognition of viruses evokes the secretion of type-I interferons (IFNs) that induce an antiviral protective state. …”
Publicado 2012
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1926por Ottaviani, Diego, Lever, Elliott, Mao, Shihong, Christova, Rossitza, Ogunkolade, Babatunji W., Jones, Tania A., Szary, Jaroslaw, Aarum, Johan, Mumin, Muhammad A., Pieri, Christopher A., Krawetz, Stephen A., Sheer, Denise“…Activation of the major histocompatibility complex (MHC) by interferon-gamma (IFN−γ) is a fundamental step in the adaptive immune response to pathogens. …”
Publicado 2012
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1927por Wernike, Kerstin, Breithaupt, Angele, Keller, Markus, Hoffmann, Bernd, Beer, Martin, Eschbaumer, Michael“…The goal of this study was to investigate whether type I interferon receptor knock-out (IFNAR(−/−)) mice are a suitable small animal model for SBV. …”
Publicado 2012
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1928por Ramírez-Vélez, Gabriela, Medina, Francisco, Ramírez-Montaño, Luis, Zarazúa-Lozada, Abraham, Hernández, Ramiro, Llorente, Luis, Moreno, José“…BACKGROUND: Overexpression of type I interferon (IFN-I)-induced genes is a common feature of systemic lupus erythematosus (SLE) and its experimental models, but the participation of endogenous overproduction of IFN-I on it is not clear. …”
Publicado 2012
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1929por Schoggins, John W., Wilson, Sam J., Panis, Maryline, Murphy, Mary Y., Jones, Christopher T., Bieniasz, Paul, Rice, Charles M.“…The type I interferon (IFN) response protects cells from invading viral pathogens. …”
Publicado 2011
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1930por Gibbert, Kathrin, Joedicke, Jara J., Meryk, Andreas, Trilling, Mirko, Francois, Sandra, Duppach, Janine, Kraft, Anke, Lang, Karl S., Dittmer, Ulf“…Here, we show that subtype 11 of the type I interferon (IFN) family greatly potentiates the antiviral activity of NK cells during retroviral infection. …”
Publicado 2012
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1931por Zhang, Ling, Yin, Sen, Tan, Wanlong, Xiao, Dong, Weng, Yunceng, Wang, Wenjing, Li, Tingting, Shi, Junwen, Shuai, Lifang, Li, Hongwei, Zhou, Jianhua, Allain, Jean-Pierre, Li, Chengyao“…Recombinant interferon-γ (IFNγ) production in cultured lentivirus (LV) was explored for inhibition of target virus in cells co-infected with adenovirus type 5 (Ad5). …”
Publicado 2012
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1932por Zwerling, Alice, Cojocariu, Mihaela, McIntosh, Fiona, Pietrangelo, Filomena, Behr, Marcel A., Schwartzman, Kevin, Benedetti, Andrea, Dendukuri, Nandini, Menzies, Dick, Pai, Madhukar“…BACKGROUND: While many North American healthcare institutions are switching from Tuberculin Skin Test (TST) to Interferon-gamma release assays (IGRAs), there is relatively limited data on association between occupational tuberculosis (TB) risk factors and test positivity and/or patterns of test discordance. …”
Publicado 2012
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1933“…The combination therapy of interferon beta-1b and tacrolimus over the 10-month period of the study was shown to be safe and relatively well tolerated. …”
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1934“…Very recently, three landmark genome-wide association studies identified single nucleotide polymorphisms near the interleukin 28B (IL28B) region which were more frequent in responders to treatment. IL28B encodes interferon (IFN)λ3, a type III IFN involved in host antiviral immunity. …”
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1935“…BACKGROUND: Interferon-β (IFN-β) is an effective drug in multiple sclerosis (MS) but it may cause acute exacerbation of MS following the initiation of treatment. …”
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1936por Banik, Debarati, Khan, A. Nazmul H., Walseng, Even, Segal, Brahm H., Abrams, Scott I.“…We had previously shown that interferon regulatory factor (IRF)-8, originally discovered as a leukemia suppressor gene by regulating apoptosis, also regulates Fas-mediated killing in non-hematologic tumor models. …”
Publicado 2012
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1937por Biacchesi, Stéphane, Mérour, Emilie, Lamoureux, Annie, Bernard, Julie, Brémont, Michel“…More recently, an endoplasmic reticulum (ER) adaptor: the stimulator of interferon genes (STING) protein, also called MITA, ERIS and MPYS, has been shown to play a pivotal role in response to both non-self-cytosolic RNA and dsDNA. …”
Publicado 2012
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1938por Kamm, Christian Philipp, El-Koussy, Marwan, Humpert, Sebastian, Findling, Oliver, von Bredow, Ferdinand, Burren, Yuliya, Schwegler, Guido, Schött, Dagmar, Donati, Filippo, Müller, Martin, Goebels, Norbert, Müller, Felix, Slotboom, Johannes, Tettenborn, Barbara, Kappos, Ludwig, Naegelin, Yvonne, Mattle, Heinrich Paul“…Seventy-seven patients with relapsing-remitting MS started interferon beta-1b every other day. After 3 months, they were randomized 1:1 to receive atorvastatin 40 mg/day or not in addition to interferon beta-1b until month 15. …”
Publicado 2012
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1939por Schlatterer, Sarah D, Suh, Hyeon-sook, Conejero-Goldberg, Concepcion, Chen, Shufen, Acker, Christopher M, Lee, Sunhee C, Davies, Peter“…RESULTS: Two of the top pathways upregulated in AblPP/tTA mice with c-Abl expression for 2 weeks were cell cycle and interferon signaling. However, only the expression of interferon signaling pathway genes remained elevated at 4 weeks of c-Abl induction. …”
Publicado 2012
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1940por Martínez-Gil, Luis, Ayllon, Juan, Ortigoza, Mila Brum, García-Sastre, Adolfo, Shaw, Megan L., Palese, Peter“…The continuous emergence of virus that are resistant to current anti-viral drugs, combined with the introduction of new viral pathogens for which no therapeutics are available, creates an urgent need for the development of novel broad spectrum antivirals. Type I interferon (IFN) can, by modulating the cellular expression profile, stimulate a non-specific antiviral state. …”
Publicado 2012
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