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  1. 3121
    “…Background: The Pilots for Healthy and Active Ageing (PHArA-ON) project aimsto ensure reality smart and active living for Europe’s ageing population by creating a set of integrated and highly customizable interoperable open platforms with advanced services, devices, and technologies and tools. …”
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    Pilots for Healthy and Active Ageing (PHArA-ON) Project: Definition of New Technological Solutions for Older People in Italian Pilot Sites Based on Elicited User Needs
  2. 3122
    “…Use cases exemplify how the members of the Worldwide Protein Data Bank have used PDBx/mmCIF as the foundation for its pipeline for delivering Findable, Accessible, Interoperable, and Reusable (FAIR) data to many millions of users worldwide.…”
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    PDBx/mmCIF Ecosystem: Foundational Semantic Tools for Structural Biology
  3. 3123
    “…Database queries yield structured information in a variety of interoperable formats. By visualizing data on maps, users can explore this vast dataset and develop their own theories. …”
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    The ROCEEH Out of Africa Database (ROAD): A large-scale research database serves as an indispensable tool for human evolutionary studies
  4. 3124
    “…Others included a shortage of skilled personnel, a lack of interoperable e-health platforms and care integration policy implementation gaps. …”
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    Perceived health system facilitators and barriers to integrated management of hypertension and type 2 diabetes in Kenya: a qualitative study
  5. 3125
    “…Still, the potential of interoperable knowledge sources for biomedicine, at the scale of the World Wide Web, merits continued work.…”
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    Advancing translational research with the Semantic Web
  6. 3126
    “…Precision errors for the morphologic parameters were smaller than 3% and 6% for intra- and interoperator analysis, respectively. Accuracy errors for vessel thickness were around 20% for vessels larger than twice the resolution of the scanner. …”
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    Characterization and quantification of angiogenesis in rheumatoid arthritis in a mouse model using μCT
  7. 3127
    “…Interclass correlation coefficients were used to assess interoperator agreement for ESS and NCI-CTCAE v4.0 scoring. …”
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    Skin toxicity evaluation in patients treated with cetuximab for metastatic colorectal cancer: a new tool for more accurate comprehension of quality of life impacts
  8. 3128
    “…It can be extended as required in the light of future scientific advances, but already provides the starting point for the creation of FAIR (Findable, Accessible, Interoperable and Reusable) knowledge bases of data on the congenital myasthenic syndromes.…”
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    A nomenclature and classification for the congenital myasthenic syndromes: preparing for FAIR data in the genomic era
  9. 3129
    “…The custom-built web application and the trusted environment of the Flemish hospital network created an interoperable strategy to get to work with SMR findings. …”
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    Standardised mortality ratios as a user-friendly performance metric and trigger for quality improvement in a Flemish hospital network: multicentre retrospective study
  10. 3130
    “…CAGEfightR is designed to be interoperable with other Bioconductor packages, thereby unlocking hundreds of mature transcriptomic analysis tools for 5′-end data. …”
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    CAGEfightR: analysis of 5′-end data using R/Bioconductor
  11. 3131
    “…DICs transform heterogeneous primary clinical data into an interoperable format, and the HELP-CDSS displays information according to current best evidence in bacteraemia treatment. …”
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    Hospital-wide ELectronic medical record evaluated computerised decision support system to improve outcomes of Patients with staphylococcal bloodstream infection (HELP): study protocol for a multicentre stepped-wedge cluster randomised trial
  12. 3132
    “…An excellent intra-operator ICC of 0.90 (p < 0.01) was found for the ImageJ quantification method while a good interoperator ICC of 0.69 (p < 0.01) was measured. No significant difference was observed between the variation of the ImageJ and that of the manual counting method. …”
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    Development of a computer-based quantification method for immunohistochemically-stained tissues and its application to study mast cells in equine wound healing (proof of concept)
  13. 3133
    “…The T cell Receptor/Immunoglobulin Profiler (TRIP) tool offers the opportunity for an in-depth analysis based on the processing of the output files of the IMGT/HighV-Quest tool, a standard in NGS immunoprofiling, through a number of interoperable modules. These provide detailed information about antigen receptor gene rearrangements, including variable (V), diversity (D) and joining (J) gene usage, CDR3 amino acid and nucleotide composition and clonality of both T cell receptors (TR) and B cell receptor immunoglobulins (BcR IG), and characteristics of the somatic hypermutation within the BcR IG genes. …”
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    TRIP - T cell receptor/immunoglobulin profiler
  14. 3134
    “…Considering that these systems provide significant benefit to a vast number of stakeholders, can be applied to the functional diversity of application domains and have high economic and social impacts, it is essential to create reusable and interoperable platforms and standards that are able to deal with the heterogeneity of applications and domains. …”
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    Reference architectures for ambient assisted living: a scoping review protocol
  15. 3135
    “…CONCLUSION: The development of robust, interoperable, and secure electronic registries that generate value for research and patients presents itself as a solution and a challenge. …”
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    National registry for amyotrophic lateral sclerosis: a systematic review for structuring population registries of motor neuron diseases
  16. 3136
    “…This planning process can delay treatment while also introducing interoperator variability, resulting in downstream radiation dose differences. …”
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    Clinically Applicable Segmentation of Head and Neck Anatomy for Radiotherapy: Deep Learning Algorithm Development and Validation Study
  17. 3137
    “…The next steps are to determine if DDInteract can improve shared decision-making quality and to implement it across health systems using interoperable technology.…”
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    A Shared Decision-making Tool for Drug Interactions Between Warfarin and Nonsteroidal Anti-inflammatory Drugs: Design and Usability Study
  18. 3138
    “…These heterogeneous datasets will be described, harmonised and integrated into a multi-user data repository operated through Opal-DataSHIELD, an interoperable open-source server application. Federated data analyses, without sharing or disclosing any individual-level data, will be performed with the objective to reveal patients’ baseline characteristics, biomarkers, determinants of COVID-19 prognosis, safety and effectiveness of treatments, and potential strategies against COVID-19, as well as epidemiological patterns. …”
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    Unravelling data for rapid evidence-based response to COVID-19: a summary of the unCoVer protocol
  19. 3139
    “…Sharing dark data by making it Findable, Accessible, Interoperable, and Reusable (FAIR) may reduce the burden of irreproducible science by increasing transparency and support data-driven discoveries beyond the lifecycle of the original study. …”
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    Excavating FAIR Data: the Case of the Multicenter Animal Spinal Cord Injury Study (MASCIS), Blood Pressure, and Neuro-Recovery
  20. 3140
    “…The literature also indicated a need for interoperable information systems and revealed the use of promising new technologies for data reporting and laboratory testing. …”
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    Comprehensive Vaccine-Preventable Disease Surveillance in the Western Pacific Region: A Literature Review on Integration of Surveillance Functions, 2000–2021
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