A novel biparatopic hybrid antibody-ACE2 fusion that blocks SARS-CoV-2 infection: implications for therapy

por Miao, Xiaoniu, Luo, Yi, Huang, Xi, Lee, Suki M. Y., Yuan, Zhijun, Tang, Yongzhou, Chen, Liandi, Wang, Chao, Wu, Fan, Xu, Yifeng, Jiang, Wenchao, Gao, Wei, Song, Xuedong, Yan, Yao, Pang, Tuling, Chen, Cheng, Zou, Yuefeng, Fu, Weihui, Wan, Liping, Gilbert-Jaramillo, Javier, Knight, Michael, Tan, Tiong Kit, Rijal, Pramila, Townsend, Alain, Sun, Joanne, Liu, Xiaolin, James, William, Tsun, Andy, Xu, Yingda
Publicado 2020

Ambulatory management of primary spontaneous pneumothorax: an open-label, randomised controlled trial

por Hallifax, Rob J, McKeown, Edward, Sivakumar, Parthipan, Fairbairn, Ian, Peter, Christy, Leitch, Andrew, Knight, Matthew, Stanton, Andrew, Ijaz, Asim, Marciniak, Stefan, Cameron, James, Bhatta, Amrithraj, Blyth, Kevin G, Reddy, Raja, Harris, Marie-Clare, Maddekar, Nadeem, Walker, Steven, West, Alex, Laskawiec-Szkonter, Magda, Corcoran, John P, Gerry, Stephen, Roberts, Corran, Harvey, John E, Maskell, Nick, Miller, Robert F, Rahman, Najib M
Publicado 2020

Optimising Exome Prenatal Sequencing Services (EXPRESS): a study protocol to evaluate rapid prenatal exome sequencing in the NHS Genomic Medicine Service

por Hill, Melissa, Ellard, Sian, Fisher, Jane, Fulop, Naomi, Knight, Marian, Kroese, Mark, Ledger, Jean, Leeson-Beevers, Kerry, McEwan, Alec, McMullan, Dominic, Mellis, Rhiannon, Morris, Stephen, Parker, Michael, Tapon, Dagmar, Baple, Emma, Blackburn, Laura, Choudry, Asya, Lafarge, Caroline, McInnes-Dean, Hannah, Peter, Michelle, Ramakrishnan, Rema, Roberts, Lauren, Searle, Beverly, Smith, Emma, Walton, Holly, Wynn, Sarah L., Han Wu, Wing, Chitty, Lyn S.
Publicado 2022

Maternal and perinatal Health Research Collaboration, India (MaatHRI): methodology for establishing a hospital-based research platform in a low and middle income country setting

por Nair, Manisha, Bezbaruah, Babul, Bora, Amrit Krishna, Bora, Krishnaram, Chhabra, Shakuntala, Choudhury, Saswati S., Choudhury, Arup, Deka, Dipika, Deka, Gitanjali, Ismavel, Vijay Anand, Kakoty, Swapna D., Koshy, Roshine M., Kumar, Pramod, Mahanta, Pranabika, Medhi, Robin, Nath, Pranoy, Rani, Anjali, Roy, Indrani, Sarma, Usha, V, Carolin Solomi, Talukdar, Ratna Kanta, Zahir, Farzana, Hill, Michael, Kansal, Nimmi, Nakra, Reena, Baigent, Colin, Knight, Marian, Kurinczuk, Jenny J.
Publicado 2021

Time series analysis and mechanistic modelling of heterogeneity and sero-reversion in antibody responses to mild SARS‑CoV-2 infection

por Manisty, Charlotte, Treibel, Thomas Alexander, Jensen, Melanie, Semper, Amanda, Joy, George, Gupta, Rishi K, Cutino-Moguel, Teresa, Andiapen, Mervyn, Jones, Jessica, Taylor, Stephen, Otter, Ashley, Pade, Corrina, Gibbons, Joseph, Lee, Jason, Bacon, Joanna, Thomas, Steve, Moon, Chris, Jones, Meleri, Williams, Dylan, Lambourne, Jonathan, Fontana, Marianna, Altmann, Daniel M, Boyton, Rosemary, Maini, Mala, McKnight, Aine, Chain, Benjamin, Noursadeghi, Mahdad, Moon, James C
Publicado 2021

Gastrointestinal Surgery for Inflammatory Bowel Disease Persistently Lowers Microbiome and Metabolome Diversity

por Fang, Xin, Vázquez-Baeza, Yoshiki, Elijah, Emmanuel, Vargas, Fernando, Ackermann, Gail, Humphrey, Gregory, Lau, Rebecca, Weldon, Kelly C, Sanders, Jon G, Panitchpakdi, Morgan, Carpenter, Carolina, Jarmusch, Alan K, Neill, Jennifer, Miralles, Ara, Dulai, Parambir, Singh, Siddharth, Tsai, Matthew, Swafford, Austin D, Smarr, Larry, Boyle, David L, Palsson, Bernhard O, Chang, John T, Dorrestein, Pieter C, Sandborn, William J, Knight, Rob, Boland, Brigid S
Publicado 2020

Cell-targeted PD-1 agonists that mimic PD-L1 are potent T cell inhibitors

por Curnock, Adam P., Bossi, Giovanna, Kumaran, Jyothi, Bawden, Lindsay J., Figueiredo, Rita, Tawar, Rajeevkumar, Wiseman, Katherine, Henderson, Emma, Hoong, Sec Julie, Gonzalez, Veronica, Ghadbane, Hemza, Knight, David E.O., O’Dwyer, Ronan, Overton, David X., Lucato, Christina M., Smith, Nicola M.G., Reis, Carlos R., Page, Keith, Whaley, Lorraine M., McCully, Michelle L., Hearty, Stephen, Mahon, Tara M., Weber, Peter
Publicado 2021

Differences in health outcomes for high‐need high‐cost patients across high‐income countries

por Papanicolas, Irene, Riley, Kristen, Abiona, Olukorede, Arvin, Mina, Atsma, Femke, Bernal‐Delgado, Enrique, Bowden, Nicholas, Blankart, Carl Rudolf, Deeny, Sarah, Estupiñán‐Romero, Francisco, Gauld, Robin, Haywood, Philip, Janlov, Nils, Knight, Hannah, Lorenzoni, Luca, Marino, Alberto, Or, Zeynep, Penneau, Anne, Schoenfeld, Andrew J., Shatrov, Kosta, Stafford, Mai, van de Galien, Onno, van Gool, Kees, Wodchis, Walter, Jha, Ashish K., Figueroa, Jose F.
Publicado 2021

Differences in health care spending and utilization among older frail adults in high‐income countries: ICCONIC hip fracture persona

por Papanicolas, Irene, Figueroa, Jose F., Schoenfeld, Andrew J., Riley, Kristen, Abiona, Olukorede, Arvin, Mina, Atsma, Femke, Bernal‐Delgado, Enrique, Bowden, Nicholas, Blankart, Carl Rudolf, Deeny, Sarah, Estupiñán‐Romero, Francisco, Gauld, Robin, Haywood, Philip, Janlov, Nils, Knight, Hannah, Lorenzoni, Luca, Marino, Alberto, Or, Zeynep, Penneau, Anne, Shatrov, Kosta, Stafford, Mai, van de Galien, Onno, van Gool, Kees, Wodchis, Walter, Jha, Ashish K.
Publicado 2021

Multiple site place-of-care manufactured anti-CD19 CAR-T cells induce high remission rates in B-cell malignancy patients

por Maschan, Michael, Caimi, Paolo F., Reese-Koc, Jane, Sanchez, Gabriela Pacheco, Sharma, Ashish A., Molostova, Olga, Shelikhova, Larisa, Pershin, Dmitriy, Stepanov, Alexey, Muzalevskii, Yakov, Suzart, Vinicius G., Otegbeye, Folashade, Wald, David, Xiong, Ying, Wu, Darong, Knight, Adam, Oparaocha, Ibe, Ferencz, Beatrix, Roy, Andre, Worden, Andrew, Kruger, Winfried, Kadan, Michael, Schneider, Dina, Orentas, Rimas, Sekaly, Rafick-Pierre, de Lima, Marcos, Dropulić, Boro
Publicado 2021

Activation of a cGAS-STING-mediated immune response predicts response to neoadjuvant chemotherapy in early breast cancer

por Parkes, Eileen E., Savage, Kienan I., Lioe, Tong, Boyd, Clinton, Halliday, Sophia, Walker, Steven M., Lowry, Keith, Knight, Laura, Buckley, Niamh E., Grogan, Andrena, Logan, Gemma E., Clayton, Alison, Hurwitz, Jane, Kirk, Stephen J., Xu, Jiamei, Sidi, Fatima Abdullahi, Humphries, Matthew P., Bingham, Victoria, James, Jaqueline A., James, Colin R., Paul Harkin, D., Kennedy, Richard D., McIntosh, Stuart A.
Publicado 2021

Phylogeny-Aware Analysis of Metagenome Community Ecology Based on Matched Reference Genomes while Bypassing Taxonomy

por Zhu, Qiyun, Huang, Shi, Gonzalez, Antonio, McGrath, Imran, McDonald, Daniel, Haiminen, Niina, Armstrong, George, Vázquez-Baeza, Yoshiki, Yu, Julian, Kuczynski, Justin, Sepich-Poore, Gregory D., Swafford, Austin D., Das, Promi, Shaffer, Justin P., Lejzerowicz, Franck, Belda-Ferre, Pedro, Havulinna, Aki S., Méric, Guillaume, Niiranen, Teemu, Lahti, Leo, Salomaa, Veikko, Kim, Ho-Cheol, Jain, Mohit, Inouye, Michael, Gilbert, Jack A., Knight, Rob
Publicado 2022

Pregnancy and Spontaneous Coronary Artery Dissection: Lessons From Survivors and Nonsurvivors

por Chan, Nathan, Premawardhana, Diluka, Al-Hussaini, Abtehale, Wood, Alice, Bountziouka, Vasiliki, Kotecha, Deevia, Swahn, Eva, Palmefors, Henning, Pagonis, Christos, Lawesson, Sofia Sederholm, Kądziela, Jacek, Garcia-Guimarães, Marcos, Alfonso, Fernando, Escaned, Javier, Macaya, Fernando, Santás, Melisa, Cerrato, Enrico, Maas, Angela H.E.M., Hlinomaz, Ota, Bogale, Nigussie, Cortese, Bernardo, Cheng, Mavis, Bolger, Aidan, Hussain, Shazia T., Samani, Nilesh J., Knight, Marian, Cauldwell, Matthew, Adlam, David
Publicado 2022

Plasma proteomic signature predicts who will get persistent symptoms following SARS-CoV-2 infection

por Captur, Gabriella, Moon, James C., Topriceanu, Constantin-Cristian, Joy, George, Swadling, Leo, Hallqvist, Jenny, Doykov, Ivan, Patel, Nina, Spiewak, Justyna, Baldwin, Tomas, Hamblin, Matt, Menacho, Katia, Fontana, Marianna, Treibel, Thomas A., Manisty, Charlotte, O'Brien, Ben, Gibbons, Joseph M., Pade, Corrina, Brooks, Tim, Altmann, Daniel M., Boyton, Rosemary J., McKnight, Áine, Maini, Mala K., Noursadeghi, Mahdad, Mills, Kevin, Heywood, Wendy E.
Publicado 2022

Effectiveness of a behavioural intervention delivered by text messages (safetxt) on sexually transmitted reinfections in people aged 16-24 years: randomised controlled trial

por Free, Caroline, Palmer, Melissa J, McCarthy, Ona L, Jerome, Lauren, Berendes, Sima, Knight, Megan, Carpenter, James R, Morris, Tim P, Jamal, Zahra, Dhaliwal, Farandeep, French, Rebecca S, Hickson, Ford Colin Ian, Gubijev, Anasztazia, Wellings, Kaye, Baraitser, Paula, Roberts, Ian, Bailey, Julia V, Clayton, Tim, Devries, Karen, Edwards, Phil, Hart, Graham, Michie, Susan, Macgregor, Louis, Turner, Katy M E, Potter, Kimberley
Publicado 2022

A blood DNA methylation biomarker for predicting short-term risk of cardiovascular events

por Cappozzo, Andrea, McCrory, Cathal, Robinson, Oliver, Freni Sterrantino, Anna, Sacerdote, Carlotta, Krogh, Vittorio, Panico, Salvatore, Tumino, Rosario, Iacoviello, Licia, Ricceri, Fulvio, Sieri, Sabina, Chiodini, Paolo, McKay, Gareth J., McKnight, Amy Jayne, Kee, Frank, Young, Ian S., McGuinness, Bernadette, Crimmins, Eileen M., Arpawong, Thalida Em, Kenny, Rose Anne, O’Halloran, Aisling, Polidoro, Silvia, Solinas, Giuliana, Vineis, Paolo, Ieva, Francesca, Fiorito, Giovanni
Publicado 2022

Genetic Risk of Cardiovascular Disease Is Associated with Macular Ganglion Cell–Inner Plexiform Layer Thinning in an Early Glaucoma Cohort

por Marshall, Henry, Mullany, Sean, Han, Xikun, Berry, Ella C., Hassall, Mark M., Qassim, Ayub, Nguyen, Thi, Hollitt, Georgina L., Knight, Lachlan S.W., Ridge, Bronwyn, Schmidt, Joshua, Crowley, Caroline, Schulz, Angela, Mills, Richard A., Agar, Ashish, Galanopoulos, Anna, Landers, John, Healey, Paul R., Graham, Stuart L., Hewitt, Alex W., Casson, Robert J., MacGregor, Stuart, Siggs, Owen M., Craig, Jamie E.
Publicado 2021

Pan-cancer analyses reveal cancer-type-specific fungal ecologies and bacteriome interactions

por Narunsky-Haziza, Lian, Sepich-Poore, Gregory D., Livyatan, Ilana, Asraf, Omer, Martino, Cameron, Nejman, Deborah, Gavert, Nancy, Stajich, Jason E., Amit, Guy, González, Antonio, Wandro, Stephen, Perry, Gili, Ariel, Ruthie, Meltser, Arnon, Shaffer, Justin P., Zhu, Qiyun, Balint-Lahat, Nora, Barshack, Iris, Dadiani, Maya, Gal-Yam, Einav N., Patel, Sandip Pravin, Bashan, Amir, Swafford, Austin D., Pilpel, Yitzhak, Knight, Rob, Straussman, Ravid
Publicado 2022

Impact of Earlier Diagnosis in Cardiac ATTR Amyloidosis Over the Course of 20 Years

por Ioannou, Adam, Patel, Rishi K., Razvi, Yousuf, Porcari, Aldostefano, Sinagra, Gianfranco, Venneri, Lucia, Bandera, Francesco, Masi, Ambra, Williams, Georgina E., O’Beara, Sophie, Ganesananthan, Sharmananthan, Massa, Paolo, Knight, Daniel, Martinez-Naharro, Ana, Kotecha, Tushar, Chacko, Liza, Brown, James, Rauf, Muhammad U., Manisty, Charlotte, Moon, James, Lachmann, Helen, Wechelakar, Ashutosh, Petrie, Aviva, Whelan, Carol, Hawkins, Philip N., Gillmore, Julian D., Fontana, Marianna
Publicado 2022

Cardiovascular magnetic resonance in light-chain amyloidosis to guide treatment

por Martinez-Naharro, Ana, Patel, Rishi, Kotecha, Tushar, Karia, Nina, Ioannou, Adam, Petrie, Aviva, Chacko, Liza A, Razvi, Yousuf, Ravichandran, Sriram, Brown, James, Law, Steven, Quarta, Cristina, Mahmood, Shameem, Wisniowski, Brendan, Pica, Silvia, Sachchithanantham, Sajitha, Lachmann, Helen J, Moon, James C, Knight, Daniel S, Whelan, Carol, Venneri, Lucia, Xue, Hui, Kellman, Peter, Gillmore, Julian D, Hawkins, Philip N, Wechalekar, Ashutosh D, Fontana, Marianna
Publicado 2022