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341por Elhadad, Mohamed A., Wilson, Rory, Zaghlool, Shaza B., Huth, Cornelia, Gieger, Christian, Grallert, Harald, Graumann, Johannes, Rathmann, Wolfgang, Koenig, Wolfgang, Sinner, Moritz F., Hveem, Kristian, Suhre, Karsten, Thorand, Barbara, Jonasson, Christian, Waldenberger, Melanie, Peters, Annette“…METHODS: Using a highly multiplexed aptamer-based affinity proteomics platform, we examined associations between plasma proteins and prevalent and incident MetS in the KORA cohort (n = 998) and replicated our results for prevalent MetS in the HUNT3 study (n = 923). …”
Publicado 2021
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342por Vogel, Carla IG, Scherag, André, Brönner, Günter, Nguyen, Thuy T, Wang, Hai-Jun, Grallert, Harald, Bornhorst, Alexa, Rosskopf, Dieter, Völzke, Henry, Reinehr, Thomas, Rief, Winfried, Illig, Thomas, Wichmann, H-Erich, Schäfer, Helmut, Hebebrand, Johannes, Hinney, Anke“…A similar trend was found in KORA where the rs2302382 A-allele led to an increase of 0.12 BMI units (p = 0.136). …”
Publicado 2009
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343por Knoll, Nadja, Jarick, Ivonne, Volckmar, Anna-Lena, Klingenspor, Martin, Illig, Thomas, Grallert, Harald, Gieger, Christian, Wichmann, Heinz-Erich, Peters, Annette, Hebebrand, Johannes, Scherag, André, Hinney, Anke“…For independent confirmation, we analyzed 705 obesity GWAS trios (extremely obese child and both biological parents) and a population-based GWAS sample (KORA F4, n = 1,743). A meta-analysis was performed on all three samples. …”
Publicado 2013
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344por Burghardt, Juliane, Tibubos, Ana Nanette, Otten, Danielle, Brähler, Elmar, Binder, Harald, Grabe, Hans, Kruse, Johannes, Ladwig, Karl Heinz, Schomerus, Georg, Wild, Philipp S, Beutel, Manfred E“…METHODS AND ANALYSIS: We plan to perform secondary analyses on three major, ongoing, population-based, longitudinal cohorts (Gutenberg Health-Study (GHS), Study of Health in Pomerania (SHIP), Cooperative Health Research in the Augsburg Region (KORA)) with data on mental and somatic symptoms, medical assessments and diagnoses in north-east, middle and southern Germany (n>40 000). …”
Publicado 2020
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345por Org, Elin, Eyheramendy, Susana, Juhanson, Peeter, Gieger, Christian, Lichtner, Peter, Klopp, Norman, Veldre, Gudrun, Döring, Angela, Viigimaa, Margus, Sõber, Siim, Tomberg, Kärt, Eckstein, Gertrud, Kelgo, Piret, Rebane, Tiina, Shaw-Hawkins, Sue, Howard, Philip, Onipinla, Abiodun, Dobson, Richard J., Newhouse, Stephen J., Brown, Morris, Dominiczak, Anna, Connell, John, Samani, Nilesh, Farrall, Martin, Caulfield, Mark J., Munroe, Patricia B., Illig, Thomas, Wichmann, H.-Erich, Meitinger, Thomas, Laan, Maris“…We conducted GWAS for three BP traits [systolic and diastolic blood pressure (SBP and DBP); hypertension (HYP)] in the Kooperative Gesundheitsforschung in der Region Augsburg (KORA) S3 cohort (n = 1644) recruited from general population in Southern Germany. …”
Publicado 2009
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346por Schulz, Holger, Flexeder, Claudia, Behr, Jürgen, Heier, Margit, Holle, Rolf, Huber, Rudolf M., Jörres, Rudolf A., Nowak, Dennis, Peters, Annette, Wichmann, H.-Erich, Heinrich, Joachim, Karrasch, Stefan“…Regarding our equations the indices were beyond the limits of normal in 8.1% to 18.6% of the entire KORA cohort (n = 1990), and in 0.7% to 9.4% with the currently applied equations. …”
Publicado 2013
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347por Schramm, Katharina, Marzi, Carola, Schurmann, Claudia, Carstensen, Maren, Reinmaa, Eva, Biffar, Reiner, Eckstein, Gertrud, Gieger, Christian, Grabe, Hans-Jörgen, Homuth, Georg, Kastenmüller, Gabriele, Mägi, Reedik, Metspalu, Andres, Mihailov, Evelin, Peters, Annette, Petersmann, Astrid, Roden, Michael, Strauch, Konstantin, Suhre, Karsten, Teumer, Alexander, Völker, Uwe, Völzke, Henry, Wang-Sattler, Rui, Waldenberger, Melanie, Meitinger, Thomas, Illig, Thomas, Herder, Christian, Grallert, Harald, Prokisch, Holger“…MATERIALS AND METHODS: We performed whole-genome eQTL analyses in 890 participants of the KORA F4 study and in two independent replication samples (SHIP-TREND, N = 976 and EGCUT, N = 842) using linear regression models and Bonferroni correction. …”
Publicado 2014
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348por Tamayo, Teresa, Claessen, Heiner, Rückert, Ina-Maria, Maier, Werner, Schunk, Michaela, Meisinger, Christine, Mielck, Andreas, Holle, Rolf, Thorand, Barbara, Narres, Maria, Moebus, Susanne, Mahabadi, Amir-Abbas, Pundt, Noreen, Krone, Bastian, Slomiany, Uta, Erbel, Raimund, Jöckel, Karl-Heinz, Rathmann, Wolfgang, Icks, Andrea“…RESULTS: The examined sample comprised 662 participants with self-reported type 2 diabetes (KORA F4: 83 women, 111 men; HNR: 183 women, 285 men). …”
Publicado 2014
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349por Brunner, Stefan, Herbel, Rebecca, Drobesch, Cathrine, Peters, Annette, Massberg, Steffen, Kääb, Stefan, Sinner, Moritz F.“…Similarly, we analysed 4131 participants of the community-based KORA S4 Study (Co-operative Health Research in the Region of Augsburg) and associated cardiac arrhythmias with chronic alcohol consumption. …”
Publicado 2017
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350por de F.C. Lichtenfels, Ana Julia, van der Plaat, Diana A., de Jong, Kim, van Diemen, Cleo C., Postma, Dirkje S., Nedeljkovic, Ivana, van Duijn, Cornelia M., Amin, Najaf, la Bastide-van Gemert, Sacha, de Vries, Maaike, Ward-Caviness, Cavin K., Wolf, Kathrin, Waldenberger, Melanie, Peters, Annette, Stolk, Ronald P., Brunekreef, Bert, Boezen, H. Marike, Vonk, Judith M.“…None of the seven Bonferroni significant CpG-sites were significantly replicated in the two KORA-cohorts. No associations were found for PM exposure. …”
Publicado 2018
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351por Grüneis, Rebecca, Lamina, Claudia, Di Maio, Silvia, Schönherr, Sebastian, Zoescher, Peter, Forer, Lukas, Streiter, Gertraud, Peters, Annette, Gieger, Christian, Köttgen, Anna, Kronenberg, Florian, Coassin, Stefan“…METHODS: Effects on Lp(a) concentrations were investigated by multiple quantile regression in the German Chronic Kidney Disease (GCKD) study, KORA-F3 and KORA-F4 (n(total) = 10,405) as well as in the UK Biobank (UKB) 200k exome dataset (n = 173,878). …”
Publicado 2022
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352por Attar, Homa, Bedard, Karen, Migliavacca, Eugenia, Gagnebin, Maryline, Dupré, Yann, Descombes, Patrick, Borel, Christelle, Deutsch, Samuel, Prokisch, Holger, Meitinger, Thomas, Mehta, Divya, Wichmann, Erich, Delabar, Jean Maurice, Dermitzakis, Emmanouil T., Krause, Karl-Heinz, Antonarakis, Stylianos E.“…Next, we performed genome-wide association study (GWAS) for the combined KORA-GenCord cohorts (n = 279) using enhanced marker resolution by imputation (>1.4 million SNPs). …”
Publicado 2012
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353por Menni, Cristina, Graham, Delyth, Kastenmüller, Gabi, Alharbi, Nora H.J., Alsanosi, Safaa Md, McBride, Martin, Mangino, Massimo, Titcombe, Philip, Shin, So-Youn, Psatha, Maria, Geisendorfer, Thomas, Huber, Anja, Peters, Annette, Wang-Sattler, Rui, Xu, Tao, Brosnan, Mary Julia, Trimmer, Jeff, Reichel, Christian, Mohney, Robert P., Soranzo, Nicole, Edwards, Mark H., Cooper, Cyrus, Church, Alistair C., Suhre, Karsten, Gieger, Christian, Dominiczak, Anna F., Spector, Tim D., Padmanabhan, Sandosh, Valdes, Ana M.“…The blood pressure association was replicated in KORA and Hertfordshire. In the animal experiments, we showed that oral hexadecanedioate increased both circulating hexadecanedioate and blood pressure in Wistar–Kyoto rats, whereas blood pressure elevation with oral sodium chloride in hypertensive rats did not affect hexadecanedioate levels. …”
Publicado 2015
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354por Merz, Benedikt, Nöthlings, Ute, Wahl, Simone, Haftenberger, Marjolein, Schienkiewitz, Anja, Adamski, Jerzy, Suhre, Karsten, Wang-Sattler, Rui, Grallert, Harald, Thorand, Barbara, Pischon, Tobias, Bachlechner, Ursula, Floegel, Anna, Peters, Annette, Boeing, Heiner“…METHODS: Data of 4 126 weight-gaining adults (18–75 years) from three population-based, prospective German cohort studies (EPIC, KORA, DEGS) were analysed regarding a waist-gaining (WG) or hip-gaining phenotype (HG). …”
Publicado 2016
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355por Rauh, Simone P., Heymans, Martijn W., Koopman, Anitra D. M., Nijpels, Giel, Stehouwer, Coen D., Thorand, Barbara, Rathmann, Wolfgang, Meisinger, Christa, Peters, Annette, de las Heras Gala, Tonia, Glümer, Charlotte, Pedersen, Oluf, Cederberg, Henna, Kuusisto, Johanna, Laakso, Markku, Pearson, Ewan R., Franks, Paul W., Rutters, Femke, Dekker, Jacqueline M.“…METHODS: Data from 5,762 initially non-diabetic subjects from three population-based cohorts (Hoorn Study, Inter99, KORA S4/F4) were combined to predict HbA1c levels at six year follow-up. …”
Publicado 2017
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356por Ward-Caviness, Cavin K., Agha, Golareh, Chen, Brian H., Pfeiffer, Liliane, Wilson, Rory, Wolf, Petra, Gieger, Christian, Schwartz, Joel, Vokonas, Pantel S., Hou, Lifang, Just, Allan C., Bandinelli, Stefania, Hernandez, Dena G., Singleton, Andrew B., Prokisch, Holger, Meitinger, Thomas, Kastenmüller, Gabi, Ferrucci, Luigi, Baccarelli, Andrea A., Waldenberger, Melanie, Peters, Annette“…RESULTS: Using paired samples from the KORA cohort, we screened for DNA methylation loci (CpGs) whose change in methylation is potentially indicative of the occurrence of an incident MI between the baseline and follow-up exams. …”
Publicado 2018
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357por Schlicht, Kristina, Nyczka, Piotr, Caliebe, Amke, Freitag-Wolf, Sandra, Claringbould, Annique, Franke, Lude, Võsa, Urmo, Kardia, Sharon L. R., Smith, Jennifer A., Zhao, Wei, Gieger, Christian, Peters, Annette, Prokisch, Holger, Strauch, Konstantin, Baurecht, Hansjörg, Weidinger, Stephan, Rosenstiel, Philip, Hütt, Marc-Thorsten, Knecht, Carolin, Szymczak, Silke, Krawczak, Michael“…Replication of our genome-wide significant GWAS result was successful in another population study from the Netherlands (BIOS, n = 2661; lead SNP), but failed in two additional studies (KORA, Germany, n = 711; GENOA, USA, n = 411). Besides sample size issues, we surmise that these discrepant findings may be attributable to technical differences. …”
Publicado 2019
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358por Lau, Lina Hui Ying, Nano, Jana, Prehn, Cornelia, Cecil, Alexander, Rathmann, Wolfgang, Zeller, Tanja, Lechner, Andreas, Adamski, Jerzy, Peters, Annette, Thorand, Barbara“…RESEARCH DESIGN AND METHODS: We analyzed data from the observational KORA F4 study and its follow-up examination KORA FF4 (median follow-up time 6.5 years) including 1293 men and 650 peri- and postmenopausal women, not using exogenous sex hormones. …”
Publicado 2022
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359por Nogal, Ana, Tettamanzi, Francesca, Dong, Qiuling, Louca, Panayiotis, Visconti, Alessia, Christiansen, Colette, Breuninger, Taylor, Linseisen, Jakob, Grallert, Harald, Wawro, Nina, Asnicar, Francesco, Wong, Kari, Baleanu, Andrei-Florin, Michelotti, Gregory A., Segata, Nicola, Falchi, Mario, Peters, Annette, Franks, Paul W., Bagnardi, Vincenzo, Spector, Tim D., Bell, Jordana T., Gieger, Christian, Valdes, Ana M., Menni, Cristina“…We used the Cooperative Health Research in the Region of Augsburg (KORA) cohort (318 IFG individuals, 689 healthy individuals) to replicate our findings. …”
Publicado 2023
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360por Sõber, Siim, Org, Elin, Kepp, Katrin, Juhanson, Peeter, Eyheramendy, Susana, Gieger, Christian, Lichtner, Peter, Klopp, Norman, Veldre, Gudrun, Viigimaa, Margus, Döring, Angela, Putku, Margus, Kelgo, Piret, Shaw-Hawkins, Sue, Howard, Philip, Onipinla, Abiodun, Dobson, Richard J., Newhouse, Stephen J., Brown, Morris, Dominiczak, Anna, Connell, John, Samani, Nilesh, Farrall, Martin, Caulfield, Mark J., Munroe, Patricia B., Illig, Thomas, Wichmann, H.-Erich, Meitinger, Thomas, Laan, Maris“…We used Affymetrix 500K genotyping data of KORA S3 cohort (n = 1,644; Southern-Germany) to address (i) SNP coverage in 160 BP candidate genes; (ii) the evidence for associations with BP traits in genome-wide and replication data, and haplotype analysis. …”
Publicado 2009
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