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  1. 461
    “…SNPs associated with childhood obesity (p-values ≤ 0.05) were further analysed in 8,491 adult individuals of a population-based cohort (KORA) for association with adult obesity. One SNP was further analysed in 985 German obese adults and 588 normal and underweight controls. …”
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    Mutation screen and association studies for the fatty acid amide hydrolase (FAAH) gene and early onset and adult obesity
  2. 462
    por Pfeufer, Arne, van Noord, Charlotte, Marciante, Kristin D., Arking, Dan E., Larson, Martin G., Smith, Albert Vernon, Tarasov, Kirill V., Müller, Martina, Sotoodehnia, Nona, Sinner, Moritz F., Verwoert, Germaine C., Li, Man, Kao, W.H. Linda, Köttgen, Anna, Coresh, Josef, Bis, Joshua C., Psaty, Bruce M., Rice, Kenneth, Rotter, Jerome I., Rivadeneira, Fernando, Hofman, Albert, Kors, Jan A., Stricker, Bruno H.C., Uitterlinden, André G., van Duijn, Cornelia M., Beckmann, Britt M., Sauter, Wiebke, Gieger, Christian, Lubitz, Steven A., Newton-Cheh, Christopher, Wang, Thomas J., Magnani, Jared W., Schnabel, Renate B., Chung, Mina K., Barnard, John, Smith, Jonathan D., Van Wagoner, David R., Vasan, Ramachandran S., Aspelund, Thor, Eiriksdottir, Gudny, Harris, Tamara B., Launer, Lenore J., Najjar, Samer S., Lakatta, Edward, Schlessinger, David, Uda, Manuela, Abecasis, Gonçalo R., Müller-Myhsok, Bertram, Ehret, Georg B., Boerwinkle, Eric, Chakravarti, Aravinda, Soliman, Elsayed Z., Lunetta, Kathryn L., Perz, Siegfried, Wichmann, H.-Erich, Meitinger, Thomas, Levy, Daniel, Gudnason, Vilmundur, Ellinor, Patrick T., Sanna, Serena, Kääb, Stefan, Witteman, Jacqueline C.M., Alonso, Alvaro, Benjamin, Emelia J., Heckbert, Susan R.
    Publicado 2010
    “…To identify underlying common genetic variation, we meta-analyzed genome-wide association results for PR interval from seven community-based studies of European-ancestry individuals in the CHARGE consortium: AGES, ARIC, CHS, FHS, KORA, Rotterdam Study, and SardiNIA (N=28,517). Statistically significant loci (P<5×10(-8)) were tested for association with AF (N=5,741 cases). …”
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    Genome-wide association study of PR interval
  3. 463
    “…METHODS: Between May 2003 and February 2004, 67 MI survivors from the Augsburg KORA-MI registry repeatedly sent 16 sec electrocardiograms (ECGs) with a personal transmitter (Viapac) via telephone to the Philips Monitoring Center, where ECG parameters were immediately analyzed. …”
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    Altered Cardiac Repolarization in Association with Air Pollution and Air Temperature among Myocardial Infarction Survivors
  4. 464
    “…We assess 649 blood metabolic traits from 1814 participants of the Kooperative Gesundheitsforschung in der Region Augsburg (KORA) population study for association with methylation of 457 004 CpG sites, determined on the Infinium HumanMethylation450 BeadChip platform. …”
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    Online Artículo Texto
    Epigenetics meets metabolomics: an epigenome-wide association study with blood serum metabolic traits
  5. 465
    “…Here we report the largest mGWAS to date, combining targeted and non-targeted (1)H NMR analysis of urine samples from 3,861 participants of the SHIP-0 cohort and 1,691 subjects of the KORA F4 cohort. We identified and replicated 22 loci with significant associations with urinary traits, 15 of which are new (HIBCH, CPS1, AGXT, XYLB, TKT, ETNPPL, SLC6A19, DMGDH, SLC36A2, GLDC, SLC6A13, ACSM3, SLC5A11, PNMT, SLC13A3). …”
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    Genome-Wide Association Study with Targeted and Non-targeted NMR Metabolomics Identifies 15 Novel Loci of Urinary Human Metabolic Individuality
  6. 466
    “…METHODS AND RESULTS: In a general population-based cohort study from Germany (KORA-S3) with subjects’ baseline age ranging from 25 to 74 years, cardiac morphology and function were assessed as left ventricular mass (LVM), diastolic dysfunction and EF by echocardiography and circulating NT-proBNP and BNP were measured at baseline. …”
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    NT-proBNP Predicts Cardiovascular Death in the General Population Independent of Left Ventricular Mass and Function: Insights from a Large Population-Based Study with Long-Term Follow-Up
  7. 467
    “…RESULTS: Genome-wide DNA methylation was measured in peripheral blood in 1,741 participants of the KORA F4 study using Illumina HumanMethylation450 BeadChip arrays. …”
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    Epigenetic Signatures at AQP3 and SOCS3 Engage in Low-Grade Inflammation across Different Tissues
  8. 468
    “…Using targeted metabolomics within a subsample of the German EPIC-Potsdam study (n = 2500), we tested previously published SNPs for their association with diabetes-associated metabolites and conducted an additional exploratory analysis using data from the exome chip including replication within 2,692 individuals from the German KORA F4 study. We identified a total of 16 loci associated with diabetes-related metabolite traits, including one novel association between rs499974 (MOGAT2) and a diacyl-phosphatidylcholine ratio (PC aa C40:5/PC aa C38:5). …”
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    Online Artículo Texto
    Genetic variants including markers from the exome chip and metabolite traits of type 2 diabetes
  9. 469
    “…METHODS: Data from 384 subjects (mean age: 56 years, 58% men) of a population-based cohort study (KORA) were included in a cross-sectional design. …”
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    Online Artículo Texto
    Alcohol consumption, but not smoking is associated with higher MR-derived liver fat in an asymptomatic study population
  10. 470
    “…METHODS: Among subjects of the population-based KORA-Age cohort (n = 935, 65-90y; 51% male) two groups were selected from either the lower (LED; n = 51) or the upper (UED; n = 72) end of the FEV(1) distribution. …”
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    Heterogeneous pattern of differences in respiratory parameters between elderly with either good or poor FEV(1)
  11. 471
    “…To identify genetic loci involved in IgG glycosylation, we performed a genome-wide association study (GWAS) on liquid chromatography electrospray mass spectrometry (LC–ESI-MS)—measured IgG glycopeptides of 1,823 individuals in the Cooperative Health Research in the Augsburg Region (KORA F4) study cohort. In addition, we performed GWAS on subclass-specific ratios of IgG glycans to gain power in identifying genetic factors underlying single enzymatic steps in the glycosylation pathways. …”
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    Genome-Wide Association Study on Immunoglobulin G Glycosylation Patterns
  12. 472
    “…METHODS: The analysis was based on data from the German population based KORA (Cooperative Health Research in the Region of Augsburg) Augsburg cohort study. …”
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    New indexes of body fat distribution and sex-specific risk of total and cause-specific mortality: a prospective cohort study
  13. 473
    “…METHODS: Cross-sectional data was retrieved from the population based KORA FF4 study (Cooperative Health Research in the Region of Augsburg) that was conducted in southern Germany from 2013 to 2014 (n = 2279). …”
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    Direct healthcare costs associated with device assessed and self-reported physical activity: results from a cross-sectional population-based study
  14. 474
    “…METHODS: One hundred serum metabolites were quantified in European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam (n = 2458), EPIC-Heidelberg (n = 812), KORA (Cooperative Health Research in the Augsburg Region) (n = 3029) and CARLA (Cardiovascular Disease, Living and Ageing in Halle) (n = 1427) with targeted metabolomics. …”
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    Online Artículo Texto
    Comparison of metabolite networks from four German population-based studies
  15. 475
    “…We therefore investigated the influence of long-term storage on levels of eight circulating miRNAs (miR-103a-3p, miR-191-5p, miR-124-3p, miR-30c-5p, miR-451a, miR-23a-3p, miR-93-5p, miR-24-3p, and miR-33b-5p) from 10 participants from the population-based cohort study KORA. Sample collection took place during the baseline survey S4 and the follow-up surveys F4 and FF4, over a time period spanning from 1999 to 2014. …”
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    Online Artículo Texto
    Impact of long-term storage and freeze-thawing on eight circulating microRNAs in plasma samples
  16. 476
    “…The methylation analyses were replicated in the independent KORA cohort (n = 890) and a meta-analysis of the two studies was conducted. …”
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    Subjective mental health, incidence of depressive symptoms in later life, and the role of epigenetics: results from two longitudinal cohort studies
  17. 477
    “…To evaluate the relationship of cardiac function, including time-volume-curves, with lung volumes derived from pulmonary function tests (PFT) and MRI in subjects without cardiovascular diseases. 216 subjects underwent whole-body MRI and spirometry as part of the KORA-FF4 cohort study. Lung volumes derived semi-automatically using an in-house algorithm. …”
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    Subclinical cardiac impairment relates to traditional pulmonary function test parameters and lung volume as derived from whole-body MRI in a population-based cohort study
  18. 478
    “…In line with these findings, plasma BCAA levels were positively correlated to electrocardiogram indices of conduction and repolarization in the German community-based KORA F4 Study. Isolated cardiomyocytes from Bcat2(p.Q300*/p.Q300*) mice revealed action potential (AP) prolongation, pro-arrhythmic events (early and late afterdepolarizations, triggered APs), and dysregulated calcium homeostasis. …”
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    Chronically elevated branched chain amino acid levels are pro-arrhythmic
  19. 479
    “…We pooled four waves of the KORA study, carried out between 1984 and 1996 (N = 14,592). …”
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    The effect of population-based blood pressure screening on long-term cardiometabolic morbidity and mortality in Germany: A regression discontinuity analysis
  20. 480
    “…We examined predictive value of combination of the Liver function tests (gamma-glutamyltransferase, alanine aminotransferase, aspartate aminotransferase and albumin) above validated models for 7.5-year risk of diabetes (the Cooperative Health Research in the Region of Augsburg, the KORA study). Basic model includes age, sex, BMI, smoking, hypertension and parental diabetes. …”
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    Liver Function Tests and Risk Prediction of Incident Type 2 Diabetes: Evaluation in Two Independent Cohorts
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