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2601“…Here we show that telomere deregulation leads to enlarged, misshapen “monster” cells with increased DNA content and apparent defects in cell division. …”
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2602
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2603
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2604por Nieto, Marta, Frade, José M.R., Sancho, David, Mellado, Mario, Martinez-A, Carlos, Sánchez-Madrid, Francisco“…Chemokine receptor expression on the leading edge of migrating polarized lymphocytes appears to act as a sensor mechanism for the directed migration of leukocytes through a chemoattractant gradient.…”
Publicado 1997
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2605
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2606
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2607Preferential attachment of membrane glycoproteins to the cytoskeleton at the leading edge of lamellaPublicado 1991“…Fluorescent succinylated Con A staining showed no corresponding concentration of general glycoproteins at the leading edge, but cytochalasin D-resistant filamentous actin was found at the leading edge. …”
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2608
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2609por Fajac, Isabelle, Viel, Marion, Sublemontier, Sébastien, Hubert, Dominique, Bienvenu, Thierry“…CONCLUSION: Our results suggest that several variants in ENaCβ and γ genes might be deleterious for ENaC function and lead to bronchiectasis, especially in patients who are trans-heterozygotes for ENaCβ/CFTR mutations or variants.…”
Publicado 2008
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2610por Hauser, Russ, Sergeyev, Oleg, Korrick, Susan, Lee, Mary M., Revich, Boris, Gitin, Elena, Burns, Jane S., Williams, Paige L.“…We used multivariable linear regression models to assess associations of blood lead levels with somatic growth at the study entry visit. …”
Publicado 2008
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2611
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2612“…Wounding of plants leads to endogenous rise of jasmonic acid (JA) accompanied with the expression of a distinct set of genes. …”
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2613
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2614por Salukhe, Tushar V, Wright, Ian, Wright, Matthew, Kanagaratnam, Prapa, O'Neill, Mark D“…We report an interesting case of pectoral muscle myopotential oversensing causing inhibition of bradycardia pacing leading to presyncope and syncope.…”
Publicado 2008
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2615
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2616por Hefti, Franz F“…A drug candidate suitable for clinical testing is expected to bind selectively to the receptor site on the target, to elicit the desired functional response of the target molecule, and to have adequate bioavailability and biodistribution to elicit the desired responses in animals and humans; it must also pass formal toxicity evaluation in animals. The path from lead to clinical drug candidate represents the most idiosyncratic segment of drug discovery and development. …”
Publicado 2008
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2617
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2618
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2619por Weuve, Jennifer, Korrick, Susan A., Weisskopf, Marc A., Ryan, Louise M., Schwartz, Joel, Nie, Huiling, Grodstein, Francine, Hu, Howard“…METHODS: Patella and tibia bone lead—measures of cumulative exposure over many years—and blood lead, a measure of recent exposure, were assessed in 587 women 47–74 years of age. …”
Publicado 2009
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2620