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451“…Considerable controversy exists concerning the possible role of lead in the etiology of human hypertension. In animal studies, there is convincing evidence that lead alters cardiovascular responsiveness; rats drinking water containing 100 ppm lead develop a chronic, significant 15 to 20 mm Hg elevation in systolic blood pressure. …”
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452“…Current questions about lead exposure focus on the consequences of levels too low to have erupted into blatantly discernible defects. …”
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453por Goyer, R A“…The mechanism(s) for the central nervous system effects of lead is unclear but involve lead interactions within calcium-mediated intracellular messenger systems and neurotransmission. …”
Publicado 1993
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454
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456por Needleman, H L“…Five decades ago, lead toxicity in childhood was thought in nonlethal cases to be without residual effect. …”
Publicado 1990
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457por Levander, O A“…Under appropriate conditions, deficiencies of certain minerals and vitamins as well as high intakes of dietary fat increase the toxicity of a given dose of lead in experimental animals. The severity of lead poisoning can also be increased by the consumption of either deficient or excessive levels of protein. …”
Publicado 1979
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458por Posner, H S“…This review is concerned with the concentrations of lead in human whole blood, erythrocytes, plasma, serum, soft tissues, bone, and urine. …”
Publicado 1977
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459“…Major strides have been taken in the regulation of lead intoxication in the general population, but studies using genetic markers of susceptibility to environmental toxicants raise the question of whether genes can make certain individuals more vulnerable to environmental toxins such as lead. …”
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