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  1. 486661
    por Starska-Kowarska, Katarzyna
    Publicado 2023
    “…Since approximately 60–70% of patients present with stage III/IV neoplastic disease, HNSCC is still one of the leading causes of death in cancer patients worldwide, with an overall survival rate that is too low, not exceeding 40–60% of these patients. …”
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    Role of Vitamin D in Head and Neck Cancer—Immune Function, Anti-Tumour Effect, and Its Impact on Patient Prognosis
  2. 486662
    por Xu, Ping, Fu, Qiang, Zhao, Meihui
    Publicado 2023
    “…Consequently, the amount of Cu(ii) converted to Cu(2)O decreases, leading to an increase in Cu(ii) in the solution. …”
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    The influence of calcium on copper corrosion and its by-product release in drinking water
  3. 486663
    “…Background: Cystic fibrosis (CF) is caused by a wide spectrum of mutations in the CF transmembrane conductance regulator (CFTR) gene, with some leading to non-classical clinical presentations. We present an integrated in vivo, in silico and in vitro investigation of an individual with CF carrying the rare Q1291H-CFTR allele and the common F508del allele. …”
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    Q1291H-CFTR molecular dynamics simulations and ex vivo theratyping in nasal epithelial models and clinical response to elexacaftor/tezacaftor/ivacaftor in a Q1291H/F508del patient
  4. 486664
    “…Sows mobilize body reserves during gestation and lactation due to nutrients being prioritized for lactation purposes while feeding piglets, which generally leads to metabolism and immunity undergoing drastic changes. …”
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    Fermented Bamboo Fiber Improves Productive Performance by Regulating Gut Microbiota and Inhibiting Chronic Inflammation of Sows and Piglets during Late Gestation and Lactation
  5. 486665
    “…Poor knowledge of conception probability period leads to undesirable outcomes like unwanted pregnancy, miscarriage, and abortion. …”
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    Determinants of knowledge of the highest conception probability period among reproductive age women in Low-Income African countries: A multilevel analysis based on the recent Demographic and Health Survey
  6. 486666
    “…They also have a lower proportion of early-stage cases, treatment at provincial or municipal hospitals, and surgical treatment, leading to poorer survival outcomes (HR=1.57). Even when considering factors such as gender, age, residential location, clinical stage at diagnosis, histological type, hospital level of service, and surgical intervention, peasants still exhibit a survival disadvantage. …”
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    滇东产煤区农民住院肺癌病例长期生存分析
  7. 486667
    “…R175H mutation was considered structural mutation where the mutation causes misfolding of the protein and leads to a significant conformational alterations within p53's DNA binding domain. …”
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    TP53 mutations predict poor response to immunotherapy in patients with metastatic solid tumors
  8. 486668
    “…AIMS: Left ventricular remodelling occurs during the chronic course of aortic regurgitation (AR) and aortic stenosis (AS), leading to myocardial hypertrophy and fibrosis. Several studies have shown that extracellular volume fraction (ECV) and indexed extracellular volume (iECV) are important surrogate markers of diffuse myocardial fibrosis (MF). …”
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    Postoperative myocardial fibrosis assessment in aortic valvular heart diseases—a cardiovascular magnetic resonance study
  9. 486669
    “…We observed that CDH1 depletion leads to novel genomic interactions between the CDH1 and CDH3 gene sequences. …”
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    3D Chromatin Architecture Re-Wiring at the CDH3/CDH1 Loci Contributes to E-Cadherin to P-Cadherin Expression Switch in Gastric Cancer
  10. 486670
    “…SIMPLE SUMMARY: Alzheimer’s Disease (AD) is a leading cause of death and disability worldwide. Unfortunately, medical researchers have struggled to develop methods to understand why some people develop AD while others do not while also focusing on the disease’s late-stage consequences. …”
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    Neural Differentiation of Induced Pluripotent Stem Cells for a Xenogeneic Material-Free 3D Neurological Disease Model Neurulation from Pluripotent Cells Using a Human Hydrogel
  11. 486671
    “…Gd(3+) and Sm(3+) co-activation leads to a notable decreasing intensity of the charge transfer band in comparison with Gd(3+) single-doped phases. …”
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    Novel Red Phosphor of Gd(3+), Sm(3+) co-Activated Ag(x)Gd(((2−x)/3)−0.3−y)Sm(y)Eu(3+)(0.30)☐((1−2x−2y)/3)WO(4) Scheelites for LED Lighting
  12. 486672
    “…The timely delivery of PPCI became extremely challenging for STEMI patients during the coronavirus disease 2019 (COVID-19) pandemic, leading to a projected steep rise in mortality. These delays were overcome by the shift from first-line therapy and the development of modern fibrinolytic-based reperfusion. …”
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    Effect of fibrinolytic therapy on ST-elevation myocardial infarction clinical outcomes during the COVID-19 pandemic: A systematic review and meta-analysis
  13. 486673
    “…Notably, just two doses of Anti-C5 only on PTD-0 and -3 significantly improved biliary injury and liver fibrosis up to PTD-100, leading to better long-term animal survival (P =0.02). …”
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    Anti-complement 5 antibody ameliorates antibody-mediated rejection after liver transplantation in rats
  14. 486674
    “…OBJECTIVE: Inflammatory cardiomyopathy is characterised by inflammatory infiltrates leading to cardiac injury, left ventricular (LV) dilatation and reduced LV ejection fraction (LVEF). …”
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    FOXO3A acts as immune response modulator in human virus-negative inflammatory cardiomyopathy
  15. 486675
    “…IMPORTANCE: Although deaths due to external causes are a leading cause of mortality in the US, trends over time by intent and demographic characteristics remain poorly understood. …”
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    Trends in Mortality From Poisonings, Firearms, and All Other Injuries by Intent in the US, 1999-2020
  16. 486676
    “…Although chemotherapy combined with vascular endothelial growth factor inhibitors significantly improves progression-free survival (PFS) in TKI-resistant patients, it often cannot be tolerated in elderly patients, leading to treatment failure. Anlotinib is a small molecule inhibitor made in China. …”
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    Low‑dose anlotinib combined with EGFR‑TKI can be used as an alternative for EGFR‑TKI‑resistant non‑small cell lung cancer in elderly patients
  17. 486677
    “…For EM residents, this leads to inefficient and uncomfortable encounters with patients with eye complaints. …”
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    Use of An Ophthalmology Tutorial to Improve Resident Comfort with the Emergency Eye Exam
  18. 486678
    “…Nonadherence to topical treatments for acne is common and often leads to treatment failure. OBJECTIVE: The aim of this study is to develop a web-based behavioral intervention to support the self-management of acne and to assess the feasibility of recruitment, retention, and engagement of users with the intervention. …”
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    Supporting Self-management Among Young People With Acne Vulgaris Through a Web-Based Behavioral Intervention: Development and Feasibility Randomized Controlled Trial
  19. 486679
    “…Topic 1 was related to users’ concerns about leading a healthier lifestyle and the potential impacts of fluoride consumption, including its hypothetical toxicity. …”
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    Analysis of Fluoride-Free Content on Twitter: Topic Modeling Study
  20. 486680
    “…In addition, the lack of a secure legal basis for the research and use of medical AI in the European Union leads doctors to expect problems with legal liability (186/701, 27% strongly agreed, and 374/701, 53% agreed) and data protection (148/701, 21% strongly agreed, and 343/701, 49% agreed). …”
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    Expectations of Anesthesiology and Intensive Care Professionals Toward Artificial Intelligence: Observational Study
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