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  1. 486741
    “…Following artifact rejection, sleep qEEG analysis was conducted on frontal and central leads. The measures included slow wave (SW) and spindle density and morphological characteristics, SW-spindle phase-amplitude coupling, and spectral power analysis during non-rapid eye movement (NREM) sleep. …”
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    Effects of deep brain stimulation on quantitative sleep electroencephalogram during non-rapid eye movement in Parkinson’s disease
  2. 486742
    “…IMPORTANCE: Respiratory syncytial virus (RSV) is a leading cause of pediatric hospitalizations. OBJECTIVE: To describe the epidemiology and burden of RSV-associated hospitalizations among children and adolescents in Canadian tertiary pediatric hospitals from 2017 to 2022, including changes during the COVID-19 pandemic. …”
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    Pediatric RSV-Associated Hospitalizations Before and During the COVID-19 Pandemic
  3. 486743
    “…BACKGROUND: Suicide is the fourth leading cause of death among young people aged 15-29 years worldwide and suicide rates are increasing. …”
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    Developing Suicide Prevention Tools in the Context of Digital Peer Support: Qualitative Analysis of a Workshop With Multidisciplinary Stakeholders
  4. 486744
    “…Interestingly, chronic hypoxia in amyloid goiters has been hypothesized to cause fibroblast-to-adipocyte metaplasia leading to DTL. We speculate that excess thyroid hormone release could also be mediated by follicular cells’ response to hypoxia induced by amyloid and fatty infiltration of the thyroid. …”
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    SAT473 First Case Of Diffuse Thyroid Lipomatosis With Amyloid Deposits Presenting With Hyperthyroidism
  5. 486745
    “…The first 4 weeks after surgery are the period most susceptible to thromboembolism due to the worsening of the coagulation profile associated with the sudden reduction in the level of cortisol and its anti-inflammatory activity, leading to a thrombotic and inflammatory state. Case report: A 28-year-old woman, evaluated for bariatric surgery, was admitted to the emergency department complaining of dyspnea and palpitations that had started the day before. …”
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    SAT324 Pulmonary Embolism Before And After Transsphenoidal Surgery In Cushing's Disease: Case Report.
  6. 486746
    “…In type 1 diabetes (T1D) autoimmune destruction of pancreatic islet β-cells causes a lack of insulin, leading to hyperglycemia. The development of therapies that can prevent β-cell death is critical. β-cell proliferation and survival pathways are affected by signaling through G protein-coupled receptors (GPCRs). …”
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    SAT069 Targeting Human β-Cell G Protein-coupled Receptors To Alter Cytokine-mediated Caspase Activation
  7. 486747
    “…However, glucocorticoid excess (GE) causes severe metabolic dysfunction, ultimately leading to Cushing’s Syndrome. This dysfunction is often dependent on the presence of the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). …”
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    SAT276 Glucocorticoid Excess Elevates Metabolic Rate Via A 11b-HSD1 Dependent Mechanism In C57BL/6J Mice
  8. 486748
    “…Currently, there remains an undefined consensus guideline in the diagnosis and management of this disorder that leads to unreported cases. Clinical Case: A 47-year-old male presented with 2-day history of poor dietary intake due to abdominal pain and vomiting after an alcoholic binge drinking. …”
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    SAT160 Alcoholic Ketoacidosis : An Endocrine Emergency
  9. 486749
    “…The procedure was complicated by T11/T12 intercostal artery injury leading to hemothorax. He was continued on physiologic doses of hydrocortisone. …”
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    SAT323 Management Of Severe Cushing’s Syndrome Due To Cortisol Secreting Adrenal Tumor In A Critically Ill Patient
  10. 486750
    “…Thus, 27HC increases the size of multivesicular bodies, impairs lysosomal integrity, and alters levels of ISG- and NEDDylated proteins in cells, and a combination of these modulations leads to the increase in EV secretion. Collectively, our studies reveal novel mechanisms by which EV secretion is modulated by 27HC. …”
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    THU482 The Cholesterol Metabolite, 27-hydroxycholesterol, Enhances The Secretion Of Cancer Promoting Extracellular Vesicles By Impairing Lysosomal Integrity
  11. 486751
    “…This mutation is known to increase affinity for glucose, which leads to exaggerated insulin secretion. Conclusion: Our study highlights that in adults with non-insulinoma pancreatogenous hypoglycemia, genetic causes of HH should be considered in the differential diagnosis. …”
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    SAT163 Title: Adult-onset Hyperinsulinemic Hypoglycemia Due To An Activating Mutation In Glucokinase
  12. 486752
    “…Although there was no statisticallysignificant difference between the survivors and non-survivors concerning meanHbA1C and RBS levels, there was a statistically significant association betweenthe Stage of Mucormycosis and the level of HbA1c and RBS at presentation forStages 2b, 2c, 2d,3a, 3b, 3c, 4a, 4b, and 4c. This leads to the understandingthat clinicians must order blood sugar and HbA1c level at presentation as cuesto a better understanding of disease severity. …”
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    THU330 No Calm After The Storm : Is Blood Glucose Level At Patient Presentation Related To The Stage And Outcome Of Mucormycosis In COVID- 19 Pandemic?
  13. 486753
    “…In response to glucose elevation or other physiological stimuli, pancreatic islet β cells are excited to mobilize intracellular Ca(2+) leading to insulin secretion, which is a complex cellular event with underlying mechanisms not fully elucidated. …”
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    SAT061 Deficiency Of ENaC Excites Pancreatic β Cells To Promote Insulin Secretion
  14. 486754
    “…Left untreated, continued exposure to increased levels of growth hormone and IGF-1 leads to development of comorbidities including Cushing’s disease, cardiovascular disease, diabetes, arthralgias, decreased bone mineral density, sleep apnea, and uterine leiomyomata, as well as increased mortality and decreased quality of life. …”
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    THU022 A Case Of Delayed Diagnosis Of Acromegaly
  15. 486755
    por Thirunagari, Rajeev, Taha, Doris R
    Publicado 2023
    “…It is due to excessive production of type 3 iodothyronine deiodinase (D3) enzyme by the hemangioma leading to increased rate of deiodination of T4 and T3 to inactive forms. …”
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    THU230 Consumptive Hypothyroidism Secondary To Hemangioma
  16. 486756
    “…Recently, growing evidence indicates that defects in the splicing-process are frequent in cancer, leading to the appearance of altered spliceosome components (SCs), splicing-factors (SFs) and/or aberrant splicing-variants (SVs), which are associated with the development/progression/aggressiveness of various cancer types. …”
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    THU080 Splicing Machinery Dysregulation As A Source Of Novel Diagnostic, Prognostic And Therapeutic Targets In Craniopharyngiomas
  17. 486757
    “…Background: Opioid suppression of the hypothalamic-pituitary-adrenal (HPA) axis via inhibition of corticotropin releasing hormone secretion leading to secondary adrenal insufficiency (AI) has been described in literature. …”
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    THU624 Opioid Induced Adrenal Insufficiency (OIAI) Presenting With Altered Mental Status
  18. 486758
    “…Abiraterone treatment results in cortisol deficiency, with the compensatory elevation of ACTH level leading to hypokalemia, fluid retention, and hypertension due to excess mineralocorticoid. …”
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    THU579 Severe Hypokalemia: Is It Mineralocorticoid Excess Induced By Abiraterone Or Exogenous Hypercortisolism?
  19. 486759
    “…Moreover, Gata2, Nhlh2, NeuroD1, and Sox11 target 117 genes in controls and 263 genes in mutants, implying a more restricted ability of Gata2, Nhlh2, NeuroD1, and/or Sox11 to target gene expression in the presence of leptin signaling in controls, as an abrogation of leptin signaling leads to an expansion of the regulatory network in Lepr-null mutant gonadotropes. …”
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    OR20-03 Leptin-mediated Regulation Of Gene Regulatory Networks In Gonadotropes
  20. 486760
    “…Altogether, our study uses spatial transcriptomics of the normal human adrenal and the results have important implications for the differentiation and functional zonation,as well as, for the early dysregulation leading to primary aldosteronism. Presentation: Friday, June 16, 2023…”
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    OR08-02 In Situ Reconstruction Of Distinct Normal And Pathological Cell Populations Within The Human Adrenal Gland Using Spatial Transcriptomics
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