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  1. 486781
    por Sekar, Vijaykumar, Shaik, Shamsuddin
    Publicado 2023
    “…Use of insulin to treat hyperglycemia was shown to partially reactivate the PI3K pathway in tumoral cells, leading to cellular proliferation. Therefore, insulin should be kept as the last line antihyperglycemic agent. …”
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    THU380 A Case Of Alpelisib Induced Diabetic Ketoacidosis (Dka) In A Patient With Type 2 Diabetes Mellitus And Rechallenge With SGLT2 Inhibitor
  2. 486782
    “…Graves’ disease (GD) with onset in childhood or adolescence is a pediatric rare disease (ORPHA:525731) with a ten times lower incidence than in adults. Leading clinical signs of hyperthyroidism are sinus tachycardia, weight loss, tremor, and goiter. …”
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    FRI478 Pharmacometrics-based Computer Model Utilizing Heart Rate To Monitor Thyroid Function In Children With Graves' Disease
  3. 486783
    “…However, stopping denosumab leads to rebound bone mineral density(BMD) loss. …”
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    OR13-05 Longitudinal Changes In Bone Turnover Following Withdrawal Of RANKL Inhibition
  4. 486784
    “…Patients can often be prescribed multiple max-dosed antihypertensives with varying results and adverse effects and still spend years with uncontrolled HTN leading to long term health concerns. Hyperaldosteronism is diagnosed for resistant HTN in 4% of primary care patients and 10% endocrinology-referred patients. …”
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    FRI197 Patient Suffering From Resistant HTN For 15 Years With Negative CT Diagnosed With Hyperaldosteronism Due To Adrenal Cortical Adenoma
  5. 486785
    “…She had a history of food-seeking behavior, leading to progressive weight gain, which was managed by blocking access to food, such as locking the fridge. …”
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    SAT673 Novel Mutation Of TBX3 Associated With Morbid Obesity In Human
  6. 486786
    “…DISCUSSION: Prolonged untreated hyperthyroidism leads to high output heart failure characterized by an increase in heart rate, cardiac contractility and cardiac output which in some cases progresses to dilated cardiomyopathy with impaired left ventricular systolic function. …”
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    FRI506 Severe Dilated Cardiomyopathy As First Manifestation Of Thyrotoxicosis- A Case Report
  7. 486787
    “…We report a rare case of metastatic PTC with concomitant GD leading to symptomatic hyperthyroidism despite total thyroidectomy. …”
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    SAT553 A Case of Metastatic Functional Papillary Thyroid Cancer in the Setting of Graves’ Disease
  8. 486788
    “…Taken together, it was shown that OXT enhances ovarian progesterone production with upregulation of BMP-15 activity, leading to a fine-tuning of ovarian steroidogenesis. …”
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    FRI392 Functional Interrelationship Between Oxytocin And Bone Morphogenetic Proteins In Ovarian Steroidogenesis By Granulosa Cells
  9. 486789
    “…Background: Genetic mutation in the thyroid hormone receptor leads to the reduced affinity of hormone binding; thus, causing thyroid hormone resistance. …”
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    FRI496 A Rare Case Of Thyroid Hormone Resistance Beta
  10. 486790
    “…Reduced GNG may be mediated by improved insulin sensitivity leading to reductions in alanine and lactate, which are carbon sources for GNG. …”
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    OR18-04 Leptin Decreases Gluconeogenesis And Gluconeogenic Substrate Availability In Patients With Lipodystrophy
  11. 486791
    “…OBJECTIVE:  The overall aim is to gain a better understanding of the complex dynamic process leading to clinical professionals’ and managers’ fear of reprisal in their change agent actions and senior administrators’ and managers’ determination of wrongdoing. …”
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    Fear of Reprisal and Change Agency in the Public Health and Social Service System: Protocol for a Sequential Mixed Methods Study
  12. 486792
    “…However, the large volume of information of varying quality often confused patients, leading dermatologists to assume the role of evaluating information from preinformed patients. …”
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    Impact of Digital Media on the Patient Journey and Patient-Physician Relationship Among Dermatologists and Adult Patients With Skin Diseases: Qualitative Interview Study
  13. 486793
    “…AIMS: Suboptimal perfusion leading to heart failure (HF) often occurs after ST‐segment elevation myocardial infarction (STEMI), despite restoration of epicardial coronary flow in primary percutaneous coronary intervention (PPCI) era. …”
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    Angio‐based coronary functional assessment predicts 30‐day new‐onset heart failure after acute myocardial infarction
  14. 486794
    “…CONCLUSIONS: Lower LVEF was significantly associated with the higher incidence of HF hospitalization in AF patients without pre‐existing HF, leading to the future risk stratification for and prevention of incident HF in AF patients.…”
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    Utility of left ventricular ejection fraction in atrial fibrillation patients without pre‐existing heart failure
  15. 486795
    “…Cdon ablation causes alterations in neurotrophin signalling that leads to motor neuron degeneration.…”
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    Cdon ablation in motor neurons causes age‐related motor neuron degeneration and impaired sciatic nerve repair
  16. 486796
    “…All of this has led to changes in the T category of the TNM classification, leading to an increase in staging and possible adjustments in the management of adjuvant treatments. …”
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    Depth of Invasion: Influence of the Latest TNM Classification on the Prognosis of Clinical Early Stages of Oral Tongue Squamous Cell Carcinoma and Its Association with Other Histological Risk Factors
  17. 486797
    “…BACKGROUND: Heart failure (HF) is one of the leading causes of hospital admissions. Clinical (eg, complex comorbidities and low ejection fraction) and social needs factors (eg, access to transportation, food security, and housing security) have both contributed to hospitalizations, emphasizing the importance of increased clinical and social needs support at home. …”
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    Feasibility and Acceptability of a Combined Digital Platform and Community Health Worker Intervention for Patients With Heart Failure: Single-Arm Pilot Study
  18. 486798
    “…Lack of negative control groups in published studies and intrinsic sealing mechanisms of healthy animal lungs might contribute to a translational gap, leading to poor clinical results. This study aims to address the impact of intrinsic sealing mechanisms on the validity of PAL models, and investigate the conditions required for an ovine model of PAL for lung sealant testing. …”
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    Intrinsic pulmonary sealing, its mechanisms and impact on validity and translational value of lung sealant studies: a pooled analysis of animal studies
  19. 486799
    “…BACKGROUND: Coronary heart disease (CHD) remains the leading cause of death in Australia, with a high residual risk of repeat events in survivors. …”
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    Initial Implementation of the My Heart, My Life Program by the National Heart Foundation of Australia: Pilot Mixed Methods Evaluation Study
  20. 486800
    “…No participants experienced a treatment-related TEAE leading to study withdrawal. Invasive infections were observed in 28 participants (8%); those with identified pathogens were unrelated to SER-109 species, and all were deemed unrelated to treatment by the investigators. …”
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    Integrated safety analysis of phase 3 studies for investigational microbiome therapeutic, SER-109, in recurrent CDI
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