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  1. 486841
    “…BACKGROUND: An accumulation of somatic mutations in tumors leads to increased neoantigen levels and antitumor immune response. …”
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    Evaluation of tissue- and plasma-derived tumor mutational burden (TMB) and genomic alterations of interest in CheckMate 848, a study of nivolumab combined with ipilimumab and nivolumab alone in patients with advanced or metastatic solid tumors with high TMB
  2. 486842
    “…It is the most traumatic disorder among central nervous system (CNS) conditions which not only leads to psychological and physical harm to patients but also results in a dramatic loss in the life quality. …”
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    Advances in Management of Spinal Cord Injury Using Stem Cell-derived Extracellular Vesicles: A Review Study
  3. 486843
    “…CONCLUSIONS: Our study demonstrated that HKL could partially protect against colitis by regulating Th17 differentiation through activating SIRT3, leading to inhibition of the STAT3/RORγt signaling pathway. …”
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    SIRT3 Activator Honokiol Inhibits Th17 Cell Differentiation and Alleviates Colitis
  4. 486844
    por Maliphant, John, Scott, Jenny
    Publicado 2005
    “…Problems following safer injecting advice were identified, including dexterity difficulties leading to fear of losing the 'hit'. Health problems at the groin site did not deter use. …”
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    Use of the femoral vein ('groin injecting') by a sample of needle exchange clients in Bristol, UK
  5. 486845
    “…CONCLUSION: It suggests that Pro has a wider spectrum of cytotoxic effects against human tumor cells than other bisdioxopiperazines, especially against solid tumors, and with a single cytotoxic pathway of Pro and MST-16 affecting chromosome segregation and leading also to cell G(2)/ M phase arrests, which finally reduces cell division rates. …”
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    Anti-proliferative effects, cell cycle G(2)/M phase arrest and blocking of chromosome segregation by probimane and MST-16 in human tumor cell lines
  6. 486846
    “…Consequently, female rats that are devoid of feminostatin will secrete feminizing factor from the pituitary, leading to a feminine type of hepatic metabolism. …”
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    Role of the hypothalamo-pituitary-liver axis in sex differences in susceptibility of the liver to toxic agents
  7. 486847
    por Zhao, Xin, Cheung, Leo Wang-Kit
    Publicado 2007
    “…Furthermore, linear model based algorithms often involve calculating the inverse of a matrix that is possibly singular when the number of potentially important genes is relatively large. This leads to problems of numerical instability. To overcome these limitations, a few non-linear methods have recently been introduced to the area. …”
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    Kernel-imbedded Gaussian processes for disease classification using microarray gene expression data
  8. 486848
    “…OBJECTIVES: The metabolic syndrome is a cluster of cardiovascular risk factors leading to an increased risk for the subsequent development of diabetes and cardiovascular morbidity and mortality. …”
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    Irbesartan for the treatment of hypertension in patients with the metabolic syndrome: A sub analysis of the Treat to Target post authorization survey. Prospective observational, two armed study in 14,200 patients
  9. 486849
    “…Heart disease and stroke are the first and third leading causes of death in the United States. Prior investigations have reported several single gene variants associated with CHD, stroke, HF, and AF. …”
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    Framingham Heart Study 100K project: genome-wide associations for cardiovascular disease outcomes
  10. 486850
    por Pollack, Herbert
    Publicado 1928
    “…The fact that practically the same effects can be obtained in both cases leads one to suspect that there is a relation between the results of an increase in sodium ions and a decrease in calcium ions. …”
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    MICRURGICAL STUDIES IN CELL PHYSIOLOGY : VI. CALCIUM IONS IN LIVING PROTOPLASM.
  11. 486851
    por Lloyd, David P. C., McIntyre, A. K.
    Publicado 1949
    “…A relation exists between the sequence of dorsal root potentials and the cord potential sequence, the major departure from exact correspondence occurring in the region of D.R.IV and the negative intermediary potential and being of a nature to suggest that different aspects of internuncial activity are emphasized by the two methods of leading.…”
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    ON THE ORIGINS OF DORSAL ROOT POTENTIALS
  12. 486852
    por Joseph, P., Jaiswal, A. K.
    Publicado 1998
    “…This indicates that redox cycling of the semiquinone leading to the generation of reactive oxygen species (ROS) was directly responsible for the increased mutation frequency of P450 reductase-activated BP-3,6-Q. …”
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    NAD(P)H:quinone oxidoreductase 1 reduces the mutagenicity of DNA caused by NADPH:P450 reductase-activated metabolites of benzo(a)pyrene quinones.
  13. 486853
    “…CONCLUSION: The three leading causes of diseases were cancer, CHD and stroke, and COPD. …”
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    All-cause mortality and risk factors in a cohort of retired military male veterans, Xi'an, China: an 18-year follow up study
  14. 486854
    “…Apparently, this loss of chaperone activity was due to oxidative changes leading to its greater structural alteration compared to other αB-species.…”
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    UV-A-induced structural and functional changes in human lens deamidated αB-crystallin
  15. 486855
    “…Blood specimens were collected from all suspected cases (within 14 days of onset of symptoms) and tested at a central laboratory for yellow fever IgM antibodies; leading to confirmation of yellow fever outbreaks in the health districts of Bafia, Méri and Ntui in 2003, Ngaoundéré Rural in 2004, Yoko in 2005 and Messamena in 2006. …”
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    Yellow fever control in Cameroon: Where are we now and where are we going?
  16. 486856
    “…BACKGROUND: HIV is a leading cause of morbidity and mortality in Zambia. …”
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    Harmful lifestyles' clustering among sexually active in-school adolescents in Zambia
  17. 486857
    por Ikezoe, T, Yang, Y, Taguchi, H, Koeffler, H P
    Publicado 2004
    “…Taken together, TPA, probably by stimulation of PKC, phosphorylates JNK, which phosphorylates and increases expression of c-Jun leading to AP-1 activity. Growth control of prostate cancer cells can be mediated through the JNK/c-Jun pathway, but androgen responsiveness of these cells can be independent of this pathway, suggesting that androgen independence in progressive prostate cancer may not occur through activation of this pathway.…”
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    JNK interacting protein 1 (JIP-1) protects LNCaP prostate cancer cells from growth arrest and apoptosis mediated by 12-0-tetradecanoylphorbol-13-acetate (TPA)
  18. 486858
    “…INTRODUCTION: Rheumatoid arthritis (RA) is associated with altered metabolism leading to muscle wasting. In the general population, cigarette smoking is known to affect body composition by reducing fat and inhibiting muscle synthesis. …”
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    Cigarette smoking associates with body weight and muscle mass of patients with rheumatoid arthritis: a cross-sectional, observational study
  19. 486859
    “…When biomarker secretion by healthy cells and tumor cells was assumed, the calculated tumor sizes leading to positive test results ranged between 116.7 mm(3) and 1.52 × 10(6) mm(3) for CA125 and between 27 mm(3) and 3.45 × 10(5) mm(3) for PSA. …”
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    Cancer Screening: A Mathematical Model Relating Secreted Blood Biomarker Levels to Tumor Sizes
  20. 486860
    “…One individual was found to carry a 12 kb deletion in one copy of the ASPA gene on 17p13, which when mutated in both alleles leads to Canavan disease. Two subjects showed partial duplication of the TM4SF2 gene on Xp11.4, previously implicated in X-linked non-specific mental retardation, but in our subsequent analyses such variants were also found in controls. …”
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    Multiplex ligation-dependent probe amplification for genetic screening in autism spectrum disorders: Efficient identification of known microduplications and identification of a novel microduplication in ASMT
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