“…PatientsLikeMe and 23andMe are the leading operators of researcher-organized, crowdsourced health research studies. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Blood pressure is considered to be a leading example of a valid surrogate endpoint. The aims of this study were to (i) formally evaluate systolic and diastolic blood pressure reduction as a surrogate endpoint for stroke prevention and (ii) determine what blood pressure reduction would predict a stroke benefit. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Diarrhea is a leading cause of childhood morbidity and mortality in sub-Saharan Africa. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…AIM: Pro- and anti-inflammatory processes are crucial in different phases of wound healing and their disturbances interfere with tissue homeostasis after the manifestation of ulcers, leading to chronic non-healing wounds. However, data on the association between infl ammation and acute foot syndrome are scarce. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The expected years with disability would remain unchanged while the HLY/LE ratio would improve leading to a 0.5% gain for both genders. Under expansion of morbidity, life expectancy would increase by 2.1 years for men and 1.4 years for women by 2020, while HLY would remain unchanged and the expected years with disability would increase by 2.1 years and 1.6 years in women. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Heart involvement, which is present at diagnosis in more than 50% of patients, leading to restrictive cardiopathy, is the most serious complication and engages prognosis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: The emergence of resistance to first line antiretroviral therapy (ART) regimen leads to the need for more expensive and less tolerable second line drugs. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Lower total fat intake leads to small but statistically significant and clinically meaningful, sustained reductions in body weight in adults in studies with baseline fat intakes of 28-43% of energy intake and durations from six months to over eight years. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Nearly 56% of the males and 68% of the females deaths were due to five leading causes (conditions arising during perinatal period, HIV/AIDS, tuberculosis, cardiovascular diseases and respiratory infections). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Reaching a target group not routinely served by national immunization programs previously with three doses of vaccine requires new delivery strategies, more transport of vaccines and health workers and more intensive IEC activities leading to new delivery costs for the immunization program that are greater than the costs incurred when a new infant vaccine is added to the existing infant immunization schedule. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Seamount-associated faunas are often considered highly endemic but isolation and diversification processes leading to such endemism have been poorly documented at those depths. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSIONS: These results indicate that loss of Cdk5 activity destabilizes junctional complexes containing E-cadherin, leading to internalization of E-cadherin and upregulation of N-cadherin. …”
Enlace del recurso
Enlace del recurso

“…BACKGROUND: The proximal chromosome 15q is prone to unequal crossover, leading to rearrangements. Although 15q11q13 duplications are common in patients with developmental delays and mental impairment, 15q aneusomies resulting in greater or equal to 4 copies of 15q11q13 are rare and no pentasomy 15q11q13 has been reported in the literature. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSION: These results point to AGT as independently conferring risk for various cardiovascular traits, and possibly interacting with these traits in events leading to atherosclerosis.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Tobacco smoking leads to death or disability and a drain on national resources. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Experimental breakthroughs, both in psychiatric aetiology and therapeutics, will come mainly from biology and its adjunct, psychopharmacology; while supplementary and complementary breakthroughs will come from the psychosocial, cognitive and behavioural approaches; the support base will come from phenomenology, epidemiology, nosology and diagnostics; while insights and leads can hopefully come from many fields, especially the psychosocial, the behavioural, the cognitive and the philosophical. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Rotavirus is a leading worldwide cause of acute gastroenteritis in young children. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…There was no evidence that planned home birth among low risk women leads to an increased risk of severe adverse maternal outcomes in a maternity care system with well trained midwives and a good referral and transportation system.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In Ohio, drug ODs surpassed MVCs as the leading cause of injury death in 2007. This trend has continued through the most current available data [3]. …”
Enlace del recurso

“…Diabetes is the ninth leading cause of death in women globally. In South Asians mortality in women with diabetes stands second highest. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso