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  1. 486921
    “…BACKGROUND: Pregnant women are at increased risk of complications in hepatitis E virus (HEV) infection, with the risk increasing as the pregnancy progresses, often leading to fulminant hepatic failure and adverse fetal outcome. …”
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    Clinical Profile, Maternal and Fetal Outcomes of Acute Hepatitis E in Pregnancy
  2. 486922
    “…BACKGROUND: HIV infection leads to a faster progression of liver disease in subjects infected with HCV, as compared with HCV mono-infected patients. …”
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    Sustained virological response to peginterferon therapy in patients infected with HCV (genotypes 2 and 3), with or without HIV
  3. 486923
    “…Infection with T. gondii is probably the leading cause of posterior uveitis in humans and the most comment route of transmission is raw and undercooked meat from infected animals. …”
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    Protective efficacy of Toxoplasma gondiicalcium-dependent protein kinase 1 (TgCDPK1) adjuvated with recombinant IL-15 and IL-21 against experimental toxoplasmosis in mice
  4. 486924
    “…Furthermore, donor-derived human mesenchymal stem cell (hMSC) expansion and fibrotic differentiation in the allograft results in bronchiolitis obliterans syndrome (BOS), a leading cause of post-LTx long-term mortality. Therefore, pretreatment of NHBD with recipient-specific bone-marrow-(BM)-derived hMSC might have the potential to both improve the postischemic allograft function and influence the long-term development of BOS by the numerous paracrine, immunomodulating and tissue-remodeling properties especially on type-II-pneumocytes of hMSC. …”
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    Mesenchymal stem cell pretreatment of non-heart-beating-donors in experimental lung transplantation
  5. 486925
    “…C(2)O(4)(2−) inhibits PSII activity, as well as the rate of RuBP regeneration and carboxylation efficiency, leading to the over production of reactive oxygen species (ROS). …”
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    Mechanisms by which the infection of Sclerotinia sclerotiorum (Lib.) de Bary affects the photosynthetic performance in tobacco leaves
  6. 486926
    “…INTRODUCTION: Cirrhosis secondary to HCV infection is expected to peak in the next decade, particularly in the HIV co-infected subgroup and has become a leading cause of morbidity among these individuals. …”
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    Risk of liver decompensation assessed in HIV/HCV co-infected individuals with advanced liver fibrosis: a faster countdown experience
  7. 486927
    “…The preferred simplification strategies are nuke-sparing regimens, mainly DRV/r-based monotherapy and dual therapy. ART switch leads to a complete resolution of toxicities in most cases in the short term.…”
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    Nuke-sparing regimens as a main simplification strategy and high level of toxicity resolution after antiretroviral switch: the SWITCHART Study
  8. 486928
    “…Sixteen (5%) patients had AEs leading to study drug discontinuation, most frequently rash (three patients), hypersensitivity and nausea (two patients each). …”
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    Phase IIIb, open-label single-arm trial of darunavir/cobicistat (DRV/COBI): Week 48 subgroup analysis of HIV-1-infected treatment-nave adults
  9. 486929
    “…If 1–4 windows are positive, the result is initially ‘unclear' and up to two further kits are submitted, further positivity leads to colonoscopy (‘weak positive'). If no further blood is detected, the test is deemed ‘normal' and subjects are tested again in 2 years' time. …”
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    Optimising faecal occult blood screening:retrospective analysis of NHS Bowel Cancer Screening data to improve the screening algorithm
  10. 486930
    “…In doing so, they continuously stimulate neurons leading ultimately to death of target invertebrates. …”
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    Systemic insecticides (neonicotinoids and fipronil): trends, uses, mode of action and metabolites
  11. 486931
    “…We found that some of the identified pathways have been implicated in cancers from literatures, while others have not been reported in the cancer before. The network analysis leads to the identification of significantly disrupted pathways and associated genes involved in the disease development. …”
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    Identification of genes and pathways involved in kidney renal clear cell carcinoma
  12. 486932
    “…BACKGROUND: Charcot-Marie-Tooth type 1A disease (CMT1A) is a rare orphan inherited neuropathy caused by an autosomal dominant duplication of a gene encoding for the structural myelin protein PMP22, which induces abnormal Schwann cell differentiation and dysmyelination, eventually leading to axonal suffering then loss and muscle wasting. …”
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    An exploratory randomised double-blind and placebo-controlled phase 2 study of a combination of baclofen, naltrexone and sorbitol (PXT3003) in patients with Charcot-Marie-Tooth disease type 1A
  13. 486933
    “…Background: Type II diabetes mellitus (DM) is one of the leading chronic diseases in Qatar as well as worldwide. …”
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    Prevention of type II diabetes mellitus in Qatar: Who is at risk?
  14. 486934
    “…Translatome analysis of mTOR downstream target genes established that differential inhibition of mTOR by EtOH and INK128 distinctly modulates translation of specific subsets of mRNAs involved in cell growth and survival, leading to differential cellular response and survival. …”
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    Distinct inhibitory effects on mTOR signaling by ethanol and INK128 in diffuse large B-cell lymphoma
  15. 486935
    “…RESULTS: In the first part of this study we found that stable miR-17 upregulation affects, like the CBF-AML fusion proteins (RUNX1-MTG8 or CBFB-MYH11), a core RUNX1-miRNA mechanism leading to KIT-induced proliferation of differentiation-arrested U937 myeloid cells. …”
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    miR-17 deregulates a core RUNX1-miRNA mechanism of CBF acute myeloid leukemia
  16. 486936
    “…BACKGROUND: Chronic diseases are the leading cause of death (63%) worldwide. A key behavioral risk factor is unhealthy eating. …”
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    Exploring Women’s Beliefs and Perceptions About Healthy Eating Blogs: A Qualitative Study
  17. 486937
    por Lakew, Yihunie, Haile, Demewoz
    Publicado 2015
    “…BACKGROUND: Tobacco is one of the leading preventable causes of non-communicable diseases. …”
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    Tobacco use and associated factors among adults in Ethiopia: further analysis of the 2011 Ethiopian Demographic and Health Survey
  18. 486938
    “…Dichotomizing a continuous biomarker measure to classify responders also leads to challenges. We present a case study of a prospective–retrospective approach for a continuous biomarker identified after patient enrollment but defined prospectively before the unblinding of data. …”
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    Clinical Translation and Validation of a Predictive Biomarker for Patritumab, an Anti-human Epidermal Growth Factor Receptor 3 (HER3) Monoclonal Antibody, in Patients With Advanced Non-small Cell Lung Cancer
  19. 486939
    “…INTRODUCTION: Cardiovascular diseases (CVD) are the leading death cause in modern world and are the most public health problem. …”
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    Qualitative Evaluation of Cardiovascular Diseases Management in Family Medicine Team in One Year Level
  20. 486940
    “…Transcriptome analyses of select pathways, from generation of pyruvate and leading up to TAG accumulation, in mesocarp tissues of avocado was conducted and compared with that of oil-rich monocot (oil palm) and dicot (rapeseed and castor) tissues to identify tissue- and species-specific regulation and biosynthesis of TAG in plants. …”
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    Oil biosynthesis in a basal angiosperm: transcriptome analysis of Persea Americana mesocarp
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