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  1. 486941
    “…BACKGROUND: Cancer is the leading cause of death in older dogs and its prevalence is increasing. …”
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    Activity of the DNA minor groove cross-linking agent SG2000 (SJG-136) against canine tumours
  2. 486942
    “…BACKGROUND: Homicide is one of the leading causes of mortality in the World. Homicide risk factors vary significantly between countries and regions. …”
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    Risk factors for homicide victimization in post-genocide Rwanda: a population -based case- control study
  3. 486943
    “…BACKGROUND: Previous studies found that the facet joint of the C1 vertebra were removed (C1 facetectomy) before extirpation from the extramedullary tumor in craniocervical junction, leading to postoperative upper cervical instability or deformity. …”
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    Occipito-cervical fusion following gross total resection for the treatment of spinal extramedullary tumors in craniocervical junction: a retrospective case series
  4. 486944
    “…In UCL injury with a residual ossicle of the ligament-bone junction, repeating sharp pain and remission readily leads to tear of the medial support structure and poor performance. …”
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    What are the Risk Factors for Failure after Conservative Treatment of Ulnar Collateral Ligament Injuries of the Elbow in Baseball Players?
  5. 486945
    “…This, in turn, may increases forces on the posterior soft tissues of the glenohumeral joint leading to the development of GIRD. Given that deficits in total arc of motion and internal rotation are associated with increased arm injury risk future studies should examine the amount of humeral torsion that predisposes a shoulder to develop GIRD.…”
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    Professional Pitchers with GIRD Display Greater Dominant Humeral Retrotorsion than Pitchers with Normal ROM
  6. 486946
    “…MP is usually asymptomatic but, when it is large and its free edge impinges on the superior anteromedial and medial portion of the medial femoral condyle, it might cause chondral damage leading to full thickness cartilage lesions. When it becomes symptomatic, chondral damage quite often is already advanced. …”
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    How Does Delayed Excision of Symptomatic Medial Plica Affect the Outcomes?
  7. 486947
    “…BACKGROUND: Duchenne muscular dystrophy (DMD) is the most common inherited muscle disease, leading to severe disability and death in young men. …”
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    P2RX7 Purinoceptor: A Therapeutic Target for Ameliorating the Symptoms of Duchenne Muscular Dystrophy
  8. 486948
    “…The gout-associated allele of IL1B increases expression of IL-1β – the multiplicative interaction with CARD8 would be consistent with a synergy of greater inflammasome activity (resulting from reduced CARD8) combined with higher levels of pre-IL-1β expression leading to increased production of mature IL-1β in gout. …”
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    Multiplicative interaction of functional inflammasome genetic variants in determining the risk of gout
  9. 486949
    “…We hypothesize that canonical Wnt pathway plays a role in the retinal lesion of age-related macular degeneration (AMD), a leading cause of irreversible central visual loss in elderly. …”
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    Wnt signaling in age-related macular degeneration: human macular tissue and mouse model
  10. 486950
    “…BACKGROUND: Although the incidence of acute death related to coronary artery disease has decreased with the advent of new interventional therapies, myocardial infarction remains one of the leading causes of death in the US. Current animal models developed to replicate this phenomenon have been associated with unacceptably high morbidity and mortality. …”
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    Embolization of the first diagonal branch of the left anterior descending coronary artery as a porcine model of chronic trans-mural myocardial infarction
  11. 486951
    “…Although augmenting BMP7 signaling in GSC by exogenous BMP7 treatment did not effectively stop GSC growth, it markedly sensitized both GSC-500 μM TMZ and GSC-parental to 35 μM TMZ treatment, leading to loss of self-renewal and migration capacity. …”
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    Bone morphogenetic protein 7 sensitizes O6-methylguanine methyltransferase expressing-glioblastoma stem cells to clinically relevant dose of temozolomide
  12. 486952
    “…BACKGROUND: Pneumonia is the leading cause of child mortality under five years of age worldwide. …”
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    A randomized controlled trial of hospital versus home based therapy with oral amoxicillin for severe pneumonia in children aged 3 – 59 months: The IndiaCLEN Severe Pneumonia Oral Therapy (ISPOT) Study
  13. 486953
    “…RESULTS: During the fruit development of ‘Mochizuki’ and ‘Akatsuki’, anthocyanin accumulation was observed only in the skin of red ‘Akatsuki’ fruit in the late ripening stages concomitant with high mRNA levels of the last step gene leading to anthocyanin accumulation, UDP-glucose:flavonoid-3-O-glucosyltransferase (UFGT). …”
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    The crucial role of PpMYB10.1 in anthocyanin accumulation in peach and relationships between its allelic type and skin color phenotype
  14. 486954
    “…There is an urgent need to further address risk factors leading to super-obesity among pregnant women and for maternity services to better address pre-pregnancy and pregnancy care to reduce associated inequalities in perinatal outcomes.…”
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    Maternal super-obesity and perinatal outcomes in Australia: a national population-based cohort study
  15. 486955
    “…We estimate that 29% (95% UI 23–36%) of cases caused by diseases in our study, or 582 million (95% UI 401–922 million), were transmitted by contaminated food, resulting in 25.2 million (95% UI 17.5–37.0 million) DALYs. Norovirus was the leading cause of foodborne illness causing 125 million (95% UI 70–251 million) cases, while Campylobacter spp. caused 96 million (95% UI 52–177 million) foodborne illnesses. …”
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    World Health Organization Estimates of the Global and Regional Disease Burden of 22 Foodborne Bacterial, Protozoal, and Viral Diseases, 2010: A Data Synthesis
  16. 486956
    “…It has been shown that intensive and personalized cognitive rehabilitation (CR), based on working memory exercises, leads to improved cognitive status of healthy and cognitive-impaired subjects. …”
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    A New App for At-Home Cognitive Training: Description and Pilot Testing on Patients with Multiple Sclerosis
  17. 486957
    “…In the mouse brain, miR-146a, and miR-221 display strong neuronal expression in regions important for high cognitive functions, and we demonstrated that reproducing abnormal miR-146a expression in mouse primary cell cultures leads to impaired neuronal dendritic arborization and increased astrocyte glutamate uptake capacities. …”
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    Profiling olfactory stem cells from living patients identifies miRNAs relevant for autism pathophysiology
  18. 486958
    por Li, Yuan
    Publicado 2015
    “…An inadequate Gn dose is not capable to stimulate multiple follicles development, resulting in cycle cancellation, while excessive ovarian stimulation in these patients commonly leading to a certain degree of OHSS. A low starting dose of Gn, 37.5 IU, is recommended by the consensus on PCOS infertility treatment endorsed by both the European Society for Human Reproduction and Embryology and the American Society for Reproductive Medicine. …”
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    AB076. Standardization and individualization in controlled ovarian stimulation
  19. 486959
    “…In Brazil, breast cancer is the most frequently diagnosed tumor and the leading cause of cancer death in women. Hereditary cancer represents approximately 5 to 10 % of BC cases. …”
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    Association of polymorphisms with a family history of cancer and the presence of germline mutations in the BRCA1/BRCA2 genes
  20. 486960
    “…Merely reading a guideline rarely leads to implementation of recommendations. The American Academy of Neurology (AAN) has a formal process of guideline development and dissemination. …”
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    The Impact of Social Media on Dissemination and Implementation of Clinical Practice Guidelines: A Longitudinal Observational Study
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