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  1. 487001
    “…BACKGROUND: Osteoarthritis (OA) is a leading cause of disability in developed nations. …”
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    Using discrete choice experiments as a decision aid in total knee arthroplasty: study protocol for a randomised controlled trial
  2. 487002
    “…Patients with major trauma are prone to homeostasis leading to inflammatory response syndrome and multiple organ distress syndrome. …”
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    The Relation Between Reflex Sympathetic Dystrophy Syndrome and Trauma Severity in Patients With Distal Tibia Fracture
  3. 487003
    “…TRIAL REGISTRATION: This study was registered prospectively in the NCT Clinical Trials Registry (ClinicalTrials.gov) under NCT01020630 on November 23, 2009 after approval by the leading ethics committee of the Medical Association of Rhineland-Palatinate, Mainz, in coordination with the participating ethics committees (see Additional file 2) on September 16, 2009. …”
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    Sunitinib added to FOLFIRI versus FOLFIRI in patients with chemorefractory advanced adenocarcinoma of the stomach or lower esophagus: a randomized, placebo-controlled phase II AIO trial with serum biomarker program
  4. 487004
    “…The perception that services are distant or deficient leads to lower enrolments. The second insight is that trust in the scheme enables enrolment. …”
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    What Factors Affect Voluntary Uptake of Community-Based Health Insurance Schemes in Low- and Middle-Income Countries? A Systematic Review and Meta-Analysis
  5. 487005
    “…In kidneys of hydrallantois-affected fetuses, the mutation in SLC12A1 impaired the apical membrane localization of SLC12A1 and reabsorption of Na(+)-K(+)-2Cl(−) in the thick ascending limb of the loop of Henle, leading to a defect in the concentration of urine via the countercurrent mechanism. …”
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    A missense mutation in solute carrier family 12, member 1 (SLC12A1) causes hydrallantois in Japanese Black cattle
  6. 487006
    “…Sarcomere shortening in active contraction leads to change of ventricular zero-stress configurations during the cardiac cycle. …”
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    Patient-Specific MRI-Based Right Ventricle Models Using Different Zero-Load Diastole and Systole Geometries for Better Cardiac Stress and Strain Calculations and Pulmonary Valve Replacement Surgical Outcome Predictions
  7. 487007
    “…BACKGROUND: Chronic diseases, like diabetes mellitus, heart disease and cancer are leading causes of death and disability. These conditions are at least partially preventable or modifiable, e.g. by enhancing patients’ self-management. …”
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    Effectiveness of Telephone-Based Health Coaching for Patients with Chronic Conditions: A Randomised Controlled Trial
  8. 487008
    “…BACKGROUND: Type 2 diabetes (T2DM) is the leading cause of chronic kidney disease (CKD) in western countries. …”
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    Blood pressure and proteinuria control remains a challenge in patients with type 2 diabetes mellitus and chronic kidney disease: experience from the prospective observational ALICE-PROTECT study
  9. 487009
    “…Human caliciviruses (HuCV) including norovirus (NoV, genogroup GI and GII) and sapovirus (SaV), is a leading cause of acute sporadic diarrhea in individuals across all age groups. …”
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    Emergence of human caliciviruses among diarrhea cases in southwest China
  10. 487010
    “…DISCUSSION: Even short-term treatment with metformin causes a decrease in serum Cbl folic acid and increase in Hcy, which leads to peripheral neuropathy in Type 2 diabetes patients. …”
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    Study of Vitamin B(12) deficiency and peripheral neuropathy in metformin-treated early Type 2 diabetes mellitus
  11. 487011
    por Zhang, Xiujun, Qu, Yinbo, Qin, Yuqi
    Publicado 2016
    “…BACKGROUND: Heterochromatin protein 1 (HP1, homologue HepA in Penicillium oxalicum) binding is associated with a highly compact chromatin state accompanied by gene silencing or repression. HP1 loss leads to the derepression of gene expression. We investigated HepA roles in regulating cellulolytic enzyme gene expression, as an increasingly number of studies have suggested that cellulolytic enzyme gene expression is not only regulated by transcription factors, but is also affected by the chromatin status. …”
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    Expression and chromatin structures of cellulolytic enzyme gene regulated by heterochromatin protein 1
  12. 487012
    “…BACKGROUND: Coronary artery bypass graft (CABG) surgery with cardiopulmonary bypass (CPB) triggers an inflammatory reaction, leading to the development of myocardial damage and dysfunction. …”
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    Effects of Low-dose Selenium on the Inflammatory Response in Coronary Artery Bypass Graft Surgery: A Clinical Trial
  13. 487013
    “…BACKGROUND: Cancer is one of the leading cause of mortality. Even though efficient drugs are being produced to treat cancer, conventional medicines are costly and have adverse effects. …”
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    Rice callus suspension culture inhibits growth of cell lines of multiple cancer types and induces apoptosis in lung cancer cell line
  14. 487014
    “…BACKGROUND: Chronic obstructive pulmonary disease (COPD) is the third-leading cause of death worldwide. Identifying COPD-associated DNA methylation marks in African-Americans may contribute to our understanding of racial disparities in COPD susceptibility. …”
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    Differential DNA methylation marks and gene comethylation of COPD in African-Americans with COPD exacerbations
  15. 487015
    “…CONCLUSION: These results strengthen the idea of tumor immune escape variants leading to metastasis. Moreover, SCC tumors showing downregulation of HLA-A or total classical HLA in combination with HLA-G expression had poor prognosis. …”
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    Classical and non-classical HLA class I aberrations in primary cervical squamous- and adenocarcinomas and paired lymph node metastases
  16. 487016
    “…Pharmacological agents suppressed the phosphorylation of JAK2-STAT3 and MAPKs, leading to the amelioration of the phagocytic ability of EMF-stimulated N9 cells. …”
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    Inhibition of STAT3- and MAPK-dependent PGE(2) synthesis ameliorates phagocytosis of fibrillar β-amyloid peptide (1-42) via EP2 receptor in EMF-stimulated N9 microglial cells
  17. 487017
    por Chen, Elizabeth, Mangone, Emily Rose
    Publicado 2016
    “…BACKGROUND: Adolescents in the United States and globally represent a high-risk population for unintended pregnancy, which leads to high social, economic, and health costs. …”
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    A Systematic Review of Apps using Mobile Criteria for Adolescent Pregnancy Prevention (mCAPP)
  18. 487018
    “…BACKGROUND: Preterm birth (PTB) is the leading cause of perinatal morbidity and mortality worldwide, and its prevention is an important health-care priority. …”
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    Role of Cervical Cerclage and Vaginal Progesterone in the Treatment of Cervical Incompetence with/without Preterm Birth History
  19. 487019
    por Gonzalez-Block, Miguel A
    Publicado 2004
    “…These dimensions can vary in their degree of coordination, leading to a complementary or a fragmented research portfolio. …”
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    Health policy and systems research agendas in developing countries
  20. 487020
    “…An alternative and promising approach to reducing inpatient falls is through the modification of the hospital physical environment and the night lighting of hospital wards is a leading candidate for investigation. In this pilot trial, we will determine the feasibility of conducting a main trial to evaluate the effects of modified night lighting on inpatient ward level fall rates. …”
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    Feasibility of a stepped wedge cluster RCT and concurrent observational sub-study to evaluate the effects of modified ward night lighting on inpatient fall rates and sleep quality: a protocol for a pilot trial
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