“…Serum PSA levels increase in both PCa and benign prostatic hyperplasia, leading to an increased number of unnecessary biopsies. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Hepatitis B virus (HBV) infection causes acute and chronic liver disease, ultimately leading to the development of liver cirrhosis (LC) and hepatocellular carcinoma (HCC). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: Our method greatly outperforms existing methods and leads to much more accurate contact-assisted folding. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The ERG’s critical assessment of the company’s economic evaluation highlighted a number of concerns, including (a) not using the intention-to-treat (ITT) population; (b) inconsistencies in estimating prediction equations; (c) not fully incorporating the impact of adverse events; (d) incorrectly incorporating the new patient access scheme (PAS); and (e) the assumption that AA non-compliance leads to recoverable drug costs. Although some of these issues were adjusted in the ERG base case, the ERG could not estimate the impact of all of these issues, and thus acknowledges that there are still uncertainties concerning the cost-effectiveness evidence. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Gastric cancer (GC) is the second leading cause of cancer death in China. It is well known that Cixian in Hebei Province is one of the highest risk areas of GC in China and worldwide. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Patients with atrial fibrillation who undergo intracoronary stenting traditionally are treated with a vitamin K antagonist (VKA) plus dual antiplatelet therapy (DAPT), yet this treatment leads to high risks of bleeding. We hypothesized that a regimen of rivaroxaban plus a P2Y(12) inhibitor monotherapy or rivaroxaban plus DAPT could reduce bleeding and thereby have a favorable impact on all-cause mortality and the need for rehospitalization. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…CONCLUSION: The results of this study suggest that Z. leprieurii is active on resistant strains of M. tuberculosis and could be a potential source of new leads against resistant tuberculosis. It also verifies the local use of the plant in treatment of tuberculosis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…METHODS: A total of 226 consecutive patients with non-ischemic cardiomyopathy were assessed for fQRS on surface ECG as defined by presence of an additional R wave (R prime), notching in nadir of the S wave, notching of R wave, or the presence of more than one R prime (fragmentation) in two contiguous leads corresponding to a major myocardial segment. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Alzheimer’s disease (AD)-linked protein, presenilin 1 (PS1), is present at the synapse, and the knock-out of presenilin in mice leads to synaptic dysfunction. On the other hand, synaptic activity was shown to influence PS1-dependent generation of distinct amyloid β (Aβ) species. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In the present study, the blockade of the Fe-NTA promoted EGFR signaling and sustained ERK activity with β-sitosterol leads to impede tumor promotion and maintenance. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…However, it remains unclear the mechanism by which Helicobacter infection leads to gastric cancer. Furthermore, the underlying molecular events involved during the progression of Helicobacter infection to gastric malignancy are not well understood. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Two participants experienced asymptomatic ≥grade 3 transaminitis leading to discontinuation of vaccinations, and three had grade 3 solicited local or systemic reactions. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Several pro-inflammatory cytokines, mainly derived from Th1 and Th17 lymphocytes, seem to be involved in different pathogenic pathways leading to development of the clinical manifestations. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Non-AIDS-defining cancers are currently the leading non-HIV/AIDS-related cause of death in both HIV-infected and uninfected individuals. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Chronic liver scarring from any cause leads to cirrhosis, portal hypertension, and a progressive decline in renal blood flow and renal function. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…OBJECTIVES: This study aimed to examine the associations between cumulative environmental quality and all-cause and leading cause-specific (heart disease, cancer, and stroke) mortality rates. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Public health facilities were the leading source of care in comparison areas, providing care to 86.1% (95% CI 79.0–93.3) of children with fever taken for care outside the home. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Putative promoters in the intergenic regions upstream the kstD1, kstD2 and kstD3 genes were identified and probed in an apramycin-promoter-test vector, leading to the functional evidence of those R. ruber kstD promoters. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Snakebite-related acute kidney injury (AKI) is a common community-acquired AKI in tropical countries leading to death and disability. The aims of this study were to (1) determine the occurrence of snakebite-related AKI, (2) assess factors at presentation that are associated with snakebite-related AKI, and (3) determine the outcomes of patients with snakebite-related AKI. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: As adults age, their physical activity decreases and sedentary behavior increases, leading to increased risk of negative health outcomes. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso