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  1. 487081
    “…These results suggested that Kir2.1 and Nav1.5 channels closely interact with each other leading to the formation of a pool of complexed channels whose biology is similar to that of the Nav1.5 channels.…”
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    Kir2.1-Nav1.5 Channel Complexes Are Differently Regulated than Kir2.1 and Nav1.5 Channels Alone
  2. 487082
    “…BACKGROUND: Shigella infections are a leading cause of diarrhoeal death among children in low-income and middle-income countries. …”
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    Identification and management of Shigella infection in children with diarrhoea: a systematic review and meta-analysis
  3. 487083
    “…By functional enrichment analysis, genes likely to be involved in biosynthetic pathways leading to floral scent production, such as 1-deoxy-D-xylulose-5-phosphate synthase (DXS), 3-ketoacyl-CoA thiolase (KAT), hydroperoxide lyase (HPL), geranylgeranyl pyrophosphate (GGPP) 4-hydroxy-3-methylbut-2-en-1-yl diphosphate (HDS) and terpene synthase (TPS), and floral color genes, such as dihydroflavonol 4-reductase (DFR), chalcone synthase (CHS), chalcone isomerase (CHI), flavonol synthase (FLS) were identified. …”
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    Identification of differentially expressed genes in flower, leaf and bulb scale of Lilium oriental hybrid ‘Sorbonne’ and putative control network for scent genes
  4. 487084
    “…These effects were expected to translate into better individual acceptance of the intervention and hence high Treatment Coverage, leading to a sustainable community-led strategy and reduction in the disease burden. …”
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    Programmatic factors associated with the limited impact of Community-Directed Treatment with Ivermectin to control Onchocerciasis in three drainage basins of South West Cameroon
  5. 487085
    “…In addition, the cytoskeleton F-actin network within CD34(+) cells was organized more significantly at the leading edge of the adherent cells on the moderately stiff (42 kPa) or stiff (72 kPa) substrates as compared with those on the soft (4 kPa and 15 kPa) substrates. …”
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    Bone marrow CD34(+) cell subset under induction of moderate stiffness of extracellular matrix after myocardial infarction facilitated endothelial lineage commitment in vitro
  6. 487086
    “…BACKGROUND: The aging process leads to a potential decline in immune function and adversely affects the gut microbiota. …”
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    Effects of Soluble Corn Fiber Alone or in Synbiotic Combination with Lactobacillus rhamnosus GG and the Pilus-Deficient Derivative GG-PB12 on Fecal Microbiota, Metabolism, and Markers of Immune Function: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study in Healthy Elderly (Saimes Study)
  7. 487087
    “…The aims of this study are to (1) investigate whether a single inhaled N(2)O administration leads to antidepressant effects in adolescents with depression at 24 h, (2) determine whether combined N(2)O and SSRI administration (commenced after N(2)O intervention) provides a clinically significant improvement in mood over and above the benefits from SSRI administration alone, and, (3) investigate whether the effect seen following N(2)O administration can be used as a predictor of SSRI treatment response. …”
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    Nitrous oxide (N(2)O) and subsequent open-label SSRI treatment of adolescents with depression (NOTAD): study protocol for a randomised controlled trial
  8. 487088
    “…RESULTS: Age ranged from 17.6 to 98.5 years with medians of 70.1 and 69.9 years for males and females respectively: 7% were <35 years of age, with the majority (63%) >65 years old. The leading renal diagnoses changed from genetic real disease (GRD) and glomerulonephritis (GN) in the younger patients to renovascular disease (RVD) and hypertension (HTN) in older patients. …”
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    Spectrum (characteristics) of patients with chronic kidney disease (CKD) with increasing age in a major metropolitan renal service
  9. 487089
    “…Pregnant women with no formal education, incomplete primary education, primary education and secondary education were most likely to practice self-medication than pregnant women with college or university education (P < 0.01, OR = 6.37 95% CI 2.37–19.03, P < 0.01, OR = 6.58, 95% CI 2.36–18.25, P < 0.01, OR = 3.78, 95% CI 1.89–7.56, P < 0.01, OR = 2.59 95% CI = 1.30–5.17). The leading illness/symptoms which led to self-medication among pregnant women attending clinic were malaria 56 (32.56%, morning sickness 44 (25.55%) and headache 33(19.19%). …”
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    Self-medication among pregnant women attending antenatal clinic at Makongoro health centre in Mwanza, Tanzania: a challenge to health systems
  10. 487090
    “…Analysis based on decision trees showed that the IFNγ levels produced in response to Rv2029c was the leading variable that best-classified disease status. …”
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    Potential of DosR and Rpf antigens from Mycobacterium tuberculosis to discriminate between latent and active tuberculosis in a tuberculosis endemic population of Medellin Colombia
  11. 487091
    “…In other words, anemia is the most common extraintestinal complication. This leads to reduced quality of life, reduce the time wasted at work and frequent admissions. …”
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    55: EVALUATING THE PREVALENCE OF ANEMIA AND ASSOCIATED FACTORS IN PATIENTS WITH ULCERATIVE COLITIS
  12. 487092
    “…BACKGROUND: Lung cancer is the leading cause of cancer-related mortality in Utah despite having the nation’s lowest smoking rate. …”
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    A statewide investigation of geographic lung cancer incidence patterns and radon exposure in a low-smoking population
  13. 487093
    “…BACKGROUND: Diarrhea is the leading infectious cause of childhood morbidity and mortality. …”
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    Characteristics of diarrheagenic Escherichia coli among children under 5 years of age with acute diarrhea: a hospital based study
  14. 487094
    “…It is not known how frequently genetic susceptibility to type 1 diabetes leads to a diagnosis of diabetes after age 30 years. …”
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    Frequency and phenotype of type 1 diabetes in the first six decades of life: a cross-sectional, genetically stratified survival analysis from UK Biobank
  15. 487095
    “…INTRODUCTION: HIV‐1 infection leads to chronic inflammation and to an increased risk of non‐AIDS mortality. …”
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    Increased non‐AIDS mortality among persons with AIDS‐defining events after antiretroviral therapy initiation
  16. 487096
    “…Furthermore, HOXB3 induced DNA methyltransferase 3B (DNMT3B) expression to bind in the pre-miR-375 promoter and enhanced DNA hypermethylation of pre-miR-375, leading to the lower expression of miR-375. CONCLUSIONS: Collectively, we have identified a miR-375-HOXB3-CDCA3/DNMT3B regulatory circuitry which contributes to leukemogenesis and suggests a therapeutic strategy of restoring miR-375 expression in AML. …”
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    A novel miR-375-HOXB3-CDCA3/DNMT3B regulatory circuitry contributes to leukemogenesis in acute myeloid leukemia
  17. 487097
    “…BACKGROUND: Norovirus (NoV), a member of the Caliciviridae, is now recognized as the leading cause of acute gastroenteritis (AGE) worldwide. …”
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    Molecular epidemiology of genogroup II norovirus infections in acute gastroenteritis patients during 2014–2016 in Pudong New Area, Shanghai, China
  18. 487098
    “…PROBLEM/CONDITION: Motor-vehicle crashes are a leading cause of death in the United States. Compared with urban residents, rural residents are at an increased risk for death from crashes and are less likely to wear seat belts. …”
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    Rural and Urban Differences in Passenger-Vehicle–Occupant Deaths and Seat Belt Use Among Adults — United States, 2014
  19. 487099
    “…BACKGROUND: Lung cancer is the leading cause of cancer-related deaths in the United States. …”
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    Implementation of Digital Awareness Strategies to Engage Patients and Providers in a Lung Cancer Screening Program: Retrospective Study
  20. 487100
    “…BACKGROUND: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects the motor neuromuscular system leading to complete paralysis and premature death. …”
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    RNS60 exerts therapeutic effects in the SOD1 ALS mouse model through protective glia and peripheral nerve rescue
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