“…BACKGROUND: Malaria in pregnancy leads to serious adverse effects on the mother and the child and accounts for 75,000–200,000 infant deaths every year. …”
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“…The activation of the TGF-β1/Smad2 and Smad3/Stat3 signaling pathways leading to airway fibrosis was more profoundly induced by F1. …”
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“…Clonorchiasis as a neglected tropical zoonosis, leads to serious economic and public health burden in China. …”
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“…Activation of G(s)-coupled receptors stimulate adenylyl cyclase leading to cyclic AMP (cAMP) production, which is known to induce mucus overproduction through the cAMP response element binding protein (CREB) in airway epithelial cells. …”
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“…IMPORTANCE: Educational attainment is the leading social determinant of health, but few studies of prevention programs have examined whether the programs are associated with educational attainment outcomes after the mid-20s, especially for large-scale programs that provide a longer duration of services. …”
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“…METHODS: A 38-year old man suffered severe psychotic episodes at age 19, leading to a diagnosis of treatment-resistant schizophrenia. …”
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“…BACKGROUND: Neurocognitive phenotypes may contribute to understanding the pathway leading from genes to psychopathology. We aimed to investigate associations of intelligence, processing speed and verbal working memory between parents and offspring in families with schizophrenia, bipolar disorder and controls. …”
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“…This will be the world first RCT of a Quitline intervention delivered to people with SMI that also includes a concurrent economic evaluation. As smoking is the leading cause of preventable death in people with SMI, if Quitlink is shown to be effective, it has the potential to greatly improve individuals’ longevity, quality of life, mental health and reduce health care costs. …”
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“…An in-frame deletion in hDAT at N336 (∆N336) leads to abnormal DA homeostasis. He demonstrated these dysfunctions in brains of Drosophila melanogaster expressing hDAT ∆N336. …”
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“…RESULTS: We identified a total of 2,774 cases over 12.94 million person-years at risk, leading to a crude incidence of 21.4 per 100,000 person-years (95%CI: 19.4–23.4). …”
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“…DISCUSSION: These results indicate that within the right prefrontal cortex, STPS+/- patients may undergo different cortical maturation trajectories leading up to and through a first episode of psychosis. …”
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“…BACKGROUND: In patients with schizophrenia, antipsychotic medications, including second-generation antipsychotics, may cause many side-effects (SE) often leading to treatment discontinuation, and possible relapse as a consequence. …”
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“…Further, schizophrenia, either in itself or through the use of antipsychotics, may interact with cannabis in various organs, potentially leading to different associations. For these reasons, we aimed to investigate the associations between cannabis and later development of disorders of the digestive organs, both in patients with schizophrenia and in healthy controls. …”
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“…BACKGROUND: Physical inactivity is the fourth leading cause of death worldwide, costing approximately US $67.5 billion per year to health care systems. …”
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“…BACKGROUND: Diabetes mellitus (DM) is a metabolic disorder that occurs as a result of absolute or relative insufficiency of insulin release and/or insulin effect due to impairment of carbohydrate, fat and protein metabolism, and it is characterized by hyperglycemia and leads to various complications. OBJECTIVE: In this study, it was aimed to investigate the effects of hesperidin (HP) and quercetin, which are natural flavonoids, on serum malondialdehyde (MDA), glutathione (GSH), tumor necrosis factor alpha (TNF-α), and interleukin-6 (IL-6) levels in rats with streptozotocin (STZ)-induced diabetes. …”
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“…The nNOS was shown to play critical roles in a variety of muscle functions and alterations of its expression and location in dystrophic muscle fiber leads to an increase of the muscle fatigability. …”
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“…More deaths could be prevented, especially in CIS countries, through intervention and prevention efforts focusing on the leading causes of death, which are road injuries, drowning, and lower respiratory infections. …”
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“…BACKGROUND: Gastric cancer is currently the fourth leading cause of cancer-related death worldwide. Gastric cancer is often diagnosed at advanced stages and the outcome of the treatment is often poor. …”
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“…BACKGROUND: Cigarette smoking is the leading preventable cause of death and is responsible for more than 480,000 deaths per year in the United States. …”
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“…However, there is evidence that PAAS is often not detected by CMR, implying a significant sensitivity problem, and imaging parameters vary between leading centres. Therefore, there is a need to establish the optimal imaging parameters to detect PAAS. …”
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