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  1. 487201
    “…Background: Primary hyperparathyroidism is a relatively common disorder caused by the inappropriate autonomous secretion of parathyroid hormone which subsequently leads to hypercalcemia. There is increased prevalence of vitamin D deficiency in patients with primary hyperparathyroidism. …”
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  2. 487202
    “…Early recognition of MEN1 associated tumors through periodic biochemical and radiological surveillance allows for early intervention, leading to presumed reduction in morbidity and premature death related to metabolic effects and tumor metastases. …”
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  3. 487203
    por Lim, Jayoung, Lim, Dong Jun
    Publicado 2019
    “…Hypocalcemia is a potentially life-threatening biochemical disorder that cause papilledema leading to the loss of vision. Therefore we should be aware of importance of monitoring calcium levels and renal function before and during denosumab therapy. …”
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  4. 487204
    “…The increased expression of the aromatase enzyme in the adipose tissue of obese men leads to a high conversion of androgens to estrogen, exerting a negative feedback on the hypothalamus-pituitary-gonadal axis contributing to hypogonadotropic hypogonadism. …”
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  5. 487205
    “…In cases where eucortisolemia is achieved by pharmacologic therapy preoperatively, the corticotrope cells can recover their function leading to detectable postoperative cortisol levels not always indicative of unsuccessful tumor resection. …”
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  6. 487206
    “…This is the first report of adrenal ablation by radiosurgery in this setting, leading to cure of CD.…”
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  7. 487207
    “…Introduction Adrenocorticotropic hormone (ACTH) overproduction leads to hypercortisolism and Cushing syndrome (CS). …”
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  8. 487208
    “…Background Hypothalamic amenorrhoea (HA) is a condition characterised by reduced GnRH pulsatility as a result of low body weight, excessive exercise, or psychological stress. HA leads to anovulatory infertility and osteoporosis. …”
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  9. 487209
    “…However, successful cannulation of the right adrenal vein (R-AV) is difficult and leads to failed AVS in some cases. Even in successful AVS, results are sometimes discordant with other clinical findings. …”
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  10. 487210
    por Gottesman, Bethany, Marinkovic, Maja
    Publicado 2019
    “…Background: Aromatase deficiency (AD) is a rare autosomal recessive genetic disorder caused by loss of function mutation in CYP19A1 leading to normal androgen but low estrogen levels. …”
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  11. 487211
    “…Background: NCCAH is characterized by reduced 21-hydroxylase activity leading to elevations in adrenal androgens. It may be associated with an inadequate cortisol response to ACTH stimulation. …”
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  12. 487212
  13. 487213
    “…Genetic testing showed a heterozygous germline mutation in the MEN1 gene, c.219_220delCG (frameshift leading to premature protein truncation). She had no family history consistent with MEN1. …”
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  14. 487214
    “…After administration of 200 mcg of thyrotropin releasing hormone (TRH) intravenously, exaggerated TSH response was noted, with TSH levels showing 6.0, 24.7, 22.6, and 14.7 μIU/mL at 0, 20, 30, and 60 minutes, respectively, leading to the diagnosis of RTH. DNA sequencing of exons 4-10 of thyroid hormone receptor β gene revealed no mutation. …”
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  15. 487215
    “…Studies have found T3-treatment significantly attenuated experimental lung injury and further, T3-treatment has been shown to antagonize well known mediators of fibrosis including TGFB-1, leading to less collagen deposition in liver and skin fibrosis [2, 3]. …”
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  16. 487216
    “…This decrease in estrogens leads to changes in metabolic phenotype, increasing the risk of weight gain from fat, metabolic syndrome, and type 2 diabetes in postmenopausal women. …”
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  17. 487217
    “…Head CT showed no acute pathology however, revealed extensive bilateral calcifications of the dentate nuclei, basal ganglia, thalami and white matter, leading to consideration of FS. Calcium rose above 8 mg/dl with treatment (calcium gluconate infusion; oral calcium acetate and calcitriol via nasogastric tube). …”
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  18. 487218
    “…They can also provide key information about how rare diseases develop and progress, leading to development of disease models that help make drug development more efficient and advancing the understanding of rare endocrine tumors. …”
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  19. 487219
    “…He had significant cervical and thoracolumbar scoliosis due to muscle atrophy leading to contractures. MRI revealed basal ganglia calcifications. …”
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  20. 487220
    por Azova, Svetlana, Wolfsdorf, Joseph
    Publicado 2019
    “…Background: Unintentional exposure to cutaneous androgen products leading to virilization has previously been described in children, however, continues to be an overlooked cause of precocious sexual development. …”
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