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  1. 487241
    “…IMPORTANCE: A growing body of literature suggests that having a strong sense of purpose in life leads to improvements in both physical and mental health and enhances overall quality of life. …”
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    Association Between Life Purpose and Mortality Among US Adults Older Than 50 Years
  2. 487242
    “…Patients with two mutations leading to premature protein termination had a WWS phenotype, while the presence of at least one missense mutation was associated with milder phenotypes. …”
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    Clinical long-time course, novel mutations and genotype-phenotype correlation in a cohort of 27 families with POMT1-related disorders
  3. 487243
    “…IMPORTANCE: As the overall prevalence of prenatal cannabis use rises, it is vital to also monitor trends in the frequency of cannabis use in the period leading up to and during pregnancy because more frequent use may confer greater health risks for mothers and their children. …”
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    Self-reported Daily, Weekly, and Monthly Cannabis Use Among Women Before and During Pregnancy
  4. 487244
    “…CONCLUSIONS: Our results confirm the benefit of array-CGH in the current clinical genetic diagnostics leading to identification of the genetic cause of ID/DD in affected children. …”
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    The clinical benefit of array-based comparative genomic hybridization for detection of copy number variants in Czech children with intellectual disability and developmental delay
  5. 487245
    “…Knowledge of sex-related differences can enhance our understanding in molecular and developmental processes leading to unisexual flower development. Coccinia grandis is a dioecious species belonging to Cucurbitaceae, a family well-known for diverse sexual forms. …”
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    Flower bud proteome reveals modulation of sex-biased proteins potentially associated with sex expression and modification in dioecious Coccinia grandis
  6. 487246
    “…Despite the prevalence of the procedure, stigma surrounding abortion in Canada leads to barriers for women to access this service. …”
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    Feasibility and Acceptability of a Mobile Technology Intervention to Support Postabortion Care in British Columbia: Phase I
  7. 487247
    por Tarver, Will L, Haggstrom, David A
    Publicado 2019
    “…A majority of studies used eHealth technologies (n=41) finding them to be leading sources of cancer-related health information and significantly improving outcomes such as screening among nonadherent individuals and increasing knowledge about cancer and cancer screening. …”
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    The Use of Cancer-Specific Patient-Centered Technologies Among Underserved Populations in the United States: Systematic Review
  8. 487248
    “…BACKGROUND: Cardiac involvement is common and is the leading cause of mortality in Fabry disease (FD). …”
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    Loss of base-to-apex circumferential strain gradient assessed by cardiovascular magnetic resonance in Fabry disease: relationship to T1 mapping, late gadolinium enhancement and hypertrophy
  9. 487249
    “…Finally, we demonstrated that MICA immune complexes formed with the α3 domain-specific antibody activates NKG2D on NK cells leading to the release of IFN-γ. CONCLUSIONS: Our results demonstrate that an α3 domain-specific MICA antibody can circumvent sMICA-mediated suppression of NK cell cytolytic activity. …”
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    MICA immune complex formed with alpha 3 domain-specific antibody activates human NK cells in a Fc-dependent manner
  10. 487250
    “…In the United States, about 3.5 million have chronic hepatitis C, and it is the leading cause of liver cancer and the most common indication for liver transplantation. …”
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    Comparing drug safety of hepatitis C therapies using post-market data
  11. 487251
    “…BACKGROUND: Group B Streptococcus (GBS) is a leading cause of early-onset disease (EOD) and late-onset disease (LOD) in infants. …”
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    Phenotypic and genetic differences among group B Streptococcus recovered from neonates and pregnant women in Shenzhen, China: 8-year study
  12. 487252
    “…In summary, Class II HER2-DC1 drives both a CD4 and CD8 T cell tumor infiltration that leads to increased survival, and in combination with anti-HER2 therapy and checkpoint blockade can improve survival in preclinical models of HER2 positive breast cancer and warrants exploration in patients with HER2 MBC.…”
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    Sequential Anti-PD1 Therapy Following Dendritic Cell Vaccination Improves Survival in a HER2 Mammary Carcinoma Model and Identifies a Critical Role for CD4 T Cells in Mediating the Response
  13. 487253
    “…Each single treatment reduces N-cadherin, vimentin, anillin but increases claudin-1, − 2 leading to suppression of EMT process. However, combined treatment synergistically alters these proteins to suppress EMT pathways significantly. …”
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    Reduction of metastatic potential by inhibiting EGFR/Akt/p38/ERK signaling pathway and epithelial-mesenchymal transition after carbon ion exposure is potentiated by PARP-1 inhibition in non-small-cell lung cancer
  14. 487254
    “…CONCLUSIONS: Without intervention, DENV-1 could be transmitted rapidly within a short period of time and leads to high attack rate in community in China. …”
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    Incidence dynamics and investigation of key interventions in a dengue outbreak in Ningbo City, China
  15. 487255
    “…These findings suggest that ELQ-331 warrants consideration as a leading prototype for LAI-C.…”
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    ELQ-331 as a prototype for extremely durable chemoprotection against malaria
  16. 487256
    “…Compared to scenario I, scenario III leads to an increase in QALYs by 0.44 (0.14 to 1.01) per person, and is cost-neutral. …”
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    Real-world cost-effectiveness of pan-genotypic Sofosbuvir-Velpatasvir combination versus genotype dependent directly acting anti-viral drugs for treatment of hepatitis C patients in the universal coverage scheme of Punjab state in India
  17. 487257
    “…We also found that QGR as an optimized FFPE-DNA extraction approach leads to much fewer discordant variants between paired fresh frozen and FFPE samples. …”
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    Bioinformatics and DNA-extraction strategies to reliably detect genetic variants from FFPE breast tissue samples
  18. 487258
    “…BACKGROUND: Stroke is the worldwide leading cause of long-term disabilities. Women experience more activity limitations, worse health-related quality of life, and more poststroke depression than men. …”
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    Stroke Survivors on Twitter: Sentiment and Topic Analysis From a Gender Perspective
  19. 487259
    “…BACKGROUND: Hearing loss is one of the leading causes of disability worldwide. Patients with hearing loss experience impaired quality of life, as well as emotional and financial consequences that affect both themselves and their families. …”
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    A systematic review and network meta-analysis of existing pharmacologic therapies in patients with idiopathic sudden sensorineural hearing loss
  20. 487260
    “…Molecular epidemiology indicates emerging genetic diversity in A(H3N2) viruses during the period of study, leading to co-circulation of variants. The frequency of circulating HA genetic groups was quite variable, with rapidly changing patterns of predominance. …”
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    A29 Genetic heterogeneity of influenza A (H3N2) viruses in the United Kingdom, 2016–8
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