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  1. 487281
    “…BACKGROUND: Respiratory tract infections (RTIs) are a leading cause of hospitalization and death in people age ≥65 years. …”
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    LB2. TORC1 Inhibition with RTB101 as a Potential Pan-Antiviral Immunotherapy to Decrease the Incidence of Respiratory Tract Infections Due to Multiple Respiratory Viruses in Older Adults
  2. 487282
    “…BACKGROUND: In the United States, CABP is the second most common cause of hospitalization and a leading cause of infectious death. Patients with chronic obstructive pulmonary disease (COPD)/asthma or diabetes are at risk for CABP and associated mortality. …”
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    717. Lefamulin (LEF) vs. Moxifloxacin (MOX) in Patients With Community-Acquired Bacterial Pneumonia (CABP) at Risk for Poor Efficacy or Safety Outcomes: Pooled Subgroup Analyses From the Lefamulin Evaluation Against Pneumonia (LEAP) 1 and LEAP 2 Phase 3 Noninferiority Clinical Trials
  3. 487283
    “…BACKGROUND: The second leading cause of cancer-related death in women is breast cancer. …”
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    Polymorphisms in Phase I (CYP450) Genes CYP1A1 (rs4646421), CYP1B1 (rs1056836), CYP19A1 (rs749292) and CYP2C8 (rs1058930) and Their Relation to Risk of Breast Cancer: A Case-Control Study in Mazandaran Province in North of Iran
  4. 487284
    “…The mediators might involve increased sympathetic activation, inflammation and ischemia as reflected by elevated Cyr61 levels leading to larger levels of troponin and lower LVEF. …”
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    Diabetes and baseline glucose are associated with inflammation, left ventricular function and short- and long-term outcome in acute coronary syndromes: role of the novel biomarker Cyr 61
  5. 487285
    “…IMPORTANCE: Suicidal behavior is a leading cause of death among adolescents and young adults. …”
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    Prevalence, Onset, and Course of Suicidal Behavior Among Adolescents and Young Adults in Germany
  6. 487286
    “…Background: Sepsis has been identified as a time critical and life-threatening condition resulting from the body's own systemic response to infection leading to multi-organ dysfunction and failure, and remains a major frontrunner in the morbidity and mortality of critically ill patients(1–3). …”
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    The use of screening tools in the early recognition of sepsis in the prehospital adult patient: a review of the literature
  7. 487287
    “…BACKGROUND: Prostate cancer (PCa) is a leading cause of cancer-related death in males worldwide. …”
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    Acetyl-L-Carnitine downregulates invasion (CXCR4/CXCL12, MMP-9) and angiogenesis (VEGF, CXCL8) pathways in prostate cancer cells: rationale for prevention and interception strategies
  8. 487288
    “…Specifically, it was reported that the loss of CA interactions with CPSF6 or CypA leads to higher IFN sensitivity. However, the molecular mechanism of CA adaptation to IFN sensitivity is largely unknown. …”
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    Multiple Pathways To Avoid Beta Interferon Sensitivity of HIV-1 by Mutations in Capsid
  9. 487289
    “…Tamoxifen increased ESR2-mutant TP53 interaction, leading to reactivation of TP73 and apoptosis. High levels of ESR2 expression in mutant TP53-expressing basal-like tumors is associated with better prognosis (Molecular Taxonomy of Breast Cancer International Consortium cohort: log-rank P = .001; hazard ratio = 0.26, 95% confidence interval = 0.08 to 0.84, univariate Cox P = .02). …”
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    TP53 Status as a Determinant of Pro- vs Anti-Tumorigenic Effects of Estrogen Receptor-Beta in Breast Cancer
  10. 487290
    “…BACKGROUND: Intimate partner violence (IPV) is a human rights violation and leading health burden for women. Safety planning is a hallmark of specialist family violence intervention, yet only a small proportion of women access formal services. …”
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    Efficacy of a Web-Based Safety Decision Aid for Women Experiencing Intimate Partner Violence: Randomized Controlled Trial
  11. 487291
    “…Acute gastroenteritis due to group A rotaviruses (RVAs) is the leading cause of infant and childhood morbidity and mortality particularly in developing countries including Pakistan. …”
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    Whole Genome Analysis of Selected Human Group A Rotavirus Strains Revealed Evolution of DS-1-Like Single- and Double-Gene Reassortant Rotavirus Strains in Pakistan During 2015–2016
  12. 487292
    “…Cervical cancer has become a leading cause of death in both HIV-infected and uninfected women. …”
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    Impact of antiretroviral drugs on PD-L1 expression and copy number gains with clinical outcomes in HIV-positive and -negative locally advanced cervical cancers
  13. 487293
    “…In the process of DNA replication, base mismatch often occurs due to various factors leading to abnormal expression of mismatch repair genes (MMR), among which MLH1 and MSH2 are the most important. …”
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    Clinical significance of MLH1/MSH2 for stage II/III sporadic colorectal cancer
  14. 487294
    “…BACKGROUND: Breast cancer is a leading cause of cancer-related death for women in the USA. …”
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    Cross-talk between SIM2s and NFκB regulates cyclooxygenase 2 expression in breast cancer
  15. 487295
    “…MAIN OUTCOMES AND MEASURES: A total of 23 standardized data elements collected by PCQN teams that provided information about the characteristics of referred patients, including age, sex, Palliative Performance Scale score, and primary diagnosis leading to PC consult; reason(s) given for the consultation; and processes of care provided by the PC team, including disciplines involved, number of family meetings held, advance care planning documentation completed, and screened for and intervened on needs. …”
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    Trends in Hospital-Based Specialty Palliative Care in the United States From 2013 to 2017
  16. 487296
    “…IMPORTANCE: Although cardiovascular disease is the leading cause of death in most developed countries, little is known about current physicians’ cardiovascular health and outcomes. …”
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    Comparison of Cardiovascular Risk Factors and Outcomes Among Practicing Physicians vs the General Population in Ontario, Canada
  17. 487297
    “…Further improvement in the systematic study of populations with low-level HBsAg has important clinical and epidemiological significance for improving the detection of HBV serological markers, elucidating the mechanisms leading to low-level HBsAg, overcoming immune tolerance to eliminate HBV infection and preventing HBV transmission.…”
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    Clinical characteristics and association analysis of persistent low-level HBsAg expression in a physical examination population with HBV infection
  18. 487298
    “…Timely data from online panels can inform proactive interventions against emerging trends, leading to a faster public response. However, threats to validity from using online panels must be addressed to create accurate estimates. …”
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    An Online Survey for Pharmacoepidemiological Investigation (Survey of Non-Medical Use of Prescription Drugs Program): Validation Study
  19. 487299
    “…BACKGROUND: Acute diarrhoea is a leading cause of death for children under five years of age. …”
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    Racecadotril for acute diarrhoea in children
  20. 487300
    “…However, in teleost fish, more than one PepT1-type transporter might function, due to specific whole genome duplication event(s) that occurred during their evolution leading to a more complex paralogue gene repertoire than in higher vertebrates (tetrapods). …”
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    The peptide transporter 1a of the zebrafish Danio rerio, an emerging model in nutrigenomics and nutrition research: molecular characterization, functional properties, and expression analysis
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