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487361“…Conclusion: This patient had primary aldosteronism leading to suppression of aldosterone secretion from the contralateral healthy adrenal gland. …”
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487362SAT-462 Coronary Vasospasm-Induced Myocardial Infarction: An Uncommon Presentation of Thyrotoxicosis“…ECG showed T- Wave Inversions in leads V1-V2 and ST depressions in V4-V5. Chest pain was relieved by SL nitroglycerin. …”
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487363por Kopacek, Cristiane, Wiest, Paloma, de Castro, Simone Martins, Spritzer, Poli Mara“…It is caused by mutations in the CYP21A2 gene in approximately 90% of all cases, leading to 21-hydroxylase deficiency and androgen precursors elevation. …”
Publicado 2020
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487364“…Nonalcoholic fatty liver disease (NAFLD) affects an estimated 30% of Americans, is the most common cause of chronic liver disease in the US, and a leading cause of liver-related morbidity/mortality worldwide(1). …”
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487365“…Intorduction: Breast cancer is estimated to be the third leading cause of cancer-related death in women. A commonly mutated pathway in breast cancer is the phosphoinositide-3-kinase (PI3K) pathway. …”
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487366por Khan, Aliya Aziz, Rejnmark, Lars, Schwarz, Peter E, Vokes, Tamara J, Clarke, Bart Lyman, Rubin, Mishaela Ruth, Hofbauer, Lorenz C, Erikson, Erik, Palermo, Andrea, Pagotto, Uberto, Marcocci, Claudio, Ahmed, Intekhab, Mourya, Sanchita, Markova, Denka, Karpf, David B“…Background: Hypoparathyroidism (HP) is caused by a deficiency in parathyroid hormone (PTH), which leads to hypocalcemia and hyperphosphatemia. Standard of care (SoC), i.e. large doses of calcium (Ca) and active vitamin D, worsens hypercalciuria and increases the serum Ca (sCa) x serum phosphate (sP) product. …”
Publicado 2020
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487367por Lacombe, Amanda Meneses Ferreira, Soares, Iberê Cauduro, Charchar, Helaine da Silva, Brondani, Vânia Balderrama, Neto, João Evangelista Bezerra, Tanno, Fabio, Srougi, Victor, Chambo, José Luiz, de Freitas, Ricardo Miguel Costa, Hoff, Ana Oliveira, Almeida, Madson Q, Zerbini, Maria Claudia Nogueira, Kroiss, Matthias, Fragoso, Maria Candida Barisson Villares“…Recently, it was demonstrated that SOAT1 inhibition leads to impaired steroidogenesis and cell viability in ACC [1]. …”
Publicado 2020
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487368“….*231A>G X-Linked Hypophosphatemia in Adults: A Case Study of One Family Pedigree with a Widely Variable Phenotype X-linked hypophosphatemia (XLH) is an inherited form of hypophosphatemia that is part of a group of disorders that leads to impaired bone mineralization, which can manifest as rickets in children and osteomalacia in adults. …”
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487369“…At age 18, he was noted to have hyperglycemia while undergoing dental extractions for brittle enamel leading to the diagnosis of DM. He was initiated on oral medications for a short period of time and transitioned to insulin due to significant hyperglycemia. …”
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487370“…This is a chronic inflammation of the thyroid gland caused by high serum thyroid autoantibodies leading to hypothyroidsm. In the last years, many authors worldwide have found an uncommon association between Hashimoto’s disease and nephrotic syndrome. …”
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487371por Li, Hongliang, Guo, Yankai, Zhang, Gege, Deng, Jielin, Fischer, Hayley, Craig, LaTasha B, Yu, Xichun, Kem, David C“…Conclusion: Chronic elevated GnRHR-AAb exerts induced reproductive dysfunction through increased ovarian LH secretion and androgen production, thus likely leading to compensatory hyperinsulinemia which ultimately enhanced insulin signaling in reproductive tissues to exert more and androgen production to, which may provide a novel etiological mechanism for PCOS.…”
Publicado 2020
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487372por Fowler, Melissa A, Zhao, Jian, Sturchler, Emmanuel, Rico, Elizabeth, de Necochea-Campion, Rosalia, Athanacio, Jon, Kredel, Taylor A, Antwan, Agnes, Johns, Michael, Tsivkovski, Oleg, Wang, Shmiao, Luo, Rosa, Kusnetzow, Ana Karin, Madan, Ajay, Struthers, Scott, Markison, Stacy, Zhu, Yun Fei, Betz, Stephen F“…As predicted by the in vitro pharmacology, selective nonpeptide sst5 agonists suppressed insulin secretion and raised blood glucose levels in each model, while having minimal effects on glucagon secretion. Leading sst5 agonists were also evaluated for drug like characteristics, including stability in liver microsomes, lack of inhibition of cytochromes P450 and the hERG ion channel, and were shown to exhibit good exposure upon oral dosing in both rats and dogs. …”
Publicado 2020
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487373por Patel, Richa, Berlioz, Ana Ramirez, Chinnakotla, Bhavana, Kurukulasuriya, Lilamani Romayne Goonetilleke“…Bone pain and deformities are common features and it often leads to complications such as pathological fractures, deafness or neurologic deficits. …”
Publicado 2020
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487374“…Background: Multiple studies have shown that intensive glycemic control leads to improved HbA1c and delays the onset of complications in diabetes.(1) However, improvement in glycemic control has also been associated with weight gain.(1) The High A1C (HAC) program uses a multidisciplinary team to provide intensive therapy to patients with HbA1C ≥ 10% over 3 months to improve glycemic control. …”
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487375por Murthy, Deepa Badrinath, Alvarez, Ana Gutierrez, Vargas, Wendy S, Litao, Melissa Kaori Silva, Shah, Bina Cherryl“…CONCLUSION: This is an unusual and extreme form of atrophic thyroiditis leading to near total destruction of thyroid gland related to apoptosis with autoimmunity. …”
Publicado 2020
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487376por Vecchiola, Andrea, Kato, Sumie, Liberona, Francisca, Tapia-Castillo, Alejandra, Carvajal, Cristian A, Goens, Maria Cristina, Cuello, Mauricio A, Fardella, Carlos E“…In obesity, the increase in the number and / or size of adipocytes leads to chronic low-grade systemic inflammation that conditions the development and evolution of a series of pathologies such as coronary heart disease or cancer. …”
Publicado 2020
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487377“…Liraglutide treatment leads to significant improvement in sCD163 and Gal-3 levels in obese patients. …”
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487378por de Faria, Aline Guimarães, Barroso, Priscila Sales, Ramos, Carolina, Canton, Ana Pinheiro Machado, Silva, Marina Cunha, Seraphim, Carlos Eduardo, Tinano, Flávia Rezende, Mendonca, Berenice Bilharinho, Latronico, Ana Claudia, Brito, Vinicius Nahime“…Ovarian estrogen-secreting cysts leading to peripheral precocious puberty (PPP) are some of the major clinical manifestations of the McCune-Albright syndrome (MAS). …”
Publicado 2020
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487379“…Conclusions: Commonly, MRA treatment leads to renin elevation, ARR reduction, and consequential false negative PA screening. …”
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487380por Wang, Yue, Langley, Ries J, Tamshen, Kyle, Maynard, Heather D, Jamieson, Stephen M F, Perry, Jo K“…Growth hormone (GH) is a peptide hormone that mediates actions through binding to a cell surface GH receptor (GHR), activating key signalling pathways including the JAK/STAT pathway. Excess GH secretion leads to acromegaly and tumoral expression has been implicated in cancer progression, suggesting that GH is also a potential target for anticancer therapy. …”
Publicado 2020
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