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487381por Monzani, Maria Laura, Pederzoli, Simone, Volpi, Laura, Magnani, Elisa, Diazzi, Chiara, Rochira, Vincenzo“…Background: Adult growth hormone deficiency (AGHD) is a debilitating clinical condition leading to decreased quality of life (QoL). The impact of reduced muscle mass, weakening and loss of vitality on QoL have been well characterized in AGHD. …”
Publicado 2020
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487382por Galligan, Anna, Iravani, Amir, Lasocki, Arian, Wallace, Roslyn, Weppler, Alison, Au-Yeung, George, Sachithanandan, Nirupa, Chiang, Cherie Ying, Wentworth, John, Colman, Peter Grahame, Kay, Thomas William, Krishnamurthy, Balasubramanian, Sandhu, Shahneen“…Conclusion: We report real world incidence of endocrine irAEs with combination immunotherapy. Routine biochemistry leads to the detection of some but not all cases. …”
Publicado 2020
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487383por Clines, Katrina L, Moon, Henry H, O’Day, Patrick J, Farber, Charles R, Auchus, Richard Joseph, Clines, Gregory A“…We now report an unreported function of bone as a source of T, by conversion of the adrenal androgen precursor DHEA, using 3βHSD7 as a common enzyme for androgen and bile acid synthesis, and leading to the activation of osteoblast AR signaling. …”
Publicado 2020
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487384“…Studies have shown that patients with PA have decreased expression of the CaSR leading to an autonomous rise in PTH secretion and a higher PTH-calcium set point. …”
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487385“…Ring formation subsequently leads to gene deletions on both the long and short arms of the chromosome. …”
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487386por Gafni, Rachel Ilana, Spector, Ellen J, Hartley, Iris Ruth, Redd, Bernadette, Mitnik, Gabriela Lopez, Collins, Michael T“…Background: Tumor-induced osteomalacia (TIO) is a rare cause of FGF23-mediated hypophosphatemia in which mesenchymal tumors produce ectopic FGF23, leading to renal phosphate wasting, decreased 1,25-dihydroxy-vitamin D and hypophosphatemia. …”
Publicado 2020
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487387“…Gene mutations increase the production or reduce the breakdown of fibroblast growth factor 23 leading to an overactivation of this protein and reduction of phosphate reabsorption by the kidneys, resulting in hypophosphatemia. …”
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487388por Falissard, Louis, Morgand, Claire, Roussel, Sylvie, Imbaud, Claire, Ghosn, Walid, Bounebache, Karim, Rey, Grégoire“…METHODS: The investigated dataset was based on data contained from every French death certificate from 2000 to 2015, containing information such as the subject’s age and gender, as well as the chain of events leading to his or her death, for a total of around 8 million observations. …”
Publicado 2020
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487389por Weise, Florian J., Tomeletso, Mathata, Stein, Andrew B., Somers, Michael J., Hayward, Matt W.“…Where cattle were confined in enclosures, lions preferred young inexperienced calves, often leading to considerable losses in a single incident. …”
Publicado 2020
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487390por Bronstein, Michael, Pennycook, Gordon, Joormann, Jutta, Corlett, Philip, Cannon, Tyrone“…DISCUSSION: Extant literature suggests that conflict processing deficits might encourage delusion-related cognitive biases, which is broadly consistent with the idea that these deficits may be causally primary in pathways leading to delusions. This conclusion lends credence to previous theories suggesting that reduced modulation toward analytic reasoning in the presence of conflict might promote delusions. …”
Publicado 2020
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487391“…We also demonstrate that the differential parameter values of the computational modeling of visually conditioned hallucinations differentiate between individuals with and without hallucinations, leading to better understanding of the neural signatures of hallucinations and potential therapeutic targets in clinical populations.…”
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487392por Weye, Nanna, Momen, Natalie, Christensen, Maria, Iburg, Kim, McGrath, John, Plana-Ripoll, Oleguer“…RESULTS: Alcohol use disorder and suicide were the leading causes of YLLs (alcohol use disorder: Men 568.7 YLLs, women 155.5 YLLs per 100,000 person-years; suicide: Men 590.1 YLLs, women 202.3 YLLs per 100,000 person-years). …”
Publicado 2020
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487393por Kwashie, Anita, Ma, Yizhou, Poppe, Andrew, Barch, Deanna, Carter, Cameron, Chaffee, Matthew, Gold, James, Ragland, J Daniel, Silverstein, Steven, MacDonald, Angus“…Increased task errors and reduced frontoparietal activity in proactive contexts is observed in severe psychopathology, including schizophrenia (Poppe et al., 2016), leading to the prediction that patients rely on reactive control more when performing such tasks. …”
Publicado 2020
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487394“…RESULTS: We evaluated different clinical cases of SC-induced psychoses and identified four clinical types of them on the ground of leading psychopathological syndrome during the patient’s entire length of hospitalization: 1. …”
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487395“…‘Coherent quenching’ would arise from the quantum mechanical mixing of chlorophyll and carotenoid excited state properties, leading to a reduction in chlorophyll excitation lifetime. …”
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487396por Litviakov, Nikolai, Ibragimova, Marina, Tsyganov, Matvey, Kazantseva, Polina, Deryusheva, Irina, Pevzner, Alina, Doroshenko, Artem, Garbukov, Eugeny, Tarabanovskaya, Natalia, Slonimskaya, Elena“…This paper demonstrates the significance of stemness gene amplifications leading to metastasis and stem-like cancer cell activity. …”
Publicado 2020
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487397por Sambi, Manpreet, Samuel, Vanessa, Qorri, Bessi, Haq, Sabah, Burov, Sergey V, Markvicheva, Elena, Harless, William, Szewczuk, Myron R“…Higher doses and additional drug agents can produce additional adverse effects leading to a more aggressive malignancy. Acetylsalicylic acid (ASA), metformin (Met), and oseltamivir phosphate (OP) were investigated for their efficacy to sensitize MDA-MB-231 triple-negative breast cancer and its tamoxifen (Tmx) resistant variant (MDA-MB-231-TmxR) together in combination with Tmx treatment. …”
Publicado 2020
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487398“…This study shows that refilling of harvest sites with autologous bone material taken from an hollow saw used for creation of the tibial tunnel leads to acceptable donor site morbidity, without restriction in daily activities and sports participation, respectively. …”
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487399“…METHODS: We reviewed our referral processes to identify gaps leading to prolonged wait times. On January 1, 2014, we implemented new administrative procedures: pretriage (standardized referral information form and staff training), triage (standardized clinic intake criteria and new triage guidelines), posttriage (protecting clinic spots for urgent and semi-urgent referrals, wait-list maintenance, and increasing new referral clinic capacity). …”
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487400por Awasthi, Shally, Kesarwani, Naveen, Verma, Raj Kumar, Agarwal, Girdhar Gopal, Tewari, Luxmi Shanker, Mishra, Ravi Krishna, Shukla, Lalji, Raut, Arun Kumar, Qazi, Shamim Ahmad, Aboubaker, Samira, Nisar, Yasir Bin, Bahl, Rajiv, Agarwal, Monika“…We identified 1302 infants, aged 0–59 days, with any sign of PSBI leading to a coverage of 53% (1302/2445), assuming an incidence of 10%. …”
Publicado 2020
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