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  1. 487461
    “…However, there is no available clinical decision support system for physical inactivity and poor diet, which are among the leading modifiable risk factors for chronic diseases. …”
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    Online Artículo Texto
    Impact of a Web-Based Clinical Decision Support System to Assist Practitioners in Addressing Physical Activity and/or Healthy Eating for Smoking Cessation Treatment: Protocol for a Hybrid Type I Randomized Controlled Trial
  2. 487462
    “…Traumatic brain injury (TBI) is a leading cause of death following trauma, but few early interventions improve outcomes. …”
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    Online Artículo Texto
    Association of Prehospital Plasma With Survival in Patients With Traumatic Brain Injury: A Secondary Analysis of the PAMPer Cluster Randomized Clinical Trial
  3. 487463
    “…Confirmed ORR was observed in 16 patients, for an ORR of 27.6% (95% CI 16.1% to 39.1%); 19 patients experienced stable disease, leading to a disease control rate of 60.3% (95% CI 46.4% to 73.0%). …”
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    Online Artículo Texto
    HX008, an anti-PD1 antibody, plus irinotecan as second-line treatment for advanced gastric or gastroesophageal junction cancer: a multicenter, single-arm phase II trial
  4. 487464
    “…In situ vaccination of CMP-001 is believed to activate local tumor-associated plasmacytoid dendritic cells (pDCs) leading to type I interferon secretion and tumor antigen presentation to T cells and systemic antitumor T cell responses. …”
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    In situ immunization of a TLR9 agonist virus-like particle enhances anti-PD1 therapy
  5. 487465
    “…Direct interactions were identified between these miRNAs and the 3′ UTR of Atrogin‐1, leading to repression of Atrogin‐1 and thereby induction of eIF3f protein content, in both human and mouse skeletal muscle cells. …”
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    A subset of microRNAs in the Dlk1‐Dio3 cluster regulates age‐associated muscle atrophy by targeting Atrogin‐1
  6. 487466
    “…BACKGROUND: Suicide is a leading cause of death among adolescents and more knowledge from high risk groups is needed in order to develop effective preventive strategies. …”
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    Online Artículo Texto
    Serious and persistent suicidality among European sexual minority youth
  7. 487467
    por Giebel, Godwin D
    Publicado 2020
    “…CONCLUSIONS: The use of mHealth devices to screen for AF leads to increased costs but also a reduction in the incidence of stroke. …”
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    Use of mHealth Devices to Screen for Atrial Fibrillation: Cost-Effectiveness Analysis
  8. 487468
    “…BACKGROUND: Tobacco smoking remains the leading cause of preventable death and disease worldwide. …”
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    Online Artículo Texto
    Preliminary Outcomes of a Digital Therapeutic Intervention for Smoking Cessation in Adult Smokers: Randomized Controlled Trial
  9. 487469
    “…BACKGROUND: Research from high income countries indicates that suicide is a major mental health care concern and a leading cause of preventable deaths among children and adolescents. …”
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    Online Artículo Texto
    Prevalence and risk factors for youth suicidality among perinatally infected youths living with HIV/AIDS in Uganda: the CHAKA study
  10. 487470
    “…Recent research in murine models suggests that parkin and PINK1 deficiency leads to impaired mitophagy, which causes the release of mitochondrial DNA (mtDNA), thereby triggering inflammation. …”
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    Mitochondrial damage-associated inflammation highlights biomarkers in PRKN/PINK1 parkinsonism
  11. 487471
    “…In this study, we validated that miR-518d negatively regulates the expression of PPARα and triggers the nuclear transport process of NF-κB and phosphorylation of pathway-associated proteins leading to an inflammatory response and the development of GDM.…”
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    Regulation and Mechanism of miR-518d through the PPARα-Mediated NF-κB Pathway in the Development of Gestational Diabetes Mellitus
  12. 487472
    “…Our data suggest that movement of RAP towards the heart (reduced g‐gradient), independent of foot‐level Gz, leads to improved g‐tolerance. Further investigations are required to assess the effect of differential baroreceptor feedback (i.e. aortic–carotid g‐gradient).…”
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    Effect of novel short‐arm human centrifugation‐induced gravitational gradients upon cardiovascular responses, cerebral perfusion and g‐tolerance
  13. 487473
    “…These chronic GPER1 effects are associated with the deactivation of the non-canonical MST1/YAP mechanism that leads to genetic upregulation of cell growth genes (CTGF, CYR61, PGC-1α, and ANKRD1), and downregulation of proapoptotic genes (PUMA and Bim).…”
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    Chronic GPER1 Activation Protects Against Oxidative Stress-Induced Cardiomyoblast Death via Preservation of Mitochondrial Integrity and Deactivation of Mammalian Sterile-20-Like Kinase/Yes-Associated Protein Pathway
  14. 487474
    “…BACKGROUND: Self-harm is a leading cause of morbidity in prisoners. Although a wide range of risk factors for self-harm in prisoners has been identified, the strength and consistency of effect sizes is uncertain. …”
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    Risk factors for self-harm in prison: a systematic review and meta-analysis
  15. 487475
    “…Trehalose, we delineate, activates PIKFYVE leading to TFEB nuclear translocation in MCOLN1-dependent manner to induce autophagy. …”
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    Trehalose limits opportunistic mycobacterial survival during HIV co-infection by reversing HIV-mediated autophagy block
  16. 487476
    “…From 2015 to June 2017, Madagascar achieved the required criteria leading to the acceptance of the country’s polio-free documentation in June 2018 by ARCC. …”
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    Efforts Towards Polio Eradication in Madagascar: 1997 to 2017
  17. 487477
    “…Inhibition of Ras isoprenylation with farnesyltransferase inhibitor FTI-277 leads to a significant reduction of mast cell degranulation, cytokine production, and migration. …”
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    PI3Kγ Regulatory Protein p84 Determines Mast Cell Sensitivity to Ras Inhibition—Moving Towards Cell Specific PI3K Targeting?
  18. 487478
    “…BACKGROUND: Daily monitoring of fetal and maternal conditions in complicated pregnancies leads to recurrent outpatient visits or (prolonged) hospitalization. …”
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    Online Artículo Texto
    Home-Based Monitoring and Telemonitoring of Complicated Pregnancies: Nationwide Cross-Sectional Survey of Current Practice in the Netherlands
  19. 487479
    “…BACKGROUND: Colorectal cancer (CRC) is one of the leading causes of cancer death worldwide. Emerging evidence has revealed that risk factors and metastatic patterns differ greatly between colon and rectal cancers. …”
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    Online Artículo Texto
    Biomarker Discovery for the Carcinogenic Heterogeneity Between Colon and Rectal Cancers Based on lncRNA-Associated ceRNA Network Analysis
  20. 487480
    “…BACKGROUND: Preoperative patient-specific risk factors may elucidate the mechanisms leading to the persistence of pain and opioid use after surgery. …”
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    Preoperative Factors Associated with Remote Postoperative Pain Resolution and Opioid Cessation in a Mixed Surgical Cohort: Post Hoc Analysis of a Perioperative Gabapentin Trial
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