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487541Clinical and radiographic outcomes following retrograde SIGN fin nailing for femoral shaft fracturespor Wilson, Nathaniel M., Moen, Matthew T., Shaw, Jordan T., Graf, Ryan M., Behlmer, Richard J., Simske, Natasha M., Zirkle, Lewis G., Whiting, Paul S.“…A newer design iteration, the SIGN Fin nail, was developed to further simplify retrograde femoral nailing by making proximal interlocking screw placement unnecessary. Instead, the leading end of the Fin nail achieves stability through an interference fit within the proximal femoral canal. …”
Publicado 2020
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487542por Lin, Fang, Nie, Shan, Zhao, Ranran, Cao, Min, Yuan, Wei, Li, Yunxiao, Tan, Chunting, Xu, Bo, Wang, Haoyan“…RESULTS: Compared to control, the slope (30.58±3.62, P<0.001) and intercept (4.85±1.11 L/min, P<0.05) were higher in COPD(stages1-2), leading to a higher nadir (31.47±4.47, P<0.01). Despite an even higher intercept in COPD(stages3-4) (7.16±1.41, P<0.001), the slope diminished with disease progression (from 30.58±3.62 in COPD(stages1-2) to 26.84±4.96 in COPD(stages3-4), P<0.01). …”
Publicado 2021
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487543“…BACKGROUND: Workplace musculoskeletal disorders are the leading cause of morbidity and disability in the Australian workforce. …”
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487544por Feng, Xing, Zhang, Heng, Meng, Lingbing, Song, Huiwen, Zhou, Qingxin, Qu, Chao, Zhao, Pan, Li, Qinghua, Zou, Chang, Liu, Xing, Zhang, Zhiyong“…Mechanistically, hypoxia induces ELP3-mediated PAK1 acetylation at K420, which suppresses the dimerization of PAK1 and enhances its activity, thereby leading to subsequent PAK1-mediated ATG5 (autophagy related 5) phosphorylation at the T101 residue. …”
Publicado 2020
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487545por Langlet, Billy Sundström, Odegi, Dorothy, Zandian, Modjtaba, Nolstam, Jenny, Södersten, Per, Bergh, Cecilia“…BACKGROUND: Anorexia nervosa is one of the more severe eating disorders, which is characterized by reduced food intake, leading to emaciation and psychological maladjustment. …”
Publicado 2021
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487546por Santi, Maristella, Graf, Stefanie, Zeino, Mazen, Cools, Martine, Van De Vijver, Koen, Trippel, Mafalda, Aliu, Nijas, Flück, Christa E“…LEARNING OBJECTIVES: Identify the precise pathophysiologic mechanisms leading to virilization in girls at puberty considering that virilization at puberty may be the first manifestation of an endocrine active tumor or a disorder/difference of sex development (DSD) that remained undiagnosed before and may be life-threatening. …”
Publicado 2020
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487547por Sardu, Celestino, Modugno, Pietro, Castellano, Gaetano, Scisciola, Lucia, Barbieri, Michelangela, Petrella, Lella, Fanelli, Mara, Macchia, Gabriella, Caradonna, Eugenio, Massetti, Massimo, Paolisso, Giuseppe, Marfella, Raffaele“…Atherosclerotic plaque instability and rupture in patients with asymptomatic carotid artery stenosis (ACAS) is a leading cause of major adverse cardiac events (MACE). …”
Publicado 2021
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487548por McFarlane, Philip A., Bitzan, Martin, Broome, Catherine, Baran, Dana, Garland, Jocelyn, Girard, Louis-Philippe, Grewal, Kuljit, Lapeyraque, Anne-Laure, Patriquin, Christopher Jordan, Pavenski, Katerina, Licht, Christoph“…Finally, aHUS occurs in the setting of inherited or acquired abnormalities in the alternative complement pathway leading to dysregulated complement activation, often following a triggering event such as an infection. …”
Publicado 2021
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487549por Gao, Min, Piernas, Carmen, Astbury, Nerys M, Hippisley-Cox, Julia, O'Rahilly, Stephen, Aveyard, Paul, Jebb, Susan A“…INTERPRETATION: At a BMI of more than 23 kg/m(2), we found a linear increase in risk of severe COVID-19 leading to admission to hospital and death, and a linear increase in admission to an ICU across the whole BMI range, which is not attributable to excess risks of related diseases. …”
Publicado 2021
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487550por Kempen, Thomas G. H., Bertilsson, Maria, Hadziosmanovic, Nermin, Lindner, Karl-Johan, Melhus, Håkan, Nielsen, Elisabet I., Sulku, Johanna, Gillespie, Ulrika“…IMPORTANCE: Suboptimal use of medications is a leading cause of health care–related harm. Medication reviews improve medication use, but evidence of the possible benefit of inpatient medication review for hard clinical outcomes after discharge is scarce. …”
Publicado 2021
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487551por Xu, Xiaomin, Chen, Shujuan, Chen, Junning, Chen, Zhikang, Fu, Liming, Song, Dingchen, Zhao, Min, Jiang, Haifeng“…However, multiple problems occurred in the implementation process, leading to a low detoxification rate in the community. …”
Publicado 2021
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487552por Silberzahn, Bradley E, Tomko, Catherine A, Clouse, Emily, Haney, Katherine, Allen, Sean T, Galai, Noya, Footer, Katherine H A, Sherman, Susan G“…RESULTS: We hypothesize that addressing structural drivers and more immediate medical needs, in combination with peer outreach, will improve the HIV and STI risk environment, leading to community empowerment, and reduce the HIV and STI cumulative incidence and behavioral risks of FSWs. …”
Publicado 2021
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487553por Park, Linda G, Elnaggar, Abdelaziz, Lee, Sei J, Merek, Stephanie, Hoffmann, Thomas J, Von Oppenfeld, Julia, Ignacio, Nerissa, Whooley, Mary A“…BACKGROUND: Cardiac rehabilitation (CR) is an exercise-based program prescribed after cardiac events associated with improved physical, mental, and social functioning; however, many patients return to a sedentary lifestyle leading to deteriorating functional capacity after discharge from CR. …”
Publicado 2021
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487554“…Introduction: Infant birth weight is recognized as the leading indicator of health among infants and affects a wide range of subsequent outcomes later in life. …”
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487555por Kurniawan, Farid, Deaningtyas, Primasari, Tahapary, Dicky Levenus, Purnamasari, Dyah, Pradnjaparamita, Tika, BioMed, M, Harbuwono, Dante Saksono, Sartono, Erliyani, Yazdanbakhsh, Maria, Soewondo, Pradana“…This change might influence the gut environment, which based on recent studies, could interact with the immune system leading to inflammation and contribute to the pathogenesis of obesity and T2D. …”
Publicado 2021
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487556por Risbridger, Gail Petuna, Porter, Laura Helen, Zhu, Joe, Byrne, David, Lister, Natalie, Azad, Arun, Hofman, Michael, Vela, Ian, Taylor, Renea A, Neeson, Paul, Darcy, Phil, Trapani, Joseph“…This demonstrated canonical activation of granule exocytosis pathway by the CAR T cells, leading to organoid cell death. To assess CAR T cell efficacy in vivo, we selected one PDX with high LeY expression. …”
Publicado 2021
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487557por Figueroa-Cruz, Alegyari, Villarrubia-Ocasio, Lisselle M, Madera-Marin, Luis N, Ortiz-Torres, Yineli, Vazquez-Roura, Francis, Garcia-Mateo, Jose M“…An exact dose intake that leads to intoxication has not yet being stablished but supplementation besides dosage is also dependent on duration of therapy. …”
Publicado 2021
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487558“…Adrenoleukodystrophy (ALD) is a peroxisomal disorder which leads to the accumulation of very long-chain fatty acids in all tissues. …”
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487559“…Intuitively, loss-of-function variants affecting any of the subunits should equally diminish SDH function leading to succinate accumulation and tumorigenesis after loss of heterozygosity. …”
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487560por Mukaddam, Mona Al, Hvisdas, Christopher, Sulaj, Anisa, Patel, Kruti, Tran, Richie“…When sclerostin is inhibited, stimulation of this pathway leads to increased bone formation and production of osteoprotegerin, which also decreases bone resorption. …”
Publicado 2021
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