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  1. 487541
    “…A newer design iteration, the SIGN Fin nail, was developed to further simplify retrograde femoral nailing by making proximal interlocking screw placement unnecessary. Instead, the leading end of the Fin nail achieves stability through an interference fit within the proximal femoral canal. …”
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  2. 487542
    “…RESULTS: Compared to control, the slope (30.58±3.62, P<0.001) and intercept (4.85±1.11 L/min, P<0.05) were higher in COPD(stages1-2), leading to a higher nadir (31.47±4.47, P<0.01). Despite an even higher intercept in COPD(stages3-4) (7.16±1.41, P<0.001), the slope diminished with disease progression (from 30.58±3.62 in COPD(stages1-2) to 26.84±4.96 in COPD(stages3-4), P<0.01). …”
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  3. 487543
    “…BACKGROUND: Workplace musculoskeletal disorders are the leading cause of morbidity and disability in the Australian workforce. …”
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  4. 487544
    “…Mechanistically, hypoxia induces ELP3-mediated PAK1 acetylation at K420, which suppresses the dimerization of PAK1 and enhances its activity, thereby leading to subsequent PAK1-mediated ATG5 (autophagy related 5) phosphorylation at the T101 residue. …”
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  5. 487545
    “…BACKGROUND: Anorexia nervosa is one of the more severe eating disorders, which is characterized by reduced food intake, leading to emaciation and psychological maladjustment. …”
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  6. 487546
    “…LEARNING OBJECTIVES: Identify the precise pathophysiologic mechanisms leading to virilization in girls at puberty considering that virilization at puberty may be the first manifestation of an endocrine active tumor or a disorder/difference of sex development (DSD) that remained undiagnosed before and may be life-threatening. …”
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  7. 487547
  8. 487548
    “…Finally, aHUS occurs in the setting of inherited or acquired abnormalities in the alternative complement pathway leading to dysregulated complement activation, often following a triggering event such as an infection. …”
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  9. 487549
    “…INTERPRETATION: At a BMI of more than 23 kg/m(2), we found a linear increase in risk of severe COVID-19 leading to admission to hospital and death, and a linear increase in admission to an ICU across the whole BMI range, which is not attributable to excess risks of related diseases. …”
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  10. 487550
    “…IMPORTANCE: Suboptimal use of medications is a leading cause of health care–related harm. Medication reviews improve medication use, but evidence of the possible benefit of inpatient medication review for hard clinical outcomes after discharge is scarce. …”
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  11. 487551
  12. 487552
    “…RESULTS: We hypothesize that addressing structural drivers and more immediate medical needs, in combination with peer outreach, will improve the HIV and STI risk environment, leading to community empowerment, and reduce the HIV and STI cumulative incidence and behavioral risks of FSWs. …”
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  13. 487553
    “…BACKGROUND: Cardiac rehabilitation (CR) is an exercise-based program prescribed after cardiac events associated with improved physical, mental, and social functioning; however, many patients return to a sedentary lifestyle leading to deteriorating functional capacity after discharge from CR. …”
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  14. 487554
    por Athar, Sufia, Tellisi, Amna Khalifa
    Publicado 2021
    “…Introduction: Infant birth weight is recognized as the leading indicator of health among infants and affects a wide range of subsequent outcomes later in life. …”
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  15. 487555
    “…This change might influence the gut environment, which based on recent studies, could interact with the immune system leading to inflammation and contribute to the pathogenesis of obesity and T2D. …”
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  16. 487556
    “…This demonstrated canonical activation of granule exocytosis pathway by the CAR T cells, leading to organoid cell death. To assess CAR T cell efficacy in vivo, we selected one PDX with high LeY expression. …”
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  17. 487557
    “…An exact dose intake that leads to intoxication has not yet being stablished but supplementation besides dosage is also dependent on duration of therapy. …”
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  18. 487558
    “…Adrenoleukodystrophy (ALD) is a peroxisomal disorder which leads to the accumulation of very long-chain fatty acids in all tissues. …”
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  19. 487559
    por Gruber, Lucinda, Maher, L James
    Publicado 2021
    “…Intuitively, loss-of-function variants affecting any of the subunits should equally diminish SDH function leading to succinate accumulation and tumorigenesis after loss of heterozygosity. …”
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  20. 487560
    “…When sclerostin is inhibited, stimulation of this pathway leads to increased bone formation and production of osteoprotegerin, which also decreases bone resorption. …”
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