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  1. 487561
    por Niaz, Azra, Sophia, Ali
    Publicado 2021
    “…This abnormal fat redistribution leads to a characteristic phenotype and severe metabolic derangements that are difficult to manage. …”
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  2. 487562
    “…Several clinical characteristics of Cushing’s syndrome such as insulin resistance and hirsutism may overlap with normal variants of pregnancy and therefore leading to a missed diagnosis. We hereby present a case of a young pregnant woman with severe insulin resistance, with workup consistent with Cushing’s syndrome. …”
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  3. 487563
    por Wirtshafter, Stephanie, Iqbal, Iqra
    Publicado 2021
    “…A diagnosis of Hashimoto’s thyroiditis leading to subclinical hypothyroidism was made. Patient was discharged on vitamin B12 and 112mcg of Synthroid. …”
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  4. 487564
    por Miller, Assia, Bargman, Renee
    Publicado 2021
    “…Mutation in hepatocyte nuclear factor-1β (HNF-1β) gene results in an error of embryonic development of pancreas and nephron, leading to MODY type 5. MODY 5 accounts for 1% of maturity-onset diabetes of the young. …”
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  5. 487565
    “…Increased systemic capillary permeability and decreased lymphatic drainage of albumin which leads to increased pericardial colloid pressure are proposed mechanisms for hypothyroid PE. …”
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  6. 487566
    por Goak, Insun, Jang, Seol A, Park, Ji Hyun
    Publicado 2021
    “…Background: Cerebrotendinous xanthomatosis (CTX) is a rare autosomal recessive disease where deficiency of sterol 27-hydroxylase leads to reduced production of CDCA. In such cases, life expectancy is only 4–6 decades, with progressive neurologic dysfunction such as dementia and spinal cord paresis, unless the condition is diagnosed early and treated appropriately. …”
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  7. 487567
    “…During this treatment, he developed significant calcification of the peripheral veins at the site of administration, leading to intravenous therapy suspension. The dose of oral calcium, calcitriol and magnesium was gradually increased and sevelamer started to control hyperphosphatemia. …”
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  8. 487568
    “…Clinical Lesson/Conclusion: Significant, sudden leukocytosis and hypercalcemia prompted further evaluation of his long-standing apparently benign thyroid nodule leading to a diagnosis of anaplastic thyroid cancer. …”
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  9. 487569
    “…The mutation was detected at pArg438His indicating a single nucleotide substitution leading to the replacement of arginine by histidine at the p.438 of the translated protein on exon 10. …”
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  10. 487570
    “…Benign Prostatic hyperplasia (BPH) is a leading cause of lower urinary tract symptoms which affects men above 50 years of age. …”
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  11. 487571
    “…These findings highlight the complexity and dynamics of the decidual immune cell landscape during the transition from myometrial quiescence to contractility, and the fetal-maternal interactions leading to parturition. Support: NIH grants R01-HL050022 (CRM) and P01-HD087150 (CRM), Burroughs Wellcome Preterm Birth Grant #1019823 (CRM).…”
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  12. 487572
    “…Studies demonstrate that aldosterone excess has blood pressure independent proinflammatory and profibrotic effects on the vessel wall which leads to endothelial dysfunction and thus accelerated atherosclerosis. …”
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  13. 487573
    “…She was placed on a strict calorie restricted diet leading up to the surgery. Empagliflozin and metformin were held 1 day prior to the surgery, insulin was decreased. …”
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  14. 487574
    “…There is a decrease in the functionality of the muscular unit in producing strength in this group of TWs since strength decreased disproportionately to muscle mass which leads us to believe that there are important functional changes in intracellular oxidation mechanism.…”
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  15. 487575
    “…Not only does OIAI impair patients’ quality of life and potentially escalate their opioid dosage by inexperienced prescribers, it also leads to catastrophic adrenal crisis following acute insults. …”
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  16. 487576
    “…Introduction: Familial partial lipodystrophy (FPLD) syndromes are genetic disorders characterized by selective lipoatrophy affecting the upper and lower extremities leading to severe insulin resistance and metabolic complications. …”
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  17. 487577
    “…Urea increases renal water excretion due to osmotic diuresis and reduce urinary sodium leading to an increase in serum sodium. This case illustrates the effect and safe use of urea in a hospitalized patient with SIADH. …”
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  18. 487578
    “…Background: Obesity is an increasing global health problem worldwide and Uruguay mirrors these trends. It leads to various complications that include non-alcoholic fatty liver disease (NAFLD). …”
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  19. 487579
    por Mishra, Ritu, Mendelson, Carole R
    Publicado 2021
    “…Overall, our studies suggest a key role of the miR-29 family and its targets in prevention of inflammatory and profibrotic signaling in the neonatal lung leading to lung pathology. Supported by: NIH R01-HL050022 (C.R.M.) …”
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  20. 487580
    “…Aim: To decipher genetic etiologies among a large single-center cohort of SGA-SS children and to stratify them according to molecular mechanisms leading to pre- and postnatal growth failure. Patients/Methods: In our center 447 children (223 females) fulfilled the criteria of SGA-SS. …”
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