“…By specifically binding miR-148b-3p, it weakened the negative regulatory effects of miR-148b-3p on the ICAM-1 target gene leading to upregulated expression of ICAM-1. This interaction was also shown to inhibit HUVEC proliferation and enhance apoptosis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…We also found that Rbm38(−/−);Trp73(+/−) mice exhibited weak expression of SPRR2A/2D in multiple tissues and were susceptible to systemic chronic inflammation, suggesting that decreased SPRR2A/2D expression is likely responsible for chronic inflammation in Rbm38(−/−);Trp73(+/−) mice, leading to a shortened lifespan. Together, our data reveal that SPRR2A/2D are novel targets of the RBM38-p73 loop and contribute to p73-dependent suppression of chronic inflammation.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The exposure to muscle relaxants frequently leads to adverse effects despite their modest therapeutic efficacy, but whether muscle relaxants predispose users to frailty remains unclear. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…On the basis of the key parameters for the one-pot synthesis strategy of {Bi(3)W(43)}, a rational step-by-step approach was developed using the known Krebs-type polyoxotungstate (POT) K(12)[Sb(V)(2)W(VI)(22)O(74)(OH)(2)]·27H(2)O {Sb(2)W(22)} as a nonlacunary precursor leading to the synthesis and characterization of {Sb(3)W(43)} and {Co(3)Sb(3)W(42)}. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…OBJECTIVE: Low back pain is a leading cause of disabilities worldwide, and intervertebral disc degeneration (IVDD)-related disorders have been recognised as one of the main contributors. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Despite substantial scale-up of HIV services, HIV disease remains a leading cause of death in western Kenya. Despite progress, increased efforts remain necessary to prevent and treat HIV infection and disease.…”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Only 7.8% (95% CI ±3.0%) of all patients were appropriately managed without additional referral. 1.3% (95% CI ±1.3%) of scans revealed diagnoses leading to change in treatment (therapeutic yield). …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…IMPORTANCE: Tobacco use prevalence among individuals involved in the criminal-legal system is 125% higher than that of the general population and leads to high levels of smoking-related morbidity and mortality. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…Clinical cases: Case 1: A 54-year-old female with a history of multiple traumatic brain injuries (multiple falls and a ski accident) complained of years of insatiable hunger leading to hyperphagia and over 20 pounds weight gain. …”
Enlace del recurso
Enlace del recurso

“…Background: Nearly 50% of cancer patients suffer from cancer cachexia, a wasting syndrome with atrophy of white adipose tissue (WAT) and skeletal muscle. Cachexia leads to negative energy balance, limits cancer therapies, and reduces survival rate. …”
Enlace del recurso
Enlace del recurso

“…Yet, resistance often develops leading to castration-resistant prostate cancer (CRPC). …”
Enlace del recurso
Enlace del recurso

“…Purpose: Gender dysphoria is defined as a significant incongruence between an individual’s experienced gender and the gender assigned at birth, leading to persistent distress. Hormone therapy and gender affirmation surgery improve gender dysphoria by mitigating or completely removing undesirable primary/secondary sexual characteristics which would better align with one’s physical and psychological features. …”
Enlace del recurso
Enlace del recurso

“…Background: Peak stimulated growth hormone (GH) levels are known to decrease with increasing BMI, possibly leading to overdiagnosis of GH deficiency (GHD) in children with overweight and obesity. …”
Enlace del recurso
Enlace del recurso

“…Since thyroid hormones are known to increase erythropoietin, this leads to an exaggerated consumption of iron, folic acid and vitamin B12 and can cause various forms of anemias. …”
Enlace del recurso
Enlace del recurso

“…Insulin and somatostatin (SST) secretions from β- and δ-cells, respectively, are stimulated by glucose by mechanisms involving an inhibition of their ATP-sensitive K(+) (K(ATP)) channels, leading to an increase in [Ca(2+)](c) that triggers exocytosis. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Plasmodium falciparum is the most deadly and leading cause of morbidity and mortality in Africa. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…RESULTS: By testing T-cell recognition of OVA and DBY on a murine B-cell line overexpressing H2-M and H2-O, respectively, we showed that OVA leads to a stronger T-cell activation in the presence of H2-O demonstrating its DM-sensitivity. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…BACKGROUND: Trachoma is the second leading cause of blindness in the world affecting the poorest communities. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…UV 328 was found to be oxidized at its alkyl side chains leading to the formation of hydroxy and/or oxo function with maximum blood concentrations at 8–10 h after exposure for UV 328-6/3-OH, UV 328-4/3-OH and UV 328-4/3-CO. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…The bacterial plaque and its toxic byproducts sometimes migrate inside the blood vessels and get lodged in the arterial wall known as atheroma which is found to be a leading cause for heart disease. Various host products are seen to be elevated in the human body as the result of the inflammation. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso