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  1. 487821
    “…Literature data confirmed that the addition of pertuzumab to a standard neoadjuvant chemotherapy backbone (either with or without anthracyclines), in patients with human epidermal growth factor receptor 2 (HER2)-positive early breast cancer (EBC), leads to a higher pathological complete response (pCR) rate, which is known to correlate with a better prognosis. …”
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    Anthracycline-Free Neoadjuvant Treatment in Patients with HER2-Positive Breast Cancer: Real-Life Use of Pertuzumab, Trastuzumab and Taxanes Association with an Exploratory Analysis of PIK3CA Mutational Status
  2. 487822
    “…These data indicate that CLAG-M/GO3 is safe and leads to superior outcomes than CLAG-M alone in favorable-risk AML/high-grade myeloid neoplasm.…”
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    Phase 1/2 Trial of CLAG-M with Dose-Escalated Mitoxantrone in Combination with Fractionated-Dose Gemtuzumab Ozogamicin for Newly Diagnosed Acute Myeloid Leukemia and Other High-Grade Myeloid Neoplasms
  3. 487823
    “…Participants identified 3 key groups of barriers that led to difficulties: the wider ecosystem at many Bavarian health care organizations, legal uncertainty that leads to risk-adverse approaches, and ethical positions that patient consent ought to be obtained whenever possible to respect patient autonomy. …”
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    Practices and Attitudes of Bavarian Stakeholders Regarding the Secondary Use of Health Data for Research Purposes During the COVID-19 Pandemic: Qualitative Interview Study
  4. 487824
    “…IMPORTANCE Contamination of food by Listeria monocytogenes at retail level leads to potential consumption of contaminated food with high risk of human infection. …”
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    Dissecting Listeria monocytogenes Persistent Contamination in a Retail Market Using Whole-Genome Sequencing
  5. 487825
    “…Serological surveillance studies of infectious diseases provide population-level estimates of infection and antibody prevalence, generating crucial insight into population-level immunity, risk factors leading to infection, and effectiveness of public health measures. …”
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    Development and Implementation of Dried Blood Spot-Based COVID-19 Serological Assays for Epidemiologic Studies
  6. 487826
    “…Analysis of predicted hexon protein structures indicated that aa188 mutation leads to conformational changes in the L1 loop of HNJZ-hexon but not in ON1-hexon. …”
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    The Role of Hexon Amino Acid 188 Varies in Fowl Adenovirus Serotype 4 Strains with Different Virulence
  7. 487827
    “…Estimates of protection against symptomatic infections and infections leading to hospitalisation were also calculated. The prevalence of infections classified as symptomatic or asymptomatic was compared for primary infections and reinfections. …”
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    Observed protection against SARS-CoV-2 reinfection following a primary infection: A Danish cohort study among unvaccinated using two years of nationwide PCR-test data
  8. 487828
    “…Grade 3/4 treatment-related adverse events (TRAEs) were reported in 37.5%, 35.7%, 20%, 66.7%, and 35.3% of patients, respectively. No TRAEs leading to treatment discontinuation and no grade 5 TRAEs were observed. …”
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    Biomarker-guided targeted therapy in platinum-resistant ovarian cancer (AMBITION; KGOG 3045): a multicentre, open-label, five-arm, uncontrolled, umbrella trial
  9. 487829
    “…CONCLUSION: TST33 mega anastomotic hemorrhoidectomy treatment for patients with severe prolapse hemorrhoids, leads to less postoperative pain, the rapid recovery of perianal edema and has fewer complications.…”
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    Evaluation of the clinical efficacy and safety of TST33 mega hemorrhoidectomy for severe prolapsed hemorrhoids
  10. 487830
    por Takeda, Makio, Suzuki, Takeshi
    Publicado 2022
    “…This induces Rab 8 phosphorylation and exocytosis of PTTH, leading to termination of diapause. All the PTTH-expressing neurons have PKC-ir, and Rab8-ir. …”
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    Circadian and Neuroendocrine Basis of Photoperiodism Controlling Diapause in Insects and Mites: A Review
  11. 487831
    “…BACKGROUND: Hepatitis C virus (HCV) is a leading cause of liver cirrhosis and hepatocellular carcinoma globally. …”
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    Efficacy and safety of sofosbuvir/velpatasvir with or without ribavirin in hepatitis C genotype 3 compensated cirrhosis: A meta-analysis
  12. 487832
    “…CONCLUSION: Strong conclusive evidence indicates that viscosupplementation leads to a small reduction in knee osteoarthritis pain compared with placebo, but the difference is less than the minimal clinically important between group difference. …”
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    Viscosupplementation for knee osteoarthritis: systematic review and meta-analysis
  13. 487833
    “…Taken together, the CBF response to iSD displayed typical features of spreading ischemia, whereas the transient CBF reduction with aSD appeared to be a passive decrease of CBF following the anoxia-related hypotension, leading to aSD. CONCLUSIONS: We propose that the dysfunction of cerebrovascular autoregulation that occurs simultaneously with hypotension transients poses a substantial risk of SD occurrence and is not a consequence of SD. …”
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    Transient Hypoperfusion to Ischemic/Anoxic Spreading Depolarization is Related to Autoregulatory Failure in the Rat Cerebral Cortex
  14. 487834
    “…BACKGROUND: Families have faced unprecedented challenges during the COVID-19 pandemic, leading to increased maternal mental health problems and barriers to accessing care. …”
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    Building Emotional Awareness and Mental Health (BEAM): A Pilot Randomized Controlled Trial of an App-Based Program for Mothers of Toddlers
  15. 487835
    por Lin, Dan, Zhu, Hongkai
    Publicado 2022
    “…From the perspective of integration, study the resource advantages and penetration path of national high power status values leading ideological and political education in Colleges and universities, promote the organic combination of class education and value orientation, and build a scientific, systematic and sustainable long-term mechanism of value education. …”
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    ON THE LONG-TERM CONSTRUCTION OF IDEOLOGICAL AND POLITICAL EDUCATION SYSTEM IN COLLEGES AND UNIVERSITIES GUIDED BY THE STATUS AND VALUES OF NATIONAL SENIOR OFFICIALS—BASED ON STUDENTS' EMOTIONAL BEHAVIOR DRIVING FACTORS
  16. 487836
    “…For example, perfluorinated compounds can concentrate in the human body, or they can be transferred to the baby during breastfeeding, thus leading to serious health risks. Phthalate esters may cause damage to the liver, lungs, and kidneys. …”
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    用于食品安全分析样品前处理的共价有机聚合物的制备及应用进展
  17. 487837
    “…These findings will contribute to the optimization of the prototypes, leading to the development of an EHT that helps facilitate shared decision making. …”
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    Development of a Patient-Centered Preference Tool for Patients With Hematologic Malignancies: Protocol for a Mixed Methods Study
  18. 487838
    “…Moreover, it investigates the pathophysiologic mechanisms leading to HA in SAH. METHODS: Patients with SAH admitted to the neurological intensive care unit and patients (American Society of Anesthesiologists physical status of 1 and 2) undergoing elective surgery under spinal anesthesia were enrolled. …”
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    Cerebrospinal Fluid and Arterial Acid–Base Equilibrium of Spontaneously Breathing Patients with Aneurismal Subarachnoid Hemorrhage
  19. 487839
    “…BACKGROUND: In experimental animal models, implantation location might influence the heterogeneity and overall development of the tumor, leading to an interpretation bias. PURPOSE: To investigate the effects of implantation location in experimental tumor model using magnetic resonance imaging (MRI) and pathological findings. …”
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    Orthotopic Versus Allotopic Implantation: Comparison of Radiological and Pathological Characteristics
  20. 487840
    “…This similarity prompted our realisation that the capacity for whole‐body endothermy could even have pre‐dated the divergence of Amniota into Synapsida and Sauropsida, leading us to hypothesise the homology of whole‐body endothermy in birds and mammals, in contrast to the current assumption of their independent (convergent) evolution. …”
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    Whole‐body endothermy: ancient, homologous and widespread among the ancestors of mammals, birds and crocodylians
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