“…Background The coronavirus disease 2019 (COVID-19) pandemic provoked disruptions in healthcare delivery, leading to the cancellation and postponement of various health services, including surgery. …”
Enlace del recurso
Enlace del recurso
Enlace del recurso

“…In PA, excess production of aldosterone leads to downregulation of renin and an elevated aldosterone-to-renin ratio (ARR). …”
Enlace del recurso
Enlace del recurso

“…Prenatal testosterone (T) treatment from gestational days (GD) 30-90 (sexually dimorphic window of fetal development where male fetuses naturally see elevated T) leads to reproductive and metabolic disruptions in female sheep that includes dyslipidemia, insulin resistance, and compensatory hyperinsulinemia similar to that seen in women with PCOS. …”
Enlace del recurso
Enlace del recurso

“…The views expressed in this publication represent those of the author(s) and do not necessarily represent the official views of HCA Healthcare or any of its affiliated entities.Introduction Cushing’s syndrome (CS) is associated with a hypercoagulable state leading to increased incidence of thromboembolic events. …”
Enlace del recurso
Enlace del recurso

“…We describe an ACC patient with a history of fatty liver disease and mixed hyperlipidemia who developed severe hypertriglyceridemia and acute pancreatitis leading to multiorgan failure about one month after starting mitotane. …”
Enlace del recurso
Enlace del recurso

“…Type 1 diabetes (T1D) is an autoimmune disease, characterized in part by islet inflammation and macrophage infiltration leading to β-cell injury and loss. The inflammatory mediator 12/15-lipoxygenase (12/15-LOX) and its lipid product 12-hydroxyeicosatetraenoic acid (12-HETE) have both been implicated in T1D. 12-HETE activates the low affinity receptor leukotriene B4 receptor 2 (LTB4R2, or simply BLT2), which was reported as a low-affinity receptor for 12-HETE, suggesting that BLT2 may play a proinflammatory role. …”
Enlace del recurso
Enlace del recurso

“…Within the multidimensional network of factors leading to reduced BMD and lean mass, an imbalanced E2/TT ratio seems to be more relevant rather than TT or E2 alone. …”
Enlace del recurso
Enlace del recurso

“…This arises due to myocardial necrosis from factors such as severe acidosis, concomitant infection, and significant dehydration leading to supply/demand mismatch etc. Regardless, patients with troponin elevation admitted for DKA have increased mortality ,longer hospital stay, increased total hospital charges along with several inpatient complications compared to those without any evidence of troponin elevation. …”
Enlace del recurso
Enlace del recurso

“…Pheochromocytomas (PCC) and paragangliomas can develop in up to 8% of patients with NF type 1. Vasculopathy leading to vascular narrowing and malformations are also well described manifestations of NF. …”
Enlace del recurso
Enlace del recurso

“…Background: Diabetic retinopathy is the leading cause of blindness in working-age Americans. …”
Enlace del recurso
Enlace del recurso

“…This suggests adifferent mechanism involved in the eunuchoid skeleton development between CHH and KS confirming a major role for estrogen/androgen deficiency in the former (leading to disproportional growth of both legs and arms due to delay in epiphyseal closure that could benefit from on timereplacement treatment) and a possible role of genetic supernumerary X in the latter, displaying a disproportional growth only at the legs site since infancy. …”
Enlace del recurso
Enlace del recurso

“…We report a rare case of poorly controlled type 1 diabetes leading to functional hypogonadotropic hypogonadism as well as failure to thrive. …”
Enlace del recurso
Enlace del recurso

“…The ”Glucagon in MODY” study was a non-randomized interventional pilot study (NCT03246828), aiming to investigate whether fasting and post-prandial glucagon levels are raised in MODY3 & MODY1 patients, and whether gliclazide treatment leads to more physiological glucose-induced glucagon suppression in this population. …”
Enlace del recurso
Enlace del recurso

“…At what point this compensation is overwhelmed leading to inflammation and cellular lipotoxicity remains to be determined. …”
Enlace del recurso
Enlace del recurso

“…Hypothesis: EGF/EGFR induces an EGF-TBX19-EGFR positive feedback loop that subsequently leads to the expression of the CD44v9/SLC7A11 antioxidant system within radiation-therapy resistant SOX2+ corticotroph PitNET cells. …”
Enlace del recurso
Enlace del recurso

“…It is even rarer to have a new diagnosis of diabetes leading to DKA in pregnancy just before evaluation at the standard 28 weeks like the events precipitated in this case. …”
Enlace del recurso
Enlace del recurso

“…Introduction An autonomous nodule with autonomous function on scintigraphy, usually (but not always) leading to hyperthyroidism are representing by around 5-10% of solitary thyroid nodules. …”
Enlace del recurso
Enlace del recurso

“…LpX has been detected in patients with graft-versus-host disease (GVHD) of the liver. Cholestasis leads to the accumulation of bile salts and UC in the circulation, promoting the formation of LpX. …”
Enlace del recurso
Enlace del recurso

“…Coronary artery disease (CAD) is the leading cause of global mortality. Although exercise training mitigates CAD progression, the mechanisms by which exercise training impacts epicardial adipose tissue (EAT) are unknown. …”
Enlace del recurso
Enlace del recurso

“…The Effect of Testosterone Replacement Therapy on NAFLD in Elderly Hypogonadal Men Background: Aging increases body weight, visceral fat, insulin resistance and metabolic syndrome, leading to increased prevalence of nonalcoholic fatty liver disease(NAFLD) in elderly. …”
Enlace del recurso
Enlace del recurso