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488221“…Oral E2 was again held for an additional four days, leading to total estrogen level of 119 pg/mL (56-213 pg/mL) and total testosterone of 18 ng/dL (264-916 ng/dL). …”
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488222por Stezzi, Marc, Hayes, Clarissa, Misiura, Merissa, Skutnik, Emily, Anne Perilli, Gretchen, Koshy, Sharmila“…Primary hyperparathyroidism is the leading cause of hypercalcemia in pregnancy. Management presents a challenge as drug treatment and surgery options are limited. …”
Publicado 2023
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488223por Al-Naqeeb, Ghadah, Ghosh, Raisa, Veeraraghavan, Padmasree, Cochran, Craig, Klubo-Gwiezdzinska, Joanna, Gubbi, Sriram“…But once TSHA diagnosis is established, due to the risk of tumor growth leading to symptomatic SH or mass effects, active surveillance is warranted. …”
Publicado 2023
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488224“…Mutations to KLHL3 decrease Na-Cl cotransporter expression in the distal convoluted tubule leading to increased sodium and chloride reabsorption, volume expansion, hypertension, and, therefore, less sodium available for potassium exchange in the collecting duct. …”
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488225“…In the reported cases, we believe that renal failure from various causes precipitated MALA due to decrease metformin clearance, with ketosis caused by starvation and exacerbated by metformin-induced inhibition of hepatic gluconeogenesis, further aggravated by an increase in stress hormones resulting in increased insulin resistance and ultimately leading to the development of the severe ketoacidosis. …”
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488226por Hiligsmann, Mickael, Silverman, Stuart, Singer, Andrea J, Pearman, Leny, Wang, Yamei, Caminis, John N, Reginster, Jean-Yves“…Treating US men and women at very high fracture risk with sequential ABL/ALN leads to an efficient resource allocation. Presentation: Friday, June 16, 2023…”
Publicado 2023
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488227por Kim, Yoo Hyung, Wang, Injae, Jung, Jin Woo, Cheon, Seongmin, Cho, Sun Wook, Han, Dohyun, Park, Young Joo“…Park: None. BackgroundCurrent leading-edgemolecular tests of thyroid nodule/cancer were based on DNA mutation/fusionprofile, and/or the expression profiles of mRNA and miRNA. …”
Publicado 2023
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488228por Batista, Rafael Loch, Ramos, Raquel M, Afonso, Ana Caroline F, Petroli, Reginaldo J, Nishi, Mirian Yumie, Martins Ferrari, Maria Tereza, Domenice, Sorahia, Mendonca, Berenice Bilharinho“…However, small NFS indels at small triplet runs can slightly compromise AR function leading to the mild phenotype. Homopolymer runs, and trinucleotide repeats are exonic regions at risk for indels. …”
Publicado 2023
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488229“…This may suggest the presence of an unknown mutation or pathway leading to this unusual manifestation in MTC. Conclusion: In a patient with known MTC, skin lesions especially on scalp should raise suspicion for metastatic and aggressive MTC. …”
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488230por Chuki, Elias, Raffeld, Mark, Klubo-Gwiezdzinska, Joanna, Gubbi, Sriram, Jha, Smita“…The two MEN1 variants were in trans to each other on opposite alleles, suggestive of a second-hit leading to a loss of biallelic function of MEN1.Conclusion: PTC in MEN1 has been rarely reported in the literature [1]. …”
Publicado 2023
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488231por Kira, Dina, Hawkins, Zoe A, Chorich, Lynn Parson, Brakta, Soumia, Gan, Lin, Layman, Lawrence Clarke“…A 1 base deletion was introduced in exon 2, creating a frameshift and a stop codon in exon 3, which leads to a truncated protein. We then crossed male and female Znhit3(+/-) mice and Znhit3(+/-) and wild-type Znhit3(+/+) (WT) mice. …”
Publicado 2023
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488232por Alshantti, Raeda, Musurakis, Clio, Rafat, Ummara, Akhter, Wajeeha, Gilden, Janice L, Moid, Alvia“…This impairs beta-oxidation and breakdown of very long chain fatty acids (VLCFAs) which then accumulate in the CNS, adrenal cortex, and Leydig cells of the testes, leading to three main phenotypes of X-ALD: childhood cerebral ALD, adrenomyeloneuropathy AMN, and adrenal insufficiency (AI). …”
Publicado 2023
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488233“…BACKGROUND: India has witnessed rapid urbanization in recent decades, leading to a worrisome surge in non-communicable diseases, particularly overweight/obesity, which now present a critical public health concern. …”
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488234“…Using transgenic human amyloid precursor protein (hAPP)-overexpressing mice (Tg2576), we previously showed that Aβ triggers P-gp loss by activating the ubiquitin–proteasome pathway, which leads to P-gp degradation. Furthermore, we showed that inhibiting the ubiquitin-activating enzyme (E1) prevents P-gp loss and lowers Aβ accumulation in the brain of hAPP mice. …”
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488235por Jeon, Sookyoung, Scorletti, Eleonora, Dempsey, Joseph, Buyco, Delfin, Lin, Chelsea, Saiman, Yedidya, Bayen, Susovon, Harkin, Julia, Martin, Jasmin, Hooks, Royce, Ogretmen, Besim, Argemi, Josepmaria, Melo, Luma, Bataller, Ramon, Carr, Rotonya M.“…OBJECTIVE: Alcohol-associated liver disease (ALD) is the leading cause of liver-related mortality worldwide. …”
Publicado 2023
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488236por Ma, Yongcai, Su, Zeliang, Chen, Fang, Xu, Chao, Jiang, Kunsheng, An, Wenqiang, Zhang, Guanrong, Xie, Dizhi, Wang, Shuqi, Dong, Yewei, Li, Yuanyou“…Taken together, these results indicated that the CP80 diet had better amino acid composition and relatively low content of anti-nutritional factors, as well as high-digestion rate, and thus leads to the fish fed CP80 displaying improved effects in digestive enzyme activity, immune response, protein metabolism, and intestinal microbiota composition, which may be the important reasons to explain why that 80% of FM can be replaced by Cpro in the diet of golden pompano.…”
Publicado 2023
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488237por Shore, Neal D., Mehlhaff, Bryan A., Cookson, Michael S., Saltzstein, Daniel R., Tutrone, Ronald, Brown, Bruce, Lu, Sophia, Fallick, Mark, Hanson, Sarah, Saad, Fred“…INTRODUCTION: Cardiovascular (CV) events are the leading cause of death in prostate cancer. Men with prostate cancer are likely to have CV risk factors and use CV-related concomitant medications. …”
Publicado 2023
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488238por Lyles, Emily, Paik, Kenneth, Kiogora, John, Hussein, Husna, Cordero Morales, Alejandra, Kiapi, Lilian, Doocy, Shannon“…BACKGROUND: Noncommunicable disease (NCD) prevention and control in humanitarian emergencies is a well-recognized need, but there is little evidence to guide responses, leading to varying care delivery. The Sana.NCD mobile health (mHealth) app, initially developed in Lebanon, is the only known mHealth tool for NCD management designed to increase care quality and coverage for providers in humanitarian settings. …”
Publicado 2023
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488239por Song, Yu P., Tang, Man F., Leung, Agnes S. Y., Tao, Kin P., Chan, Oi M., Wong, Gary W. K., Chan, Paul K. S., Chan, Renee W. Y., Leung, Ting F.“…Rhinovirus (RV) is the leading pathogen causing childhood wheezing, with rhinovirus C (RV-C) species reported to cause asthma exacerbation. …”
Publicado 2023
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488240por Sadler, Sean, Gerrard, James, Searle, Angela, Lanting, Sean, West, Matthew, Wilson, Rhonda, Ginige, Athula, Fang, Kerry Y, Chuter, Vivienne“…However, factors such as a lack of access to culturally safe care, geographical remoteness, and high costs associated with in-person care are key barriers for First Nations Peoples in accessing evidence-based care, leading to the development of innovative mobile health (mHealth) apps as a way to increase access to health services and improve knowledge and self-care management for people with diabetes. …”
Publicado 2023
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