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488341“…Unintended pregnancy increases health risks for mother and child, leads to high economic costs for society, and increases social disparities. …”
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488342por Woelk, Godfrey B., Kieffer, Mary Pat, Walker, Damilola, Mpofu, Daphne, Machekano, Rhoderick“…Strengthens of the study are that it tests multilevel interventions, utilizes program as well as study specific and individual data, and it is conducted under “real conditions” leading to more robust findings. Limitations of the protocol include the lack of a true control arm and inadequate control for the potential effect of Option B(+), such as the intensification of messages as the importance of early ANC and male partner testing. …”
Publicado 2016
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488343“…Ablation of CAPN3 (calpain-3 knockout (C3KO) mice) leads to reduced ryanodine receptor (RyR1) expression and abnormal Ca2+/calmodulin-dependent protein kinase II (Ca-CaMKII)-mediated signaling. …”
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488344por Choi, Seung Hoan, Ruggiero, Daniela, Sorice, Rossella, Song, Ci, Nutile, Teresa, Vernon Smith, Albert, Concas, Maria Pina, Traglia, Michela, Barbieri, Caterina, Ndiaye, Ndeye Coumba, Stathopoulou, Maria G., Lagou, Vasiliki, Maestrale, Giovanni Battista, Sala, Cinzia, Debette, Stephanie, Kovacs, Peter, Lind, Lars, Lamont, John, Fitzgerald, Peter, Tönjes, Anke, Gudnason, Vilmundur, Toniolo, Daniela, Pirastu, Mario, Bellenguez, Celine, Vasan, Ramachandran S., Ingelsson, Erik, Leutenegger, Anne-Louise, Johnson, Andrew D., DeStefano, Anita L., Visvikis-Siest, Sophie, Seshadri, Sudha, Ciullo, Marina“…Four were novel loci (5q14.3, 10q21.3, 16q24.2 and 18q22.3) and the leading variants at these loci were rs114694170 (MEF2C, P = 6.79x10(-13)), rs74506613 (JMJD1C, P = 1.17x10(-19)), rs4782371 (ZFPM1, P = 1.59x10(-9)) and rs2639990 (ZADH2, P = 1.72x10(-8)), respectively. …”
Publicado 2016
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488345“…The direct [2 + 2] addition pathways leading to the formations of metalla-2-oxetane-3-one and metalla-2,4-dioxolane is thermodynamically the most favored for the ligands L = OCH(3) and Cl(−). …”
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488346por Kimura, Dai, Saravia, Jordy, Rovnaghi, Cynthia R., Meduri, Gianfranco Umberto, Schwingshackl, Andreas, Cormier, Stephania A., Anand, Kanwaljeet J.“…OBJECTIVE: Lung injury activates multiple pro-inflammatory pathways, including neutrophils, epithelial, and endothelial injury, and coagulation factors leading to acute respiratory distress syndrome (ARDS). …”
Publicado 2016
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488347por Goyal, Shivani, Morita, Plinio P, Picton, Peter, Seto, Emily, Zbib, Ahmad, Cafazzo, Joseph A“…BACKGROUND: Lifestyle behavior modification can reduce the risk of cardiovascular disease, one of the leading causes of death worldwide, by up to 80%. We hypothesized that a dynamic risk assessment and behavior change tool delivered as a mobile app, hosted by a reputable nonprofit organization, would promote uptake among community members. …”
Publicado 2016
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488348por Fan, Wenqiang, Zhao, Mengyao, Li, Suxin, Bai, Xue, Li, Jia, Meng, Haowei, Mu, Zixin“…It appears that core ABA signaling components perform their osmotic/dehydration stress response functions in a stress intensity-, duration-, species-, organ-, and isoform-specific manner, leading to plasticity in response to adverse conditions and, thus, acclimation to life on land. …”
Publicado 2016
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488349por Hale, Timothy M, Jethwani, Kamal, Kandola, Manjinder Singh, Saldana, Fidencio, Kvedar, Joseph C“…BACKGROUND: Heart failure (HF) is a chronic condition affecting nearly 5.7 million Americans and is a leading cause of morbidity and mortality. With an aging population, the cost associated with managing HF is expected to more than double from US $31 billion in 2012 to US $70 billion by 2030. …”
Publicado 2016
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488350por Mook, William R., Petri, Maximilian, Greenspoon, Joshua A., Horan, Marilee P., Millett, Peter J.“…CONCLUSION: The Latarjet procedure for recurrent shoulder instability due to glenoid bone loss reliably improves patient reported functional outcomes and leads to high levels of patient satisfaction. Workman's compensation claims were highly associated with continued instability and patients with higher preoperative pain levels were associated with inferior functional outcomes. …”
Publicado 2015
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488351Biomechanical Evaluation of Human Allograft Compression in Anterior Cruciate Ligament Reconstruction“…INTRODUCTION: A common problem encountered during ACL reconstruction is asymmetry of proximal-distal graft diameter leading to tunnel upsizing and potential graft-tunnel mismatch. …”
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488352por Wang, Tiehui, Johansson, Petronella, Abós, Beatriz, Holt, Amy, Tafalla, Carolina, Jiang, Youshen, Wang, Alex, Xu, Qiaoqing, Qi, Zhitao, Huang, Wenshu, Costa, Maria M., Diaz-Rosales, Patricia, Holland, Jason W., Secombes, Christopher J.“…Through interrogation of the recently released salmonid genomes, species in which an additional whole genome duplication event has occurred, four genomic IL-4/13 loci have been identified leading to the cloning of three active genes, IL-4/13A, IL-4/13B1 and IL-4/13B2, in both rainbow trout and Atlantic salmon. …”
Publicado 2016
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488353por Yerramsetty, Pradeep, Stata, Matt, Siford, Rebecca, Sage, Tammy L., Sage, Rowan F., Wong, Gane Ka-Shu, Albert, Victor A., Berry, James O.“…RLSB-like sequences were not identified in any other algae, suggesting that it may be specific to the evolutionary line leading to land plants. The RLSB family occurs in single copy across most angiosperms, although a few species with two copies were identified, seemingly randomly distributed throughout the various taxa, although perhaps correlating in some cases with known ancient whole genome duplications. …”
Publicado 2016
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488354“…Description: Among the two leading causes of death in the United States, each responsible for one in every four deaths, heart disease costs Americans $300 billion, while cancer costs Americans $216 billion per year. …”
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488355por Liu, Shuzheng, Chen, Qiong, Quan, Peiliang, Zhang, Meng, Zhang, Shaokai, Guo, Lanwei, Sun, Xibin, Wang, Chengzeng“…Lung cancer, stomach cancer, esophageal cancer, liver cancer, colorectal cancer, female breast cancer, brain cancer, leukemia, pancreatic cancer and cervix cancer were the leading causes of cancer deaths, accounting for about 88.50% of all cancer deaths. …”
Publicado 2016
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488356por Banerjee, Ena Ray“…RESULTS: We noticed a pattern of cellular traffic between bone marrow (BM)→ peripheral blood (PB) → lung parenchyma (LP) → (BALf) in terms of cellular recruitment of key cell sub-types critical for onset and development of the diseases which is different for maintenance and exacerbations in chronic cyclically occurring asthma that leads to airway remodelling. While inflammation is the central theme of this particular disease, degeneration and shift in cellular profile, subtly modifying the clinical nature of the disease were also noted. …”
Publicado 2015
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488357por Dinov, Ivo D., Heavner, Ben, Tang, Ming, Glusman, Gustavo, Chard, Kyle, Darcy, Mike, Madduri, Ravi, Pa, Judy, Spino, Cathie, Kesselman, Carl, Foster, Ian, Deutsch, Eric W., Price, Nathan D., Van Horn, John D., Ames, Joseph, Clark, Kristi, Hood, Leroy, Hampstead, Benjamin M., Dauer, William, Toga, Arthur W.“…This enables joint modeling of the complete data, leading to the development of Big Data analytics, predictive synthesis, and statistical validation. …”
Publicado 2016
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488358por Zar, Heather J, Barnett, Whitney, Stadler, Attie, Gardner-Lubbe, Sugnet, Myer, Landon, Nicol, Mark P“…BACKGROUND: Pneumonia is a leading cause of mortality and morbidity in children globally. …”
Publicado 2016
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488359“…BACKGROUND: Smoking remains the leading cause of preventable disease and death in the United States. …”
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488360por Zhao, Kang, Wang, Xi, Cha, Sarah, Cohn, Amy M, Papandonatos, George D, Amato, Michael S, Pearson, Jennifer L, Graham, Amanda L“…CONCLUSIONS: A multirelational approach revealed insights that could not be obtained by analyzing the aggregated network alone, such as the ineffectiveness of group discussions in triggering social ties of other types, the advantage of blogs, message boards, and private messages in leading to subsequent social ties of other types, and the weak connection between one’s centrality in the group discussion subnetwork and smoking abstinence. …”
Publicado 2016
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