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  1. 488381
    “…BACKGROUND: Acute coronary syndrome, including acute myocardial infarction (AMI), is one of the leading causes for hospitalization, with AMI 30-day readmission rates around 20%. …”
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    The Use of Text Messaging to Improve the Hospital-to-Community Transition in Acute Coronary Syndrome Patients (Txt2Prevent): Intervention Development and Pilot Randomized Controlled Trial Protocol
  2. 488382
    “…Transfection of miR-371b-5p mimic into hiPSC-ATIICs leads to significantly decreased expression of endogenous PTEN, which stimulates phosphorylation of Akt and its downstream substrates, GSK3β and FOXOs, promoting cell proliferation. …”
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    Exosome miR-371b-5p promotes proliferation of lung alveolar progenitor type II cells by using PTEN to orchestrate the PI3K/Akt signaling
  3. 488383
    “…Objectives To examine the association between intelligence measured in childhood and leading causes of death in men and women over the life course. …”
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    Childhood intelligence in relation to major causes of death in 68 year follow-up: prospective population study
  4. 488384
    por Wang, Xin, Sun, Yuan, Wang, Li, Hao, Xuelian
    Publicado 2017
    “…The present meta-analysis exists some limitations that should be noted: (1) Only five articles were included in present meta-analysis, although all of them are recently published RCTs, the sample size are relatively small; (2) Functional outcome is an important parameter, due to the insufficiency of relevant data, we cannot perform a meta-analysis. (3) Dose and types of local anesthetics are varied, which may influence the results; (4) The duration of follow up is relatively short which leads to underestimating complications. (5) Publication bias in present meta-analysis may influence the results.…”
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    Femoral nerve block versus fascia iliaca block for pain control in total knee and hip arthroplasty: A meta-analysis from randomized controlled trials
  5. 488385
    “…Most reviews conducted one or more meta-analyses (73%). Among the 25 leading causes of death globally, the Review Groups associated with the largest number of causes were: 1) Infectious Diseases, 2) Anaesthesia, Critical, and Emergency Care, 3) Injuries, 4) Pregnancy and Childbirth (PC), and 5) Neonatal. …”
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    Descriptive analysis of cochrane child-relevant systematic reviews: an update and comparison between 2009 and 2013
  6. 488386
    “…Future research should aim to determine if such intended use leads to actual use and club implementation of alcohol management policies.…”
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    The Feasibility and Acceptability of a Web-Based Alcohol Management Intervention in Community Sports Clubs: A Cross-Sectional Study
  7. 488387
    “…Ovarian cancer is the leading cause of death in women with gynecological cancers and despite recent advances, new and more efficient therapies are crucially needed. …”
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    The anti-tumor efficacy of 3C23K, a glyco-engineered humanized anti-MISRII antibody, in an ovarian cancer model is mainly mediated by engagement of immune effector cells
  8. 488388
    “…Our findings further reveal miR-500a-3p promotes the cancer stem cell characteristics via targeting multiple negative regulators of JAK/STAT3 signaling pathway, including SOCS2, SOCS4 and PTPN11, leading to constitutive activation of STAT3 signaling. …”
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    miR-500a-3p promotes cancer stem cells properties via STAT3 pathway in human hepatocellular carcinoma
  9. 488389
    “…OBJECTIVES: Current therapies for cartilage repair either do not result in regeneration of articular cartilage, or there is inadequate integration with the host tissue leading to failure of the repair. Thus, there is an interest in developing alternative approaches. …”
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    The Role of Platelet-Rich Plasma in Promoting Cartilage Integration and Chondrocyte Migration
  10. 488390
    “…Football remains the most popular and is the leading cause of sports-related injuries among high school students. …”
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    Epidemiology of Contact Injuries in High School Athletes in the United States
  11. 488391
    “…Intravascular optical coherence tomography (OCT) may provide insights into mechanistic processes leading to ST. We performed a prospective, multicenter study to evaluate OCT findings in patients with ST. …”
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    Optical Coherence Tomography Findings in Patients With Coronary Stent Thrombosis: A Report of the PRESTIGE Consortium (Prevention of Late Stent Thrombosis by an Interdisciplinary Global European Effort)
  12. 488392
    por Scheltema, Nienke M, Gentile, Angela, Lucion, Florencia, Nokes, D James, Munywoki, Patrick K, Madhi, Shabir A, Groome, Michelle J, Cohen, Cheryl, Moyes, Jocelyn, Thorburn, Kentigern, Thamthitiwat, Somsak, Oshitani, Hitoshi, Lupisan, Socorro P, Gordon, Aubree, Sánchez, José F, O'Brien, Katherine L, Gessner, Bradford D, Sutanto, Agustinus, Mejias, Asuncion, Ramilo, Octavio, Khuri-Bulos, Najwa, Halasa, Natasha, de-Paris, Fernanda, Pires, Márcia Rosane, Spaeder, Michael C, Paes, Bosco A, Simões, Eric A F, Leung, Ting F, da Costa Oliveira, Maria Tereza, de Freitas Lázaro Emediato, Carla Cecília, Bassat, Quique, Butt, Warwick, Chi, Hsin, Aamir, Uzma Bashir, Ali, Asad, Lucero, Marilla G, Fasce, Rodrigo A, Lopez, Olga, Rath, Barbara A, Polack, Fernando P, Papenburg, Jesse, Roglić, Srđan, Ito, Hisato, Goka, Edward A, Grobbee, Diederick E, Nair, Harish, Bont, Louis J
    Publicado 2017
    “…METHODS: In this retrospective case series, we developed an online questionnaire to obtain individual patient data for clinical and socioeconomic characteristics of children aged younger than 5 years who died with community-acquired RSV infection between Jan 1, 1995, and Oct 31, 2015, through leading research groups for child pneumonia identified through a comprehensive literature search and existing research networks. …”
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    Global respiratory syncytial virus-associated mortality in young children (RSV GOLD): a retrospective case series
  13. 488393
    “…It can change and improve research quality, which is crucial when answering questions that are meaningful and important to patients, and which leads to increased impact. Collaboration with patients and the public should be planned and reported from the conception of a research idea where the impact of such input can be considerable.…”
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    More than just ticking a box…how patient and public involvement improved the research design and funding application for a project to evaluate a cycling intervention for hip osteoarthritis
  14. 488394
    “…BACKGROUND: Streptococcus pneumoniae (pneumococcus) is a leading cause of a variety of diseases, including bacteremia, meningitis, and pneumonia, among older adults in the United States. …”
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    Evaluation of a 15-valent Pneumococcal Conjugate Vaccine in an Adult Rhesus Macaque Immunogenicity Model
  15. 488395
    “…BACKGROUND: Diarrhea remains a leading killer of young children on the globe despite the availability of simple and effective solutions to prevent and control it. …”
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    Childhood diarrheal morbidity and sanitation predictors in a nomadic community
  16. 488396
    “…BACKGROUND: Diarrhoea is a leading cause of child death in Zambia. As elsewhere, the disease burden could be greatly reduced through caregiver uptake of existing prevention and treatment strategies. …”
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    Disentangling the effects of a multiple behaviour change intervention for diarrhoea control in Zambia: a theory-based process evaluation
  17. 488397
    “…Taken together, mEH appears to play a leading role in the hydrolysis of 8,9-EET and 9,10-EpOME and also contributes to the hydrolysis of other FA epoxides. …”
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    Beyond detoxification: a role for mouse mEH in the hepatic metabolism of endogenous lipids
  18. 488398
    “…BACKGROUND: The number of lumbar spine surgeries has been increasing during the last 20 years, which also leads to an increase in hospital costs and complications related to surgery. …”
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    Length of stay, costs, and complications in lumbar disc herniation surgery by standard PLIF versus a new dynamic interspinous stabilization technique
  19. 488399
    “…Capsular Vi-polysaccharide-protein conjugate vaccines (Vi-conjugate vaccines) are immunogenic and can be used from infancy but there are no efficacy data for the leading candidate vaccine being considered for widespread use. …”
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    Efficacy and immunogenicity of a Vi-tetanus toxoid conjugate vaccine in the prevention of typhoid fever using a controlled human infection model of Salmonella Typhi: a randomised controlled, phase 2b trial
  20. 488400
    “…BACKGROUND: Compared with World Health Organization-defined acute myeloid leukaemia (AML) not otherwise specified, patients with AML with myelodysplasia-related changes (AML-MRC) are generally older and more likely to have poor-risk cytogenetics, leading to poor response and prognosis. More than one-half of all older (≥65 years) patients in the phase 3 AZA-AML-001 trial had newly diagnosed AML-MRC. …”
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    Azacitidine improves clinical outcomes in older patients with acute myeloid leukaemia with myelodysplasia-related changes compared with conventional care regimens
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