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  1. 488441
    “…BACKGROUND: Mental health and substance use disorders are the leading causes of global disability in children and youth. …”
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    Evaluating the Long-Term Effectiveness of School-Based Depression, Anxiety, and Substance Use Prevention Into Young Adulthood: Protocol for the Climate School Combined Study
  2. 488442
    “…BACKGROUND: Identifying bacterial coinfection in influenza patients can be difficult as the symptoms of simple influenza vs. mixed infections are often similar, leading to antibiotic overuse. A new host-response assay (ImmunoXpert™) that integrates the levels of three proteins (TRAIL, IP-10, and CRP) was shown to exhibit high performance in distinguishing between bacterial and viral disease in two double-blind validation studies. …”
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    1948. A Host-Response Assay Distinguishes Between Simple Influenza Patients and Influenza Patients With Bacterial Coinfection
  3. 488443
    “…CONCLUSION: Our results suggest that primer set amplifying the V1–V3 region of the 16S rRNA gene leads to slightly better detection results compared with the V3–V4 primer set used. …”
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    2029. Comparison of Primers Amplifying Two Different Regions of the 16S Ribosomal RNA Gene for Microbiologic Diagnosis of Cardiovascular Implantable Electronic Device Infection
  4. 488444
    “…CONCLUSION: The absence of infectious etiology in NF often leads to broad AM therapy or delay of targeted treatment. …”
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    2294. Evaluation of the Karius Plasma Next-Generation Sequencing Cell-free Pathogen DNA Test to Determine the Etiology of Infection and Impact on Anti-Microbial Management in Patients with Severe Neutropenia and Fever
  5. 488445
    “…BACKGROUND: Clostridium difficile, a spore-forming, anaerobic, Gram-positive bacterium, is the leading cause of nosocomial diarrhea. C. difficile infection (CDI) is mediated by two toxins, A (TcdA) and B (TcdB), and the role of each toxin in CDI pathogenesis remains unclear. …”
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    1093. Single Molecule Counting Technology for Ultrasensitive Quantification of Clostridium difficile Toxins A and B
  6. 488446
    “…AEs were reported in 17 (10.7%) patients; 9 (5.7%) reported a serious AE, and 12 (7.5%) had AEs leading to TLV discontinuation. A total of 7 (4.4%) renal AEs were reported; 5 (3.8%) patients discontinued due to renal AEs. …”
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    2369. Clinical Experience With Telavancin for Treatment of Patients With Monomicrobial S. aureus Infections (Vancomycin MIC ≥1 μg/mL) From TOUR™
  7. 488447
    Publicado 2019
    “…Falls and road injuries were the leading causes of new cases of TBI and SCI in most regions. …”
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    Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
  8. 488448
    “…BACKGROUND: Cigarette smoking remains the leading cause of preventable death and disease worldwide. …”
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    A Comprehensive Digital Program for Smoking Cessation: Assessing Feasibility in a Single-Group Cohort Study
  9. 488449
    “…IMPORTANCE: Hypertension is a leading cause of cardiovascular disease. The results were previously reported of a trial of home blood pressure (BP) telemonitoring and pharmacist management intervention in which the interventions stopped after 12 months. …”
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    Long-term Outcomes of the Effects of Home Blood Pressure Telemonitoring and Pharmacist Management on Blood Pressure Among Adults With Uncontrolled Hypertension: Follow-up of a Cluster Randomized Clinical Trial
  10. 488450
    “…More importantly, loss of function studies using antagomiRs showed that forced inhibition of miR-643 leads to restoration of XIAP levels and suppression of both apoptosis and caspases-3 and -9 activation. …”
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    Entamoeba histolytica Up-Regulates MicroRNA-643 to Promote Apoptosis by Targeting XIAP in Human Epithelial Colon Cells
  11. 488451
    “…Despite recent improvement in adjuvant therapies, triple-negative, and ER(+) subtypes of breast cancer (BC) with metastatic potentials remain the leading cause of BC-related deaths. We investigated the role of phosphatidylinositol-4-phosphate 5-kinase alpha (PIP5Kα), a key upstream factor of PI3K/AKT, and the therapeutic effect of PIP5Kα inhibitor on subtypes of BC. …”
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    The role of PIP5K1α/pAKT and targeted inhibition of growth of subtypes of breast cancer using PIP5K1α inhibitor
  12. 488452
    “…CONCLUSIONS: Our study, using genetic variants as instrumental variables for BMI, provides evidence that higher BMI leads to a higher risk of psoriasis. This supports the prioritization of therapies and lifestyle interventions aimed at controlling weight for the prevention or treatment of this common skin disease. …”
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    Evidence of a causal relationship between body mass index and psoriasis: A mendelian randomization study
  13. 488453
    “…Imbalance between insulin vascular actions via the phosphatidylinositol 3-Kinase (PI3K) and the mitogen activated protein kinase (MAPK) signaling pathways during insulin resistant states results in impaired endothelial PI3K/eNOS- and augmented MAPK/endothelin 1 pathways leading to endothelial dysfunction and abnormal vasoconstriction. …”
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    Role of Phosphatidylinositol 3-Kinase (PI3K), Mitogen-Activated Protein Kinase (MAPK), and Protein Kinase C (PKC) in Calcium Signaling Pathways Linked to the α(1)-Adrenoceptor in Resistance Arteries
  14. 488454
    “…BACKGROUND: Peripheral artery disease (PAD), the third leading cause of atherosclerotic vascular morbidity, affects approximately 202 million people worldwide, among whom more than two-thirds reside in low- and middle-income countries (LMIC). …”
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    National and subnational estimation of the prevalence of peripheral artery disease (PAD) in China: a systematic review and meta-analysis
  15. 488455
    “…In Canada, most VAI care is provided by family, leading to poor health-related quality of life and increased caregiver burden. …”
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    Development of a Web-Based Peer Support Program for Family Caregivers of Ventilator-Assisted Individuals Living in the Community: Protocol for a Pilot Randomized Controlled Trial
  16. 488456
    “…However, the impact of these tools has been limited by low provider adoption due to overtriggering, leading to alert fatigue. We developed a tracking mechanism for monitoring trigger (percent of total visits for which the tool triggers) and adoption (percent of completed tools) rates of a complex CDS tool based on the Wells criteria for pulmonary embolism (PE). …”
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    Improving Provider Adoption With Adaptive Clinical Decision Support Surveillance: An Observational Study
  17. 488457
    por Hasegawa, Masatoshi
    Publicado 2017
    “…The system derived from 3,3′,4,4′-biphenyltetracarboxylic dianhydride (s-BPDA) and t-CHDA can be polymerized by a controlled heating method and leads to a PI film with relatively good properties, i.e., excellent light transmittance at 400 nm (T(400) = ~80%), a high T(g) (>300 °C), and a very low CTE (10 ppm·K(−1)). …”
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    Development of Solution-Processable, Optically Transparent Polyimides with Ultra-Low Linear Coefficients of Thermal Expansion
  18. 488458
    “…AIMS/HYPOTHESIS: Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a circulatory macrophage-derived factor that increases with obesity and leads to a higher risk of cardiovascular disease (CVD). …”
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    Differential expression of Lp-PLA2 in obesity and type 2 diabetes and the influence of lipids
  19. 488459
    por Ziedan, Ahmed, Bhandari, Sunil
    Publicado 2019
    “…We hypothesize that IV iron leads to changes in oxidative stress, endothelial function, and potential renal damage depending on the iron formulation (related to the generation of “free” or catalytic labile iron) and this may result in more tubular and glomerular injury manifested as increased proteinuria and raised neutrophil gelatinase–associated lipocalin (NGAL) levels in patients with chronic kidney disease (CKD). …”
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    Protocol and baseline data for a prospective open-label explorative randomized single-center comparative study to determine the effects of various intravenous iron preparations on markers of oxidative stress and kidney injury in chronic kidney disease (IRON-CKD)
  20. 488460
    “…We suggest that the government’s leading role and collective collaboration with health care organizations are important for providing effective health information exchanges.…”
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    An Assessment of the Interoperability of Electronic Health Record Exchanges Among Hospitals and Clinics in Taiwan
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