“…The bidirectional nature of this relationship leads to the figuration of an intriguing vicious circle where T deficiency triggers the onset of comorbidities or, vice versa, poor health status induces hypogonadism. …”
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“…We hypothesized that CNC leads to renal formation of cysts in humans, with increased number of renal cysts and earlier age at detection. 117 patients with CNC (69 female [59%], 48 male [41%]) were evaluated with renal imaging (56% MRI, 41% CT, 3% US). …”
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“…It is characterized by significantly elevated parathyroid hormone (PTH) levels even up to 20 times above the normal limit along with calcium levels >15 mg/dl, leading to multiorgan dysfunction, notably altered mental status and acute kidney injury. …”
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“…High doses of calcium from antacids can bind phosphate in the gut, leading to poor phosphate absorption and hypophosphatemia. …”
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“…We hypothesized that increased Gαs protein levels in osteoblasts outcompete β-arr binding to PTH1R, leading to reduced signal termination and increased bone formation. …”
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“…Background: Glycogen storage disease type 1b (GSD1b) is caused by a deficiency of glucose 6 phosphatase leading to glycogen deposition. The hallmark findings of GSD1b are hypoglycemia and lactic acidosis. …”
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“…In this case, the decrease of TSH due to hyperthyroidism was considered to reduce hepatic PCSK9 expression, leading to additive effect to PCSK9 inhibitor. PCSK9 inhibitors may modify the effects of hyperlipidemia treatment by causing changes in thyroid function. …”
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“…DLK1/MEG3:IG-DMR hypomethylation was identified in 3 patients with CPP and additional findings of Temple syndrome, indicating that loss of effective imprinting of DLK1 locus is a mechanism leading to CPP.…”
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“…OBJECTIVE: This study examined user engagement with and feedback on a theory-grounded SMS text messaging intervention intended to prevent perceived insufficient milk (PIM)—the single, leading modifiable cause of unintended breastfeeding reduction and cessation. …”
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“…Repetitive movement through sport specialization has been hypothesized to increase the stress through the lower extremity, leading to injury. However, the underlying mechanism is unclear. …”
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“…Accordingly, clinical voice hearers may have problems differentiating between self-initiated and externally generated speech, potentially leading to externalization of their own speech. In line with this proposal, the current study focusses on non-clinical aspects of the psychosis continuum in healthy voice hearers and controls. …”
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“…BACKGROUND: Vocational drift, or the suggestion that severe mental illness leads to reductions in occupational attainment, has been repeatedly observed in schizophrenia. …”
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“…BACKGROUND: Childhood maltreatment (CM) is a major psychiatric risk factor and leads to long-lasting physical and mental health implications throughout the affected individual’s lifespan. …”
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“…In NMDAR encephalitis (NMDARE), which holds clinical similarities with schizophrenia, autoantibodies target NMDARs, predominantly located in the hippocampal region, leading to disrupted glutamatergic transmission. One study so far has described abnormal connectivity between the medial temporal lobe and posterior default mode network regions in patients with NMDARE (Peer et al., 2017), however no study so far has examined brain functional correlates of schizophrenia and NMDARE comparatively. …”
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“…This suggests that the proteome-wide decrease in S-acylated proteins in schizophrenia is caused by another mechanism, possibly increased expression or function of one or more of the specific PATs, leading to substrate specific changes in S-acylation, or a decrease in activity the acyl protein transferase enzymes, which attach acyl groups to proteins.…”
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“…Analyzing the contribution of individual predictor variables showed that GAF functional decline, a family history of psychosis, and performance on the Hopkins Verbal Learning Test were the most influential clinical predictors, whereas modular connectome organization, default-mode and fronto-parietal within-network connectivity, and between-network connectivity among language, salience, dorsal attention, cerebellum, and sensorimotor networks were the leading fMRI predictors. DISCUSSION: This study’s findings suggest that functional brain abnormalities reflected by alterations in resting-state functional connectivity precede and may drive subsequent changes in clinical functioning. …”
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“…When transplanted under the left renal capsule of SCID-Beige diabetic mice, these IPCs reversed hyperglycemia, leading to a significant increase in the definitive endoderm cells. …”
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“…LTE appears to offer a protective effect, with exposure to program messages leading to reduced/improved drug use intentions.…”
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“…Patients affected by severe coronavirus induced disease-2019 (Covid-19) often experience hypoxemia due to alveolar involvement and endothelial dysfunction, which leads to the formation of micro thrombi in the pulmonary capillary vessels. …”
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“…OBJECTIVES: To confirm that structured reporting of CT scans using ten signs in clinical practice leads to a better accuracy in diagnosing internal herniation (IH) after gastric bypass surgery, compared with free-text reporting. …”
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