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  1. 488841
    “…IMPORTANCE Sepsis is the third leading cause of mortality in Western countries and one of the Global Health Threats recognized by the WHO since 2017. …”
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    A 21-Year Survey of Escherichia coli from Bloodstream Infections (BSI) in a Tertiary Hospital Reveals How Community-Hospital Dynamics of B2 Phylogroup Clones Influence Local BSI Rates
  2. 488842
    “…BACKGROUND: Tumor-associated macrophages (TAMs) have a leading position in the tumor microenvironment. Previously, we have demonstrated that M1-like TAMs activated by exosome-transferred THBS1 promote malignant migration in oral squamous cell carcinoma (OSCC). …”
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    M1-like tumor-associated macrophages cascade a mesenchymal/stem-like phenotype of oral squamous cell carcinoma via the IL6/Stat3/THBS1 feedback loop
  3. 488843
    “…It is especially so in the low- and middle-income settings where possible context-specific aetiologies leading to anaemia have been poorly explored. This study explores the prevalence of etiological factors significantly contributing to anaemia in pregnancy in Sri Lanka, a lower-middle-income country with a high prevalence of malnutrition albeit robust public health infrastructure. …”
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    Prevalence and aetiologies of anaemia among first trimester pregnant women in Sri Lanka; the need for revisiting the current control strategies
  4. 488844
    “…METHODS: Heart rate (HR) and velocity during on-water training of nine highly trained German sprint kayakers were recorded during the final 8 weeks of a competition period leading to the national championships. The fractional analysis of TID was based on three zones (Z) derived from either HR (TID(Bla-HR)) or velocity (TID(Bla-V)) based on blood lactate (B(la)) concentrations (Z1 ≤ 2.5 mmol L(−1) B(la), Z2 = 2.5–4.0 mmol L(−1) B(la), Z3 ≥ 4.0 mmol L(−1) B(la)) of an incremental test or the 1000-m race pace (TID(Race)): Z1 ≤ 85% of race pace, Z2 = 86–95% and Z3 ≥ 95%. …”
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    Retrospective Analysis of Training Intensity Distribution Based on Race Pace Versus Physiological Benchmarks in Highly Trained Sprint Kayakers
  5. 488845
    “…Tuberculosis was the leading specific COD identified, particularly soon after enrolment, while in later calendar years cardiovascular and renal causes emerged as important, emphasising the need for improved screening and management. …”
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    Causes of death and associated factors over a decade of follow-up in a cohort of people living with HIV in rural Tanzania
  6. 488846
    “…BACKGROUND: Pneumonia is the leading infectious cause of death in children aged under 5 years in low- and middle-income countries (LMICs). …”
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    Chest radiography in children aged 2–59 months enrolled in the Innovative Treatments in Pneumonia (ITIP) project in Lilongwe Malawi: a secondary analysis
  7. 488847
    “…The anthropogenic entry of organic micropollutants into the aquatic environment leads to a potential risk for drinking water resources and the drinking water itself. …”
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    Target, suspect and non-target screening analysis from wastewater treatment plant effluents to drinking water using collision cross section values as additional identification criterion
  8. 488848
    por Mauro, Francesca Romana, Paoloni, Francesca, Molica, Stefano, Reda, Gianluigi, Trentin, Livio, Sportoletti, Paolo, Marchetti, Monia, Pietrasanta, Daniela, Marasca, Roberto, Gaidano, Gianluca, Coscia, Marta, Stelitano, Caterina, Mannina, Donato, Di Renzo, Nicola, Ilariucci, Fiorella, Liberati, Anna Marina, Orsucci, Lorella, Re, Francesca, Tani, Monica, Musuraca, Gerardo, Gottardi, Daniela, Zinzani, Pier Luigi, Gozzetti, Alessandro, Molinari, Annalia, Gentile, Massimo, Chiarenza, Annalisa, Laurenti, Luca, Varettoni, Marzia, Ibatici, Adalberto, Murru, Roberta, Ruocco, Valeria, Del Giudice, Ilaria, De Propris, Maria Stefania, Della Starza, Irene, Raponi, Sara, Nanni, Mauro, Fazi, Paola, Neri, Antonino, Guarini, Anna, Rigolin, Gian Matteo, Piciocchi, Alfonso, Cuneo, Antonio, Foà, Robin
    Publicado 2021
    “…The 48-month cumulative rates of treatment discontinuations due to disease progression (DP) or adverse events (AEs) were 5.6% and 29.1%, respectively. AEs leading more frequently to treatment discontinuation were atrial fibrillation in 8% of patients, infections in 8%, and non-skin cancers in 6%. …”
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    Efficacy of Front-Line Ibrutinib and Rituximab Combination and the Impact of Treatment Discontinuation in Unfit Patients with Chronic Lymphocytic Leukemia: Results of the Gimema LLC1114 Study
  9. 488849
    “…We validated the results using the CAFA 3 benchmark platform for GO annotation, finding that out of the multiple association metrics and domain datasets tested, Simpson index for FunFam domain-function associations combined with Stouffer’s method leads to the best performance in almost all scenarios. …”
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    Assigning protein function from domain-function associations using DomFun
  10. 488850
    “…RESULTS: From 225 patients discharged from March to November 2020 we excluded 12 incomplete/missing cases, and 13 unable to perform CPET leading to a final population of 200 patients. At PFT all median parameters were within normality range. …”
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    Cardiopulmonary exercise testing in COVID-19 patients at 3 months follow-up
  11. 488851
    “…BACKGROUND: Despite improvements in disease diagnosis, treatment, and prognosis, breast cancer is still a leading cause of cancer death for women. Compelling evidence suggests that targeting cancer stem cells (CSCs) have a crucial impact on overcoming the current shortcomings of chemotherapy and radiotherapy. …”
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    Interferon-gamma inhibits aldehyde dehydrogenase(bright) cancer stem cells in the 4T1 mouse model of breast cancer
  12. 488852
    “…In radioembolization, microbeads conjugated to a radioactive drug are injected into the blood vessels, nourishing the cancers and leading to cell death and tumor shrinkage. In this study, we retrospectively analyzed 35 patients with liver sarcomas receiving radioembolization at our institution. …”
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    Efficacy and Safety of Trans-Arterial Yttrium-90 Radioembolization in Patients with Unresectable Liver-Dominant Metastatic or Primary Hepatic Soft Tissue Sarcomas
  13. 488853
    “…BACKGROUND: Human respiratory syncytial virus (HRSV) is the leading pathogens causing acute respiratory infections (ARI) in children under five years old. …”
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    Rapid typing diagnosis and clinical analysis of subtypes A and B of human respiratory syncytial virus in children
  14. 488854
    “…BACKGROUND: Recent studies highlighted the biosynthetic potential of nocardiae to produce diverse novel natural products comparable to that of Streptomyces, thereby making them an attractive source of new drug leads. Many of the 119 Nocardia validly named species were isolated from natural habitats but little is known about the diversity and the potential of the endophytic nocardiae of root nodule of actinorhizal plants. …”
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    Genome insights into the pharmaceutical and plant growth promoting features of the novel species Nocardia alni sp. nov
  15. 488855
    “…OBJECTIVE: To compare the clinical consequences of incident severe CKD and the first diagnosis with a malignant tumor, focusing on the 10 leading causes of cancer in men and women residing in Canada. …”
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    Mortality and Resource Use Among Individuals With Chronic Kidney Disease or Cancer in Alberta, Canada, 2004-2015
  16. 488856
    “…BACKGROUND: Cardiovascular diseases (CVDs) are the leading cause of death worldwide and are increasingly affecting younger populations, particularly African Americans in the southern United States. …”
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    An Open-Source Privacy-Preserving Large-Scale Mobile Framework for Cardiovascular Health Monitoring and Intervention Planning With an Urban African American Population of Young Adults: User-Centered Design Approach
  17. 488857
    “…Conventional methods consist of arthroscopic debridement and bone marrow stimulation techniques including microfracture, curettage, abrasion chondroplasty and antegrade/retrograde drilling predominantly leading to fibrocartilage formation. These methods have proved effective for small lesions; however, larger lesions with accompanying subchondral bone cysts require more invasive treatment with osteochondral allografts or autologous chondrocyte implantation. …”
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    Arthroscopically Assisted Particulated Juvenile Allograft Cartilage Implantation and Bone Grafting for Treatment of Large Cystic Osteochondral Lesions of the Talus: A Case Series
  18. 488858
    “…CATEGORY: Bunion; Midfoot/Forefoot INTRODUCTION/PURPOSE: Psychiatric comorbidity has been shown to significantly impact postoperative course, leading to increasingly complicated hospitalizations, increased pain, and worse overall patient outcomes. …”
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    Improvement of Depressive Symptoms Following Surgical Correction of Hallux Valgus and Hallux Rigidus via 1st MTP Fusion
  19. 488859
    “…When graded with WBCT, the subchondral cyst in the proximal phalanx and metatarsal head were better delineated leading to higher grade in WBCT. Further studies are needed for inter-rater reliability and discriminant validity of the measurements determined by differences between different groups (HR vs control).…”
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    Comparative Assessment of Hallux Rigidus using Conventional Radiograph and Weightbearing CT
  20. 488860
    “…About 80% of ankle OA is believed to be post-traumatic and affects the younger population leading to a higher risk of disabilities during life. …”
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    Conditioned Medium of Mesenchymal Stem Cells Prevents Degenerative Changes in Ankle Osteoarthritis in Rat Models
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