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  1. 488921
    “…The rotation of development through multiple databases provides context to model assessment, leading to improved understanding of transportability and generalizability. …”
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    Using Iterative Pairwise External Validation to Contextualize Prediction Model Performance: A Use Case Predicting 1-Year Heart Failure Risk in Patients with Diabetes Across Five Data Sources
  2. 488922
    “…In striking contrast, ECM remodeling following chronic pressure overload insidiously develops over time as “reactive fibrosis” leading to diffuse interstitial and perivascular collagen deposition that continuously perturbs the function of the left (L) or the right ventricle (RV). …”
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    Cardiac Fibrosis in the Pressure Overloaded Left and Right Ventricle as a Therapeutic Target
  3. 488923
    “…Depression in patients with T2DM interferes with blood glucose management, leads to poor treatment outcomes, and has a high risk of dementia and cardiovascular event. …”
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    A Systematic Review and Meta-Analysis of the Prevalence and Risk Factors of Depression in Type 2 Diabetes Patients in China
  4. 488924
    por Kumar, Kalagi Amit
    Publicado 2022
    “…The cognitive impairment is attributed to HIV replication in the brain and liberation of inflammatory neurotoxins leading to neuronal dysfunction. The American academy of neurology task force on the acquired immune deficiency syndrome AIDS defined two level of neurological impairment in HIV patients: 1.HIV associated dementia(HAD)and 2.minor cognitive motor disorder (MCMD).A core difference between the two is the degree of functional impairment present . …”
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    Neurocognitive deficits in HIV/AIDS patients on HAART Regime
  5. 488925
    “…CONCLUSION: CMS in mice induces a pro-inflammatory microglial phenotype that causes reduced crosstalk between microglia and neuron, inflammation and synaptic dysfunction in the hippocampus, ultimately leading to depression-like behaviors. Asperosaponin VI may ameliorate the effects of CMS by inducing microglia to adopt a PPAR-γ-dependent neuroprotective phenotype. …”
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    Asperosaponin VI ameliorates the CMS-induced depressive-like behaviors by inducing a neuroprotective microglial phenotype in hippocampus via PPAR-γ pathway
  6. 488926
    “…BACKGROUND: Persistent HPV16 infection is the leading risk factor for developing cervical cancer. …”
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    Anti-L1 antibody-bound HPV16 pseudovirus is degraded intracellularly via TRIM21/proteasomal pathway
  7. 488927
    “…Diabetes is one of the 10 leading causes of death globally, and individuals with diabetes have a 2–3-fold increased risk of all-cause mortality. …”
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    Differential Association of Selected Adipocytokines, Adiponectin, Leptin, Resistin, Visfatin and Chemerin, with the Pathogenesis and Progression of Type 2 Diabetes Mellitus (T2DM) in the Asir Region of Saudi Arabia: A Case Control Study
  8. 488928
    “…However, the effects of stroke on global cognition, leading up to dementia, remain poorly understood. …”
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    Trajectories of cognitive change following stroke: stepwise decline towards dementia in the elderly
  9. 488929
    “…Identifying factors contributing to modifications may help institutions become better prepared to implement an intervention by addressing known factors in advance, which may foster greater fidelity leading to desired outcomes. TRIAL REGISTRATION: ClinicalTrials.govNCT03276390. …”
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    Implementation and modification of an organizational-level intervention: a prospective analysis
  10. 488930
    “…GRAPHICAL ABSTRACT: (Left panel) the accumulation of overexpressed PMP22 or misfolded mutant P0 in the Schwann cell endoplasmic reticulum (ER) leads to overwhelming of the degradative capacity, activation of ER-stress mechanisms, and myelination impairment. …”
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    Treatment with IFB-088 Improves Neuropathy in CMT1A and CMT1B Mice
  11. 488931
    por Kaushik, Ankita, Bhartiya, Deepa
    Publicado 2022
    “…Neonatal DES exposure affected testicular very small embryonic-like stem cells (VSELs) and spermatogonial stem cells and resulted in infertility, reduced sperm counts and tumor-like changes leading to our postulate that testicular dysgenesis syndrome possibly has a stem cell basis. …”
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    Testicular cancer in mice: interplay between stem cells and endocrine insults
  12. 488932
    “…We identified risk factors, and clinical or molecular biomarkers that could be therapeutic targets for wake-up stroke prevention, thus hopefully leading to a decrease in its mortality and disability in medium to long-term outcome. …”
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    Surrogate biomarkers of outcome for wake-up ischemic stroke
  13. 488933
    “…SIMPLE SUMMARY: The number of thoracic vertebrae (TN) and lumbar vertebrae (LN) in Dezhou donkey population is different, which leads to the difference of meat production and skin yield, and it is regulated by a few genes. …”
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    Multi-Thoracolumbar Variations and NR6A1 Gene Polymorphisms Potentially Associated with Body Size and Carcass Traits of Dezhou Donkey
  14. 488934
    “…CTB-193M12.5 bound and recruited NSD1 to the promoter of WNT10B, leading to an increase in di-methylation of histone H3 at lysine 36 (H3K36me2) and the reduction of tri-methylation of histone H3 at lysine 27 (H3K27me3) at WNT10B promoter. …”
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    CTB-193M12.5 Promotes Hepatocellular Carcinoma Progression via Enhancing NSD1-Mediated WNT10B/Wnt/β-Catenin Signaling Activation
  15. 488935
    “…Mutations to the RYR1 gene can compromise calcium homeostasis leading to a vast range of clinical phenotypes encompassing hypotonia, myalgia, respiratory insufficiency, ophthalmoplegia, fatigue and malignant hyperthermia (MH). …”
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    Identification of ER/SR resident proteins as biomarkers for ER/SR calcium depletion in skeletal muscle cells
  16. 488936
    “…BACKGROUND: Coronary artery disease (CAD) remains the leading cause of mortality worldwide despite enormous efforts devoted to its prevention and treatment. …”
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    Mendelian randomization analysis of 37 clinical factors and coronary artery disease in East Asian and European populations
  17. 488937
    “…BACKGROUND: Recent studies have demonstrated that T cells can induce vasodilation in a choline-acetyltransferase dependent manner, leading to an increase in T cell migration to infected tissues in response to viral infection, but its role in cancer is unclear. …”
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    Increase in serum choline levels predicts for improved progression-free survival (PFS) in patients with advanced cancers receiving pembrolizumab
  18. 488938
    por Nshimiyimana, Yassin, Zhou, Yingchun
    Publicado 2022
    “…Sub-Saharan Africa and South Asia account for 95% of global child mortalities every year, where acute respiratory infections (ARI) remain the leading cause of child morbidity and mortality. The aim of this study is to analyze the risk factors of ARI disease symptoms among children under the age of 5 years in Uganda. …”
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    Analysis of risk factors associated with acute respiratory infections among under-five children in Uganda
  19. 488939
    “…BACKGROUND: Type 2 diabetes mellitus (T2DM) is becoming one of the leading causes of morbidity and mortality worldwide, including among Africans. …”
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    Effect of age and sex on the associations between potential modifiable risk factors and both type 2 diabetes and impaired fasting glycaemia among West African adults
  20. 488940
    “…BACKGROUND: Pain is one of the most common, yet challenging problems leading to emergency department (ED) presentation, despite the availability of a wide range of pharmacological therapies. …”
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    Virtual Reality for Pain Relief in the Emergency Room (VIPER) – a prospective, interventional feasibility study
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