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  1. 489181
    “…RESULTS: In vitro and in vivo experiments confirmed that HR-EMVs exacerbated oxidative stress and apoptosis in IR-injured cardiomyocytes, leading to increased infarct size and worsened cardiac function. …”
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    Propofol inhibits myocardial injury induced by microvesicles derived from hypoxia-reoxygenated endothelial cells via lncCCT4-2/CCT4 signaling
  2. 489182
    “…The persistence of this inflammatory cell infiltration leads to fibrosis and organ failure. Adipose-derived mesenchymal stem cells (ASCs) have received much attention as a regenerative therapeutic tool to prevent progression from organ injury to failure. …”
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    Comparison of therapeutic effects of mesenchymal stem cells derived from superficial and deep subcutaneous adipose tissues
  3. 489183
    “…Given the fact that coronavirus infections induce cytokines secretion leading to inflammatory lung injury, it has been suggested that H-FABP levels are affected by COVID-19 severity. …”
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    Evaluation of circulating insulin-like growth factor-1, heart-type fatty acid-binding protein, and endotrophin levels as prognostic markers of COVID-19 infection severity
  4. 489184
    “…BACKGROUND: For blood-stage malaria vaccine development, the in vitro growth inhibition assay (GIA) has been widely used to evaluate functionality of vaccine-induced antibodies (Ab), and Plasmodium falciparum reticulocyte-binding protein homolog 5 (RH5) is a leading blood-stage antigen. However, precision, also called “error of assay (EoA)”, in GIA readouts and the source of EoA has not been evaluated systematically. …”
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    Assessment of precision in growth inhibition assay (GIA) using human anti-PfRH5 antibodies
  5. 489185
    “…BACKGROUND: Depression is the leading cause of global disability and can develop following the change in body image and functional capacity associated with stoma surgery. …”
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    Depression after stoma surgery: a systematic review and meta-analysis
  6. 489186
    “…BACKGROUND: Human norovirus (HuNoV) is the leading cause of acute nonbacterial gastroenteritis globally, and its infection is usually self-limited, so most people become past Norovirus (NoV)-infected individuals. …”
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    Linear epitopes on the capsid protein of norovirus commonly elicit high antibody response among past-infected individuals
  7. 489187
    por Huerta-Chagoya, Alicia, Schroeder, Philip, Mandla, Ravi, Deutsch, Aaron J., Zhu, Wanying, Petty, Lauren, Yi, Xiaoyan, Cole, Joanne B., Udler, Miriam S., Dornbos, Peter, Porneala, Bianca, DiCorpo, Daniel, Liu, Ching-Ti, Li, Josephine H., Szczerbiński, Lukasz, Kaur, Varinderpal, Kim, Joohyun, Lu, Yingchang, Martin, Alicia, Eizirik, Decio L., Marchetti, Piero, Marselli, Lorella, Chen, Ling, Srinivasan, Shylaja, Todd, Jennifer, Flannick, Jason, Gubitosi-Klug, Rose, Levitsky, Lynne, Shah, Rachana, Kelsey, Megan, Burke, Brian, Dabelea, Dana M., Divers, Jasmin, Marcovina, Santica, Stalbow, Lauren, Loos, Ruth J. F., Darst, Burcu F., Kooperberg, Charles, Raffield, Laura M., Haiman, Christopher, Sun, Quan, McCormick, Joseph B., Fisher-Hoch, Susan P., Ordoñez, Maria L., Meigs, James, Baier, Leslie J., González-Villalpando, Clicerio, González-Villalpando, Maria Elena, Orozco, Lorena, García-García, Lourdes, Moreno-Estrada, Andrés, Aguilar-Salinas, Carlos A., Tusié, Teresa, Dupuis, Josée, Ng, Maggie C. Y., Manning, Alisa, Highland, Heather M., Cnop, Miriam, Hanson, Robert, Below, Jennifer, Florez, Jose C., Leong, Aaron, Mercader, Josep M.
    Publicado 2023
    “…CONCLUSIONS/INTERPRETATION: Our results demonstrate the utility of TOPMed imputation for identifying low-frequency variants in understudied populations, leading to the discovery of novel disease associations and the improvement of polygenic scores. …”
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    The power of TOPMed imputation for the discovery of Latino-enriched rare variants associated with type 2 diabetes
  8. 489188
    “…Furthermore, lncRNA MEG3 could act as a sponge of miR-21-5p to upregulate PTEN and inactivate PI3K/AKT signaling, leading to the suppression of cell proliferation and invasion. …”
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    HNRNPA2B1-mediated m(6)A modification of lncRNA MEG3 facilitates tumorigenesis and metastasis of non-small cell lung cancer by regulating miR-21-5p/PTEN axis
  9. 489189
    “…BACKGROUND: Age-related macular degeneration (AMD), characterized by the degeneration of retinal pigment epithelium (RPE) and photoreceptors, is the leading cause of irreversible vision impairment among the elderly. …”
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    Inhibiting HIF-1 signaling alleviates HTRA1-induced RPE senescence in retinal degeneration
  10. 489190
    “…BACKGROUND: Complications from preterm birth (PTB) are the leading cause of death and disability in those under five years. …”
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    Development and internal validation of a non-invasive clinical tool to predict sufficient omega-3 levels in early pregnancy
  11. 489191
    “…Mechanistic analysis found that miR-150-5p from Sca-1(+) exosomes repressed the mitogen-activated protein kinase kinase kinase 3 (MEKK3)/JNK/c-Jun axis, leading to IL-6 and TNF-α downregulation, and subsequently reduced microglial polarization, all of which contributes to reduced ganglion cell apoptosis and preservation of proper retinal morphology. …”
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    Young Sca-1(+) bone marrow stem cell-derived exosomes preserve visual function via the miR-150-5p/MEKK3/JNK/c-Jun pathway to reduce M1 microglial polarization
  12. 489192
    “…However, during the last two decades, malaria incidence has declined due to concerted public health control efforts, including the widespread use of rapid diagnostic tests leading to increased recognition of non-malarial AFI etiologies. …”
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    Investigating the etiology of acute febrile illness: a prospective clinic-based study in Uganda
  13. 489193
    “…Moreover, acetate replenishment enhanced ac-H3K9 and ac-H4K12 in 5 × FAD mice, leading to an increase of NMDARs and AMPARs and a restoration of synaptic plasticity and cognitive function in an ACSS2-dependent manner. …”
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    ACSS2-dependent histone acetylation improves cognition in mouse model of Alzheimer’s disease
  14. 489194
    “…In this context, Brazil and Portugal defined a joint panel of four leading diabetes societies to update the guideline published in 2020. …”
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    2023 UPDATE: Luso-Brazilian evidence-based guideline for the management of antidiabetic therapy in type 2 diabetes
  15. 489195
    “…BACKGROUND: The overuse of antibiotics leads to the emergence of antibiotic-resistant microbes which causes high mortality worldwide. …”
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    Myco-synthesized copper oxide nanoparticles using harnessing metabolites of endophytic fungal strain Aspergillus terreus: an insight into antibacterial, anti-Candida, biocompatibility, anticancer, and antioxidant activities
  16. 489196
    “…The in vitro splice assay confirmed that this variant leads to ABCA4 transcripts without exon 17. ABCA4 Asp864_Gly863del was stable and retained 58% all-trans-retinal-activated ATPase activity compared to WT ABCA4. …”
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    Stargardt disease-associated in-frame ABCA4 exon 17 skipping results in significant ABCA4 function
  17. 489197
    “…Consequently, the probability of human exposure to diseases transmitted by ticks has increased, leading to a higher degree of risk associated with such diseases. …”
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    The current distribution of tick species in Inner Mongolia and inferring potential suitability areas for dominant tick species based on the MaxEnt model
  18. 489198
    “…BACKGROUND: Tuberculosis(TB) is among the leading causes of infectious death worldwide. Contact investigation is an evidence-based, World Health Organisation-endorsed intervention for timely TB diagnosis, treatment, and prevention but has not been widely and effectively implemented. …”
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    A user-centred implementation strategy for tuberculosis contact investigation in Uganda: protocol for a stepped-wedge, cluster-randomised trial
  19. 489199
    “…Tibial shaft fractures can be treated using casts, external fixators, plating, or intramedullary nails. Intramural nailing leads to faster union and reduced complications like malunion and shortening. …”
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    Functional outcomes of the knee and associated factors after intramedullary nailing of tibial diaphysial fractures at Addis Ababa Emergency, burn, and Trauma Hospital (AaEBT) hospital, Ethiopia
  20. 489200
    “…BACKGROUND: Worsening of heart failure (HF) symptoms is the leading cause of medical contact and hospitalization of patients with mildly reduced ejection fraction (HFmrEF). …”
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    Impact of signs and symptoms on the prognosis of patients with HFmrEF
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