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489721por Scully, Tiffany, James, Annie, Kang, Chifei, Antoniou, Irini M, Ettela, Abora, Wong, Nicholas J, Azeloglu, Evren U, Kase, Nathan G, Qiu, Yunping, Kurland, Irwin J, Gallagher, Emily Jane“…Overall, these findings suggest that HTG, independently of other obesity-associated characteristics such as hyperinsulinemia and hyperglycemia, leads to changes in intracellular lipid metabolism and promotes TNBC progression. …”
Publicado 2020
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489722SAT-622 Heterogeneity of Familial Partial Lipodystrophy Type 2 from a Genotype-Phenotype Perspectivepor de Freitas, Maria Cristina Foss, Eldin, Abdelwahab Jalal, Akinci, Baris, Corsa, Callie, MacDougald, Ormond A, Oral, Elif A“…Our data suggest more fat preservation in LMNA R482Q carriers, presumably leading to a later diagnosis of lipodystrophy and metabolic abnormalities. …”
Publicado 2020
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489723“…He admitted to severe fatigue and muscle cramps for over one year leading to a car accident. He was sent to the emergency room and diagnosed with hypocalcemia requiring IV calcium gluconate. …”
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489724por Carpenter, Thomas O, Miller, Paul D, Weber, Thomas J, Peacock, Munro, Insogna, Karl L, Kumar, Rajiv, Luca, Diana, Cimms, Tricia, Roberts, Mary Scott, de Beur, Suzanne Jan“…Tumor-induced Osteomalacia (TIO) is a rare condition in which excess FGF23 produced by a tumor leads to renal phosphate wasting, impaired 1,25(OH)(2)D synthesis, osteomalacia, fractures, weakness, fatigue, and decreased mobility. …”
Publicado 2020
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489725por Roelfsema, Ferdinand, Liu, Peter Y, Yang, Rebecca, Takahashi, Paul, Veldhuis, Johannes D“…The ApEn increase points to decreased secretory regularity imposed by enhanced CRF signaling, rather than diminished cortisol feedback, which leads to greater secretory regularity. Conclusion. …”
Publicado 2020
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489726por MAIONE, Luigi, SALENAVE, Sylvie, TRABADO, Severine, Chanson, Philippe, Kaiser, Ursula B, Young, Jacques“…Hypogonadotropic hypogonadism (HH) is a clinical condition defined by subnormal serum testosterone levels with low serum gonadotropins, which leads to infertility and reduced testicular function in men. …”
Publicado 2020
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489727por Rizk, Nasser M, Saleh, Amina, ElGamal, Abdelrahman, Elsayegh, Dina, Cakir, Isin, Ghamari-Langroudi, Masoud“…Decreased glucose transport to the peripheral tissues, mainly skeletal muscle, leads to reduced total glucose disposal and hyperglycemia. …”
Publicado 2020
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489728“…Both are administered intermittently, act on PTH1R receptors on osteoblasts and osteocytes leading to an increase in bone mineral density and bone strength. …”
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489729por Carrasco-Hernandez, Laura, Jódar-Sánchez, Francisco, Núñez-Benjumea, Francisco, Moreno Conde, Jesús, Mesa González, Marco, Civit-Balcells, Antón, Hors-Fraile, Santiago, Parra-Calderón, Carlos Luis, Bamidis, Panagiotis D, Ortega-Ruiz, Francisco“…BACKGROUND: Smoking cessation is a persistent leading public health challenge. Mobile health (mHealth) solutions are emerging to improve smoking cessation treatments. …”
Publicado 2020
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489730por Lopreiato, Vincenzo, Palma, Ernesto, Minuti, Andrea, Loor, Juan J., Lopreiato, Mariangela, Trimboli, Francesca, Morittu, Valeria Maria, Spina, Anna Antonella, Britti, Domenico, Trevisi, Erminio“…SIMPLE SUMMARY: The innate and adaptive immune system of dairy cows is impaired during the transition period, leading to an increase in susceptibility to infectious disease. …”
Publicado 2020
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489731por Meller, Tina, Schmitt, Simon, Stein, Frederike, Brosch, Katharina, Grotegerd, Dominik, Dohm, Katharina, Meinert, Susanne, Andlauer, Till F M, Rietschel, Marcella, Müller-Myhsok, Bertram, Nöthen, Markus M, Dannlowski, Udo, Krug, Axel, Kircher, Tilo, Nenadić, Igor“…DISCUSSION: Our finding is the first to integrate polygenic and poly-environmental markers with MRI parameters to demonstrate that the interaction of these cumulated risk factors leads to the emergence of subclinical symptoms through changes in brain structure. …”
Publicado 2020
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489732por Béchard, Laurent, Corbeil, Olivier, Plante, Maude, Thivierge, Marc-André, Lafrenière, Charles-Émile, Roy, Marc-André, Demers, Marie-France, Corbeil, Olivier“…Despite this, a mean number of 4 red events (ranging from 1 to 10 events) were subsequently observed in those patients, leading to clozapine cessation in 4/8 patients. One other patient responded to G-CSF but the clinical team felt uncomfortable to maintain clozapine in such circumstances. …”
Publicado 2020
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489733por Yoshida, Kazunari, Maciukiewicz, Malgorzata, Marshe, Victoria, Tiwari, Arun, Brandl, Eva, Lieberman, Jeffrey, Meltzer, Herbert, Kennedy, James, Mueller, Daniel“…BACKGROUND: Antipsychotic-induced weight gain (AIWG) is a common and serious side effect with antipsychotic medications, which frequently leads to obesity and metabolic disorders. Previous single-gene analyses have shown an overlap between AIWG and genes associated with obesity and energy homeostasis (e.g., MC4R). …”
Publicado 2020
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489734“…All hub team services were delivered remotely through VIDYO, a leading, HIPPA compliant TH platform which was used on hand-held devices for care deliver in the subjects’ homes, as well as in local CMHCs. …”
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489735por Sosso, Samuel Martin, Tchouaket, Michel Carlos Tommo, Fokam, Joseph, Simo, Rachel Kamgaing, Torimiro, Judith, Tiga, Aline, Lobe, Elise Elong, Ambada, Georgia, Nange, Achille, Semengue, Ezechiel Ngoufack Jagni, Nka, Alex Durand, Tala, Valère, Chenwi, Collins, Abba, Aissatou, Ka’e, Aude Christelle, Yagai, Bouba, Colizzi, Vittorio, Ndjolo, Alexis“…BACKGROUND: Human papillomavirus (HPV) is the leading cause of cervical cancers, causing 270.000 deaths annually worldwide of which 85% occur in developing countries with an increasing risk associated to HIV infection. …”
Publicado 2020
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489736por Torz, Lola J., Osborne-Lawrence, Sherri, Rodriguez, Juan, He, Zhenyan, Cornejo, María Paula, Mustafá, Emilio Román, Jin, Chunyu, Petersen, Natalia, Hedegaard, Morten A., Nybo, Maja, Damonte, Valentina Martínez, Metzger, Nathan P., Mani, Bharath K., Williams, Kevin W., Raingo, Jesica, Perello, Mario, Holst, Birgitte, Zigman, Jeffrey M.“…The GHSR-A203E mutation also blunts GH release, and in aged mice leads to reduced body length and femur length, which are consistent with the short stature of human carriers of the GHSR-A204E mutation.…”
Publicado 2020
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489737por Hui, Kenrie P Y, Cheung, Man-Chun, Perera, Ranawaka A P M, Ng, Ka-Chun, Bui, Christine H T, Ho, John C W, Ng, Mandy M T, Kuok, Denise I T, Shih, Kendrick C, Tsao, Sai-Wah, Poon, Leo L M, Peiris, Malik, Nicholls, John M, Chan, Michael C W“…BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in December 2019, causing a respiratory disease (coronavirus disease 2019, COVID-19) of varying severity in Wuhan, China, and subsequently leading to a pandemic. The transmissibility and pathogenesis of SARS-CoV-2 remain poorly understood. …”
Publicado 2020
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489738por Jin, Jiamin, Ma, Yerong, Tong, Xiaomei, Yang, Weijie, Dai, Yongdong, Pan, Yibin, Ren, Peipei, Liu, Liu, Fan, Heng-Yu, Zhang, Yinli, Zhang, Songying“…Excessive testosterone induces ER stress and UPR activation in human cumulus cells, leading to cell apoptosis. Metformin has potential inhibitory effects on ER stress and UPR activation, as demonstrated in human pancreatic beta cells and obese mice. …”
Publicado 2020
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489739por Dunbar, Richard L., Gaudet, Daniel, Davidson, Michael, Rensfeldt, Martin, Yang, Hong, Nilsson, Catarina, Kvarnström, Mats, Oscarsson, Jan“…However, increases in pre-dose fasting plasma EPA + DHA over the preceding 4-week dosing period were similar between treatments, leading overall to non-significant differences in baseline (day 0)-adjusted AUC(0–24) and C(max) EPA + DHA values. …”
Publicado 2020
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489740por Fernando-Macías, Ester, Fernández-García, Maria Teresa, García-Pérez, Eva, Porrero Guerrero, Belén, López-Arévalo, Camilo, Rodríguez-Uría, Raquel, Sanz-Navarro, Sandra, Vázquez-Villa, José Fernando, Muñíz-Salgueiro, María Carmen, Suárez-Fernández, Laura, Galván, José A., Barneo-Caragol, Clara, García-Ocaña, Marcos, de los Toyos, Juan R., Barneo-Serra, Luis“…BACKGROUND: Colorectal cancer is the second leading cause of cancer death. Almost half of the patients present recurrence within 5 years after the treatment of the primary tumor, the majority, with metastasis. …”
Publicado 2020
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