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  1. 489841
    “…BACKGROUND: Hypertensive Disorder of Pregnancy (HDP) is one of the leading causes of maternal mortality and morbidity amongst pregnant women in the world. …”
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    Factors associated with blood pressure check-up during pregnancy among women of reproductive age in Tanzania: an analysis of data from 2015—16 Tanzania Demographic and Health Survey and Malaria Indicators Survey
  2. 489842
    “…IMPORTANCE: Obesity is a growing public health threat leading to serious health consequences. Late bedtime and sleep loss are common in modern society, but their associations with specific obesity types are not well characterized. …”
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    Timing and Length of Nocturnal Sleep and Daytime Napping and Associations With Obesity Types in High-, Middle-, and Low-Income Countries
  3. 489843
    “…BACKGROUND: Transfemoral amputation is a serious intervention that alters the locomotion pattern, leading to secondary disorders and reduced quality of life. …”
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    Robot-mediated overground gait training for transfemoral amputees with a powered bilateral hip orthosis: a pilot study
  4. 489844
    “…IMPORTANCE: Alzheimer disease (AD) is the leading cause of death in individuals with Down syndrome (DS). …”
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    Association of Apolipoprotein E ɛ4 Allele With Clinical and Multimodal Biomarker Changes of Alzheimer Disease in Adults With Down Syndrome
  5. 489845
    “…This is believed to be driven by disease-inherent systemic pathophysiologies, which are also assumed to drive muscle cells into a state of anabolic resistance, leading to impaired abilities to adapt to resistance exercise training. …”
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    Chronic obstructive pulmonary disease does not impair responses to resistance training
  6. 489846
    “…We also observed cross-regulation of decay versus storage mRNP granules; knockdown of Fmrp enhances accumulation of Dcp1a puncta, whereas knockdown of Dcp1a leads to increased Fmrp in puncta. CONCLUSIONS: Taken together, our results provide evidence that the balance of mRNA turnover versus utilization is specific for distinct cellular states. …”
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    mRNP granule proteins Fmrp and Dcp1a differentially regulate mRNP complexes to contribute to control of muscle stem cell quiescence and activation
  7. 489847
    “…BACKGROUND: Diabetic nephropathy (DN) is currently the leading cause of end-stage renal disease globally. …”
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    ets1 associates with KMT5A to participate in high glucose-mediated EndMT via upregulation of PFN2 expression in diabetic nephropathy
  8. 489848
    por Shan, Liping, Liu, Wei, Zhan, Yunhong
    Publicado 2021
    “…CONCLUSION: The present study sheds light on the fact that lncRNA HAND2-AS1 exerted as a tumor suppressor by releasing RARB from miR-146, leading to tumor proliferation and invasion inhibition. …”
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    LncRNA HAND2-AS1 exerts anti-oncogenic effects on bladder cancer via restoration of RARB as a sponge of microRNA-146
  9. 489849
    “…SIMPLE SUMMARY: The average human life expectancy is increasing worldwide, which is leading to increases in the proportion of elderly patients (≥80 years) with gastric cancer. …”
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    Impact of Comorbidities, Sarcopenia, and Nutritional Status on the Long-Term Outcomes after Endoscopic Submucosal Dissection for Early Gastric Cancer in Elderly Patients Aged ≥ 80 Years
  10. 489850
    Publicado 2021
    “…BACKGROUND: Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. …”
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    Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study
  11. 489851
    “…As 12-month weight loss was completely mediated by 4-month weight loss, intervention targets should focus on promoting early and frequent dietary intake self-monitoring and self-weighing to promote early weight loss, which leads to long-term success. TRIAL REGISTRATION: ClinicalTrials.gov NCT02063178; https://clinicaltrials.gov/ct2/show/NCT02063178…”
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    Assessing the Contribution of Self-Monitoring Through a Commercial Weight Loss App: Mediation and Predictive Modeling Study
  12. 489852
    “…Take-Home Message: Nosocomial infection is a leading cause of mortality in critically ill patients in the ICU. …”
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    Synbiotic Therapy Prevents Nosocomial Infection in Critically Ill Adult Patients: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials Based on a Bayesian Framework
  13. 489853
    “…BACKGROUND: Degenerative osteoarthritis (OA) often leads to pain and stiffness of the affected joints, which may affect the physical performance and decrease the quality of life of people with degenerative knee OA. …”
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    Impacts of tai chi exercise on functional fitness in community-dwelling older adults with mild degenerative knee osteoarthritis: a randomized controlled clinical trial
  14. 489854
    “…Failed conservative management often leads arthroscopy and drilling of the lesion. Two different primary drilling techniques have been utilized, but no prospective studies have compared their relative effectiveness. …”
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    Trans-articular versus Retro-articular Drilling of Stable Osteochondritis Dissecans of the Knee: A Prospective Randomized Controlled Trial by the ROCK Multicenter Study Group
  15. 489855
    “…When IC is not available, predicted resting energy expenditure (pREE) equations are commonly utilized, which often inaccurately predict metabolic demands leading to over- or under-feeding. This study aims to longitudinally assess mREE via IC in critically ill patients with SARS-CoV-2 (COVID-19) infection throughout the entirety of, often prolonged, intensive care unit (ICU) stays and compare mREE to commonly utilized pREE equations. …”
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    Prolonged progressive hypermetabolism during COVID-19 hospitalization undetected by common predictive energy equations
  16. 489856
    “…The observed inconsistent pattern indicates that there were no association of school openings and COVID-19 morbidity and mortality trends in Croatia and that other factors were leading to increasing and decreasing numbers. This emphasizes the need to consider the introduction of other effective and less harmful measures by stakeholders, or at least to use school closures as a last resort.…”
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    COVID-19 incidence, hospitalizations and mortality trends in Croatia and school closures
  17. 489857
    “…A reduction in MPR can be caused by preceding SARS-CoV-2-associated direct as well as secondary triggered mechanisms leading to diffuse CMD, and may explain ongoing symptoms of exercise dyspnoea and PVFS in some patients after COVID-19 infection.…”
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    A cardiovascular magnetic resonance imaging-based pilot study to assess coronary microvascular disease in COVID-19 patients
  18. 489858
    “…Reduced interaction with peers because of the lockdown and social distancing, leading to fewer infections that may trigger SCA-complications, may explain the reduced incidence of SCA complications in this population during the COVID-19 lockdown period in Uganda. …”
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    Impact of a National Lockdown for COVID-19 on Morbidity and Mortality Among Children with Sickle Cell Anaemia at a Tertiary Care Hospital in Uganda
  19. 489859
    “…Introduction Coronavirus disease (COVID-19) may induce a hypercoagulable state, leading to microvascular and macrovascular thromboses, as shown in observational and autopsy studies (Giannis, Ziogas, and Gianni 2020; Carsana et al. 2020; Lax et al. 2020). …”
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    Anticoagulation Management and Outcomes in Covid-19 Patients:a Multi-Center Retrospective Cohort Study
  20. 489860
    “…PROBLEM: According to Joint United Nations Programme on HIV/AIDS (UNAIDS) and the World Health Organization, HIV is the leading cause of youth mortality in Africa, and the second cause of death among young people worldwide. …”
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    Financial education for HIV‐vulnerable youth, orphans, and vulnerable children: A systematic review of outcome evidence
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