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  1. 489861
    “…BACKGROUND: Anemia, the most common micro-nutrient deficiency disorder, is the world’s second leading cause of morbidity and morbidity, affecting 24.8% of the population, of which 47.4% are under-five children. …”
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    Magnitude of anemia and associated factors among children aged 6–59 months at Debre Markos referral hospital, Northwest Ethiopia: a hospital-based cross-sectional study
  2. 489862
    “…The treatment of T2DM can be challenging because of different comprehensive therapeutic targets and individual variability of the patients, leading to the need for precise, personalized treatment. …”
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    Effective Treatment Recommendations for Type 2 Diabetes Management Using Reinforcement Learning: Treatment Recommendation Model Development and Validation
  3. 489863
    “…IMPORTANCE: Cardiovascular disease remains the second leading cause of death in Canada. Monitoring and tracking the trends and disparities in major cardiovascular risk factors could provide benchmarks for future cardiovascular health strategies. …”
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    Trends and Regional Variation in Prevalence of Cardiovascular Risk Factors and Association With Socioeconomic Status in Canada, 2005-2016
  4. 489864
    “…No serious TEAEs, deaths, or drug-related TEAEs leading to withdrawal were reported. CONCLUSION: Celecoxib oral solution is a safe, effective COX-2-selective nonsteroidal anti-inflammatory drug for the treatment of acute migraine. …”
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    A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy, Tolerability, and Safety of Celecoxib Oral Solution (ELYXYB) in Acute Treatment of Episodic Migraine with or without Aura
  5. 489865
    “…Conclusion: Longitudinal monitoring of IBD patients and integrating data related to the contributing/risk factors including psychological state, physiological conditions, inflammatory/immune modulations, and microbiome composition/function, could help to explain how major factors associate and interrelate leading to exacerbation of symptoms and disease activity. …”
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    A Review of Inflammatory Bowel Disease: A Model of Microbial, Immune and Neuropsychological Integration
  6. 489866
    “…BACKGROUND: The leading cause of mortality for patients with the neurofibromatosis type 1 (NF1) cancer predisposition syndrome is the development of malignant peripheral nerve sheath tumor (MPNST), an aggressive soft tissue sarcoma. …”
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    Cell-free DNA ultra-low-pass whole genome sequencing to distinguish malignant peripheral nerve sheath tumor (MPNST) from its benign precursor lesion: A cross-sectional study
  7. 489867
    “…Numerous studies have shown that inter-professional communication gaps are the leading cause of adverse medical events that compromise the quality of patient care in the clinical setting. …”
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    Nurse–Physician Communication in Patient Care and Associated Factors in Public Hospitals of Harari Regional State and Dire-Dawa City Administration, Eastern Ethiopia: A Multicenter-Mixed Methods Study
  8. 489868
    “…A likely reason is that the prevalence of pathophysiologic processes leading up to the “same” clinical syndrome can be distributed differently in different and smaller-sized cohorts. …”
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    Proteomic signatures predict preeclampsia in individual cohorts but not across cohorts – implications for clinical biomarker studies
  9. 489869
    “…This study is a pilot validation and the genesis of a project that aims ultimately to drive early intervention leading to reduced morbidity and mortality rates in this illness group. …”
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    Identification of high risk and early stage eating disorders: first validation of a digital screening tool
  10. 489870
    “…BACKGROUND: Liver fibrosis leads to liver-related events in patients with chronic hepatitis C (CHC) infection. …”
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    Non-invasive tests for predicting liver outcomes in chronic hepatitis C patients: A systematic review and meta-analysis
  11. 489871
    “…Important limitations of the study were the relatively short follow-up time, the limited number of events for some outcomes, and that the outcome obesity is often not considered as a disease and therefore not caught by registers, likely leading to an underestimation of obesity in both children born after ART and children born after SC. …”
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    Cardiovascular disease, obesity, and type 2 diabetes in children born after assisted reproductive technology: A population-based cohort study
  12. 489872
    “…Pulmonary embolism (PE) is a leading cause of mortality in postoperative patients. …”
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    Development and validation of a novel risk assessment model to estimate the probability of pulmonary embolism in postoperative patients
  13. 489873
    “…RESULTS: We found that mild central nervous system (CNS) sulfatide losses within myelinating cells are sufficient to activate disease-associated microglia and astrocytes, and to increase the expression of AD risk genes (e.g., Apoe, Trem2, Cd33, and Mmp12), as well as previously established causal regulators of the immune/microglia network in late-onset AD (e.g., Tyrobp, Dock, and Fcerg1), leading to chronic AD-like neuroinflammation and mild cognitive impairment. …”
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    Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer’s disease-like neuroinflammation and cognitive impairment
  14. 489874
    “…PURPOSE: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) is an important event in the course of chronic obstructive pulmonary disease that negatively affects patients’ quality of life and leads to higher socioeconomic costs. While previous studies have demonstrated a significant association between urban air pollution and hospitalization for AECOPD, there is a lack of research on the impact of particulate matter (PM) on inflammation and coagulation in AECOPD inpatients. …”
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    Effect of urban air pollution on CRP and coagulation: a study on inpatients with acute exacerbation of chronic obstructive pulmonary disease
  15. 489875
    “…During the first 2 months of lockdown, PwD missed on average 20.5 h of formal care in a month (P < 0.001) leading to an approximately 100% increase in informal care, which was particularly pronounced in personal hygiene (6.9 vs. 11.4 days in a month, P < 0.001) and supervision (9.2 vs. 17.6 days in a month; P < 0.001). …”
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    The consequences of COVID-19 lockdown for formal and informal resource utilization among home-dwelling people with dementia: results from the prospective PAN.DEM study
  16. 489876
    “…Suspected malignant incidental findings were reported in 46 patients (46/225, 20.4%), leading to further examinations and final detection of nine synchronous cancers (9/225, 4.0%). …”
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    Benefits and harms of implementing [(18)F]FDG-PET/CT for diagnosing recurrent breast cancer: a prospective clinical study
  17. 489877
    “…BACKGROUND: Over a million adolescents die globally each year from preventable or treatable causes, with injuries (intentional and unintentional) being the leading cause of these deaths. To inform strategies to prevent these injuries, we aimed to assess psychosocial factors associated with serious injury occurrence, type, and mechanism in adolescents. …”
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    The relationship between psychosocial circumstances and injuries in adolescents: An analysis of 87,269 individuals from 26 countries using the Global School-based Student Health Survey
  18. 489878
    “…The hexalacunary anion [H(2)P(V)(2)W(VI)(12)O(48)](12−) undergoes time-dependent hydrolysis resulting in a mixture of [H(2)P(V)(2)W(VI)(12)O(48)](12−), [P(V)(8)W(VI)(48)O(184)](40−), [P(V)(2)W(VI)(19)O(69)(H(2)O)](14−) and [α(2)-P(V)(2)W(VI)(17)O(61)](10−) which together leads to comparable inhibitory activity (K(i) = 7.5 mM) after 48 h. …”
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    Wells–Dawson phosphotungstates as mushroom tyrosinase inhibitors: a speciation study
  19. 489879
    “…IMPORTANCE: Dyslipidemia, the prevalence of which historically has been low in China, is emerging as the second leading yet often unaddressed factor associated with the risk of cardiovascular diseases. …”
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    Prevalence of Dyslipidemia and Availability of Lipid-Lowering Medications Among Primary Health Care Settings in China
  20. 489880
    “…IMPORTANCE: Chronic back pain (CBP) is a leading cause of disability, and treatment is often ineffective. …”
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    Effect of Pain Reprocessing Therapy vs Placebo and Usual Care for Patients With Chronic Back Pain: A Randomized Clinical Trial
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