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  1. 489941
    “…Bmi‐1 deficiency stimulated NF‐κB‐p65‐dependent SASP, leading to cardiac dysfunction, cardiomyocyte hypertrophy and senescence. …”
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    Bmi‐1‐RING1B prevents GATA4‐dependent senescence‐associated pathological cardiac hypertrophy by promoting autophagic degradation of GATA4
  2. 489942
    “…Spinal muscular atrophy leads to progressive muscle denervation, skeletal muscle atrophy and loss of motor function and ambulation, though phenotypes vary along a disease continuum. …”
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    Systematic Literature Review to Assess the Cost and Resource Use Associated with Spinal Muscular Atrophy Management
  3. 489943
    “…BACKGROUND: Childhood diarrhea remains a major disease burden, particularly in developing countries, and is a leading cause of death in children aged < 5 years, worldwide. …”
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    Efficacy and safety of Bacillus clausii (O/C, N/R, SIN, T) probiotic combined with oral rehydration therapy (ORT) and zinc in acute diarrhea in children: a randomized, double-blind, placebo-controlled study in India
  4. 489944
    “…Chronic lateral deviation of the hallux leads to proximal interphalangeal joint flexion contracture, metatarsophalangeal joint subluxation and ultimately a cross-toe deformity. …”
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    The Influence of Concomitant Hammertoe Correction on Postoperative Outcomes in Patients Undergoing Hallux Valgus Correction
  5. 489945
    “…CONCLUSION: Postinfection maternal humoral immunity wanes during pregnancy, leading to low or undetectable protective titers for a marked proportion of patients. …”
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    Boosting maternal and neonatal humoral immunity following SARS-CoV-2 infection using a single messenger RNA vaccine dose
  6. 489946
    “…Perlecan localizes acetylcholinesterase in the neuromuscular junction and is of functional significance in neuromuscular control. Perlecan mutation leads to Schwartz-Jampel Syndrome, functional impairment of the biomechanical properties of the intervertebral disc, variable levels of chondroplasia and myotonia. …”
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    Perlecan, A Multi-Functional, Cell-Instructive, Matrix-Stabilizing Proteoglycan With Roles in Tissue Development Has Relevance to Connective Tissue Repair and Regeneration
  7. 489947
    “…BACKGROUND: Bloodstream infections have been the leading complications in cancer patients because they are at high risk for antibiotic-resistant bacterial infections. …”
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    Bacterial profile and antimicrobial susceptibility patterns in cancer patients
  8. 489948
    “…Besides, β-amyloid pathology may play an initiating role in Alzheimer's disease onset, leading to subsequent tau increases. However, it is still unclear whether individuals with different β-amyloid pathways have distinct spatial patterns of cortical tau tangles in early amyloidosis stage. …”
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    β-Amyloid discordance of cerebrospinal fluid and positron emission tomography imaging shows distinct spatial tau patterns
  9. 489949
    “…However, it has been noted that many of these studies have likely suffered from dataset bias, leading to overly optimistic results. The purpose of this study was to thoroughly investigate to what extent biases have influenced the performance of a range of previously proposed and promising convolutional neural networks (CNNs), and to determine what performance can be expected with current CNNs on a realistic and unbiased dataset. …”
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    Automatic coronavirus disease 2019 diagnosis based on chest radiography and deep learning – Success story or dataset bias?
  10. 489950
    “…CONCLUSION: An [(18)F]FDG-PET/CT-driven diagnostic workup of indeterminate thyroid nodules leads to practice changing management, accurately and oncologically safely reducing futile surgeries by 40%. …”
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    [(18)F]FDG-PET/CT to prevent futile surgery in indeterminate thyroid nodules: a blinded, randomised controlled multicentre trial
  11. 489951
    por Teame, Kiros, Debie, Ayal, Tullu, Mikiyas
    Publicado 2022
    “…Therefore, strengthening emotional intelligence and empowering managers will be very helpful to improve leading health cares. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12913-022-07879-6.…”
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    Healthcare leadership effectiveness among managers in Public Health institutions of Addis Ababa, Central Ethiopia: a mixed methods study
  12. 489952
    “…With decreased transcellular and extracellular transport of ACE2 being possible in subjects with the gene mutation, it can be postulated more ACE2 will be found intracellularly leading to increased cellular entry of SARS CoV-2 and possibility of orchitis sequelae. …”
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    Whole Exome Sequencing Identifies a Rare Mutation in NACAD as a Possible Cause of COVID orchitis in Brothers
  13. 489953
    “…Despite advances in prevention, diagnosis, and therapy, the absolute number of cases is increasing every year due to aging and the growth of high-risk populations, and gastric cancer is still a leading cause of cancer-related death. Gastric cancer is a consequence of the complex interaction of microbial agents, with environmental and host factors, resulting in the dysregulation of multiple oncogenic and tumor-suppressing signaling pathways. …”
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    Berberine retarded the growth of gastric cancer xenograft tumors by targeting hepatocyte nuclear factor 4α
  14. 489954
    “…INTRODUCTION: Diabetic nephropathy is the leading cause of kidney failure. Clinical practice guidelines recommend prescribing renin–angiotensin aldosterone system inhibitors (RAASi) to prevent diabetic nephropathy at any stage. …”
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    The effect of renin–angiotensin–aldosterone system inhibitors on continuous and binary kidney outcomes in subgroups of patients with diabetes: a meta-analysis of randomized clinical trials
  15. 489955
    “…BACKGROUND: Chronic kidney disease (CKD) is the 12(th) leading cause of death worldwide. Cost-of-illness studies of CKD are scarce in developing countries. …”
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    Cost of illness of chronic kidney disease in Lebanon: from the societal and third-party payer perspectives
  16. 489956
    “…The X-ray absorption fine structure spectra reveal that abundant Mn‐S bonds connect the heterostructure interfaces of Ni(x)S(y)@MnO(x)H(y), leading to a strong electronic interaction, which improves the intrinsic activities of hydrogen evolution reaction and oxygen evolution reaction (OER). …”
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    Interface Engineering of Ni(x)S(y)@MnO(x)H(y) Nanorods to Efficiently Enhance Overall-Water-Splitting Activity and Stability
  17. 489957
    “…A more sedentary lifestyle is linked to increased body fat leading to increments in leptin levels. Since rodent and human studies in high-income countries have shown that starvation-induced hypoleptinemia triggers high PA, efforts are warranted to pursue the hypothesis that low leptin levels in lean children of low- and middle-income countries (LMIC) are also associated with high PA. …”
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    Low leptin levels are associated with elevated physical activity among lean school children in rural Tanzania
  18. 489958
    “…INTRODUCTION: Cerebral vasospasm (VSP) is the leading risk factor of neurological deterioration (i.e., delayed cerebral ischemia [DCI] and cerebral infarction) after aneurysmal subarachnoid hemorrhage (aSAH) and a cause of morbidity and mortality. …”
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    Economic and Humanistic Burden of Cerebral Vasospasm and Its Related Complications after Aneurysmal Subarachnoid Hemorrhage: A Systematic Literature Review
  19. 489959
    “…Maize (Zea mays L.) is the leading cereal crop and staple food in many parts of the world. …”
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    Development of β-carotene, lysine, and tryptophan-rich maize (Zea mays) inbreds through marker-assisted gene pyramiding
  20. 489960
    “…The impregnation of metals leads to a decrease in the surface area and pore volume as follows NiMoP-S/γ-Al(2)O(3)-MgO < MoP-S/γ-Al(2)O(3)-MgO < NiP-S/γ-Al(2)O(3)-MgO < Al(2)O(3)-MgO < Al(2)O(3) (unimodal pore size distribution), propitiating a pseudo bimodal pore size distribution with Dp-BJH between ∼5–7 nm and 11.8–14.2 nm for the presence of MgO. …”
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    Al(2)O(3)-MgO Supported Ni, Mo, and NiMo Mixed Phosphidic-Sulphidic Phase for Hydrotreating of Stearic and Oleic Acids Into Green Diesel
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