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  1. 490041
    “…Absorption of ultraviolet B (UVB) radiation by the B ring of 7-dehydrocholesterol (7-DHC) leads to the transformation of 7-DHC to previtamin D(3), which after absorption of additional UVB isomerizes to tachysterol(3) (T(3)) and lumisterol3 (L(3)). …”
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    RF15 | PMON293 Metabolic activation of tachysterol to biologically active hydroxyderivatives that act on VDR, AhR, LXRs and PPARγ receptors
  2. 490042
    “…HYPOTHESIS: Activation of glucocorticoid receptor (NR3C1, GR) results in the inhibition of Hh transcription factor GLI1 leading to reduced SSTR expression. METHODS: We developed a human pituitary adenoma organoid model (hPITOiPSC) from induced pluripotent stem cells treated with the glucocorticoid receptor (GR) antagonist mifepristone, and co-treated them with or without SSTR agonists pasireotide or octreotide. …”
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    RF01 | PMON168 Hedgehog-Induced Somatostatin Receptor Expression is Inhibited by the Activation of the Glucocorticoid Receptor Signaling Pathway in Human Pituitary Adenoma Organoids
  3. 490043
    “…The prevalence of obesity has increased worldwide leading to an increase in associated comorbidities and mortality. …”
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    RF24 | PSUN108 Inpatient and Readmission Outcomes Following Endoscopic Gastrectomy Versus Gastrojejunostomy in Patients with Morbid Obesity: A Nationwide Retrospective Analysis
  4. 490044
    “…Visceral adipose tissue (VAT) is a metabolically unfavorable ectopic fat depot, which is highly inflamed and dysfunctional. Fat redistribution leading to VAT accumulation is related to increased CVD risk. …”
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    RF12 | PSUN104 Visceral adiposity index as a measure of cardiometabolic disease in persons living with HIV
  5. 490045
    “…WHAT IS KNOWN ALREADY: Embryo culture in G3 or K-SICM medium leads to differences in embryonic, neonatal and childhood outcomes, including growth and weight. …”
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    At age 9, the methylome of assisted reproductive technology children that underwent embryo culture in different media is not significantly different on a genome-wide scale
  6. 490046
    “…They can rarely co-exist in the same patient (1) leading to an unpredictable clinical course and pose a therapeutic challenge, necessitating close monitoring. …”
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    PSAT346 Persistent Fluctuation Between Hypothyroidism and Hyperthyroidism in a Patient with Both Hashimoto's Thyroiditis and Graves’ Disease: Challenges in Diagnosis and Treatment Approach
  7. 490047
    por Myers, Kyle, Dahir, Kathryn
    Publicado 2022
    “…CONCLUSION: This case demonstrates how the rare entity of hereditary multiple osteochondromas can have variable clinical presentations leading to its misdiagnosis and highlights the need for ongoing research into non-surgical treatment options. …”
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    RF30 | PSAT134 Autosomal Dominant Hereditary Multiple Osteochondromas Misdiagnosed As Paget's Disease of Bone
  8. 490048
    “…BACKGROUND: Breast cancer (BC) is the most diagnosed cancer and the second-leading cause of cancer-associated death in women in the United States. …”
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    OR30-5 Androgen-Regulated Secreted Factors Promote Tumorigenesis and Immune Suppression in Breast Cancer
  9. 490049
    “…Human anti-mouse antibodies (HAMA) treated TSH was within normal limits (1.4; ref: 0.4-4.5 mIU/L; Siemens). Leading differential diagnosis was initially thyroid hormone resistance; however subsequent labs, done by PCP for non-specific symptoms, revealed a suppressed parathyroid hormone (PTH) (<6; ref 15-65 pg/mL) with normal serum calcium levels. …”
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    RF23 | PSAT300 The Curious Case of Abnormal Thyroid Function Tests: Think Streptavidin Interference
  10. 490050
    “…She presented with a blood glucose (BG) of 659 mg/dL, anion gap of 21, serum bicarbonate 17 mmol/L, beta-hydroxybutyrate 3.82 mmol/L (normal < 0.27 mmol/L), serum osmolarity 319 mOsm/kg, serum creatinine 2.83 mg/dL (baseline 1.38 mg/dL), C-peptide 4.3 ng/mL (normal 1.1–4.4 ng/mL), negative GAD-65 antibodies and Islet Antigen 2 antibodies, septic workup were non-revealing, leading to the diagnosis of alpelisib-associated DKA. …”
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    RF07 | PSUN359 Alpelisib-induced Diabetic Ketoacidosis
  11. 490051
    “…Our results suggest that these variants could alter the interaction of the Spike and the human ACE2 protein, losing or creating new inter-protein contacts, enhancing viral fitness by improving binding affinity, and leading to an increase in infectivity, virulence, and transmission. …”
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    Computational modeling of the effect of five mutations on the structure of the ACE2 receptor and their correlation with infectivity and virulence of some emerged variants of SARS-CoV-2 suggests mechanisms of binding affinity dysregulation
  12. 490052
    “…BACKGROUND: Mental health has become a global problem, among which anxiety and depression disorder were ranked as the first and sixth leading causes of disability, respectively, according to the World Health Organization (WHO). …”
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    Anxiety and depression and their interdependent influencing factors among medical students in Inner Mongolia: the cross-sectional survey
  13. 490053
    “…When graded with WBCT, the subchondral cyst in the proximal phalanx and metatarsal head were better delineated leading to higher grade in WBCT which infer WBCT grading system for HR can aid in early detection of advanced HR with high radiographic grades and potentially guide treatment accordingly.…”
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    Comparison Between Hallux Rigidus Parameters Assessed by Conventional Radiographs and Weight- Bearing CT
  14. 490054
    “…The corresponding socio-economic burden of stroke, which is the leading cause of disability, is enormous. Global costs of stroke are estimated at 721 billion US dollars, which is 0.66% of the global GDP. …”
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    Ischemic stroke of unclear aetiology: a case-by-case analysis and call for a multi-professional predictive, preventive and personalised approach
  15. 490055
    “…Multiorgan failure was the leading cause of death (192 [36%] of 528 patients who died with available data). …”
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    In-hospital and 6-month outcomes in patients with COVID-19 supported with extracorporeal membrane oxygenation (EuroECMO-COVID): a multicentre, prospective observational study
  16. 490056
    “…This finding commonly leads surgeons to perform a lateral column lengthening osteotomy for abduction correction, a complex surgery with potential complications. …”
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    Talar Head Coverage Correction in the Absence of Lateral Column Lengthening: A Prospective Study with Calcaneal Osteotomy and First Ray Procedures
  17. 490057
    “…Leading a sedentary lifestyle may cause numerous health problems. …”
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    Machine learning and ontology in eCoaching for personalized activity level monitoring and recommendation generation
  18. 490058
    “…Introduction Lung cancer is the most common cancer, and it is the leading cause of cancer-related death. Smoking is the most common risk factor for the development of lung cancer. …”
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    Impact of Comorbidity Scores on the Overall Survival of Patients With Advanced Non-small Cell Lung Cancer: A Real-World Experience From Eastern India
  19. 490059
    “…Codes were assigned to the data and common codes were grouped into categories, leading to themes and subthemes. RESULTS: Of 1600 administered questionnaires, 1580 were returned, giving a 98.75% response rate. …”
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    Pattern and perception of wellbeing, quality of work life and quality of care of health professionals in Southwest Nigeria
  20. 490060
    “…BACKGROUND: Septic arthritis of the hand, which is the second most common after damage of the knee joint, remains one of the leading causes of temporary disability. An inflammation can cause dysfunction of the joint, and in the most severe cases, the need for amputation of the finger may arise. …”
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    Septic arthritis of the hand: From etiopathogenesis to surgical treatment
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