“…Breast cancer remains the second leading cause of cancer-related death in women. Immune-oncology interventions for the treatment of breast cancer have thus far been underwhelming, providing strong rationale for the development of drugs to increase their efficacy. …”
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“…Background: Damage to the hypothalamus via physical trauma, tumors, surgical resection, and/or radiotherapy can impair the melanocortin signaling pathway and reduce energy expenditure, potentially leading to hypothalamic obesity, a severe form of obesity with no current specific therapeutic option. …”
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“…Background: Non-alcoholic fatty liver disease (NAFLD) ranges from steatosis to non-alcoholic steatohepatitis (NASH) cirrhosis, which is the second leading cause of liver transplant in the United States. …”
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“…Background: Lipodystrophy syndromes are rare disorders characterized by selective deficiency of adipose tissue leading to insulin resistance, diabetes mellitus, dyslipidemia and hepatic steatosis. …”
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“…They prompt neurodegeneration leading to accumulations of pathological proteins in AD. …”
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“…BACKGROUND: The prevalence of childhood obesity and overweight has risen globally, leading to increased rates of metabolic disorders. …”
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“…Despite the success of FMT at reducing intestinal MDRO abundance without leading to resistance, FMT composition and efficacy is variable and its safety profile questionable. …”
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“…Figure 1 [Figure: see text] (A) Clinical and demographic characteristics of 222 military health system beneficiaries (COVI D, no PCC: SARS-CoV-2 positive subjects reported no or mild symptoms on 6-month survey; COVID, PCC: SARS-CoV-2 positive subjects reported moderate to severe symptoms on 6-month survey; and Control: SARS-CoV-2 negative subjects), (B) AUROC indicates the ability of leading genes (measured early after infection, TSSK4, TUFT1, and XBP1; which have known association with pulmonary fibrosis, lung cancer, and lymphoma, respectively) which can predict which participants develop PCC versus those who do not, and (C) Identification of biomarker candidates for PCC based on machine learning algorithms. …”
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“…Limitations included overall low event rate limiting power and an open healthcare system leading to possibility of missing hospitalizations due to pts seeking care elsewhere. …”
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“…METHODS: We used date-driven discrete event simulation to evaluate the performance of three leading types of automatic dispensers in four common types of hospitals (Table 1). …”
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“…BACKGROUND: Talaromycosis, an invasive mycosis caused by the Southeast Asian fungus Talaromyces marneffei (Tm) is a leading cause of AIDS-associated death in this region. …”
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“…No deaths, serious adverse events (AEs), Grade 4 AEs, or AEs leading to discontinuation were reported. Most AEs were Grade 1 or 2 and consistent with known safety profiles. …”
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“…BACKGROUND: Human parainfluenza viruses (PIV) are a leading cause of pediatric acute respiratory infection (ARI), yet limited data exist on PIV-associated hospitalizations, particularly from serotype PIV-4, a serotype reported to cause severe disease. …”
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“…Safety endpoints were solicited local and systemic adverse reactions (ARs) up to 7 days after vaccination, unsolicited adverse events (AEs) up to 28 days after vaccination, and serious AEs (SAEs), AEs of special interest (AESIs), medically attended AEs (MAAEs), and AEs leading to study discontinuation. Immunogenicity was measured by hemagglutination inhibition assay. …”
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“…BACKGROUND: Talaromyces marneffei (Tm) is a thermally dimorphic fungus causing invasive mycosis in human immunodeficiency virus (HIV) infected patients in Southeast Asia and is a leading cause of AIDS-related deaths in this region with mortality on anti-fungal therapy as high as 30%. …”
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“…Nutrition counseling probably leads to the initiation of breastfeeding immediately after birth (RR: 1.72; 95% CI, 1.42–2.09, one RCT). …”
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“…BACKGROUND: The deluge of COVID-19 misinformation makes people confused, and acting on such misinformation can kill, leading to the tragic outcome of death. This makes it necessary to identify significant factors associated with college students’ susceptibility. …”
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“…BACKGROUND: Intra-abdominal candidiasis (IAC) is difficult to predict in critically ill patients with intra-abdominal infection, leading to the overuse of antifungal treatments. Serum and peritoneal 1.3-beta-d-glucan (sBDG and pBDG) have been proposed to confirm or invalidate the diagnosis of IAC, but clinical studies have reported inconsistent results, notably because of heterogeneous populations with a low IAC prevalence. …”
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“…CONCLUSION: The findings provide the first evidence that the 5αR activity (leading to the conversion of progesterone to the cancer promoting 5α-pregnanes) is significantly higher in the tumorigenic MCF-7, MDA-MB-231 and T-47D breast cell lines than in the nontumorigenic MCF-10A cell line. …”
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“…An extreme phase of this stage produced by the interference of the rhythms is a temporary standstill of one of the chambers, generally the auricle. The irregularity leads to a lessened efficiency of the work of the heart. …”
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