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490321por Irfan, Furqan B., Consunji, Rafael I. G. D. J., Peralta, Ruben, El-Menyar, Ayman, Dsouza, Landric B., Al-Suwaidi, Jassim M., Singh, Rajvir, Castrén, Maaret, Djärv, Therese, Alinier, Guillaume“…In contrast, OHTCA patients were associated with diffuse blunt non-localizable polytrauma injuries with increased severity leading to immediate cardiac arrest. IHCAT was associated with a higher mean GCS score and a higher rate of initial shockable rhythm and cardiac re-arrest, and improved survival rates.…”
Publicado 2022
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490322por Feys, Simon, Gonçalves, Samuel M., Khan, Mona, Choi, Sumin, Boeckx, Bram, Chatelain, Denis, Cunha, Cristina, Debaveye, Yves, Hermans, Greet, Hertoghs, Marjan, Humblet-Baron, Stephanie, Jacobs, Cato, Lagrou, Katrien, Marcelis, Lukas, Maizel, Julien, Meersseman, Philippe, Nyga, Rémy, Seldeslachts, Laura, Starick, Marick Rodrigues, Thevissen, Karin, Vandenbriele, Christophe, Vanderbeke, Lore, Velde, Greetje Vande, Van Regenmortel, Niels, Vanstapel, Arno, Vanmassenhove, Sam, Wilmer, Alexander, Van de Veerdonk, Frank L., De Hertogh, Gert, Mombaerts, Peter, Lambrechts, Diether, Carvalho, Agostinho, Van Weyenbergh, Johan, Wauters, Joost“…A hampered ability to phagocytize and kill fungal spores enables Aspergillus germination and growth, leading to hyphae that are not contained because of restrained extracellular defense mechanisms. …”
Publicado 2022
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490323por Zhang, Bing, Zhang, Ying, Dang, Wenli, Xing, Bin, Yu, Changxiang, Guo, Pan, Pi, Jiaxin, Deng, Xiuping, Qi, Dongli, Liu, Zhidong“…Meanwhile, toxicity of chemotherapeutic drugs leads to poor tolerance to anti-tumor therapy. The discovery of natural active products antagonizing these toxic side effects offers an avenue for relieving cancer patients’ pain during the treatment process. …”
Publicado 2022
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490324“…We investigated the protective potential of secreted aspartyl proteinase (Sap2), a leading Candidate vaccine antigen identified from research based on C. albicans, in murine systemic candidiasis caused by non-albicans Candida species. …”
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490325“…The exact aetiology is unknown; however, the literature mentions a potential paraneoplastic, inflammatory, infectious or physical trigger, leading to an abnormal response with accumulation of eosinophils in different tissues. …”
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490326por Qin, Yuan, Zhang, Dai, Zhang, Huan, Hou, Lan, Wang, Zhe, Yang, Liu, Zhang, Mingkun, Zhao, Ge, Yao, Qing, Ling, Rui, Zhang, Juliang“…Despite the good prognosis, some THCA patients may deteriorate into more aggressive diseases, leading to poor survival. This may be alleviated by developing a novel model to predict the risk of THCA, including recurrence and survival. …”
Publicado 2022
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490327por Ferjani, H, Kharrat, L, Moalla, M, Triki, W, Ben Nessib, D, Maatallah, K, Kaffel, D, Hamdi, W“…Indeed, active disease seems to affect the child’s appetite and weight gain leading to cachexia [3]. Other studies are needed to confirm these results. …”
Publicado 2022
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490328“…CONCLUSIONS AND IMPLICATIONS: The results of this study suggest that dysarthric speakers due to PD see game‐based speech therapy as a valid alternative for face‐to‐face therapy and that it leads to an average improvement in speech intelligibility. …”
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490329“…INTRODUCTION: The COVID-19 pneumonia is a heterogeneous disease with variable effect on lung parenchyma, airways, and vasculature leading to long-term effects on lung functions. MATERIALS AND METHODS: Multicentric, prospective, observational, and interventional study conducted during July 2020 to May 2021, in the MIMSR Medical College and Venkatesh Hospital Latur India, included 1000 COVID-19 cases confirmed with RT-PCR. …”
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490330“…Binding of adenosine to its receptor A2aR activates a cascade of genes and leads to immunosuppression. In addition, immune checkpoint blockage markedly increases A2aR expression in T cells, which could dampen their anti-tumor response. …”
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490331Publicado 2022“…High systolic blood pressure, tobacco, dietary risks, high fasting plasma glucose, and high BMI were the five leading risks contributing to health loss measured as DALYs in 2019. …”
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490332“…Each layer is characterized by a specific steroidogenic enzyme expression pattern that leads to selective production of mineralocorticoids, glucocorticoids or adrenal androgens. …”
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490333por Shekhar, Skand, Tonleu, Joselyne Tessa, Okigbo, Chinelo C, Leka, Helen, Kim, Anne E, Purse, Bona, Zaccaro, Daneil, Soldin, Steven J, Hirsch, Katie R, Smith-Ryan, Abbie E, Hall, Janet E“…Energy restriction also leads to adaptive changes in metabolic hormones. …”
Publicado 2022
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490334por Kahaly, George, Stan, Marius, Webster, Sara, Liang, Su, Tedeschi, Philip, Janes, Jonathan, Douglas, Raymond“…Batoclimab (IMVT-1401) is an anti-neonatal Fc receptor (FcRn) human monoclonal antibody that prevents normal IgG recycling, leading to reduced levels of circulating IgG. Thus, batoclimab may provide benefit for patients with TED by reducing pathogenic anti-TSHR-Ab. …”
Publicado 2022
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490335por Leboucher, C., Blein, C., Le Maout, A., Machuron, V., Benyounes, K., Le Lay, K., Millier, A., Raffi, Pr“…In this study, requirement for low-flow oxygen support was largely under-reported, due to many reasons: lack of impact of O2 support on stay valorisation, not specified in the registry, and overload of work leading to enter only the most valuable information in the database. …”
Publicado 2022
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490336“…OBJECTIVE: Ovarian cancer has the highest mortality rate among gynecological malignant tumors, and it preferentially metastasizes to omental tissue, leading to intestinal obstruction and death. scRNA-seq is a powerful technique to reveal tumor heterogeneity. …”
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490337por Pisareva, Ekaterina, Mihalovičová, Lucia, Pastor, Brice, Kudriavtsev, Andrei, Mirandola, Alexia, Mazard, Thibault, Badiou, Stephanie, Maus, Ulrich, Ostermann, Lena, Weinmann-Menke, Julia, Neuberger, Elmo W. I., Simon, Perikles, Thierry, Alain R.“…RESULTS: Our studies reveal that gHMW DNA degradation in serum results in the accumulation of mono-N DNA (81.3% of the remaining DNA following 24 h incubation in serum corresponded to mono-N DNA); “ex vivo” NET formation, as demonstrated by a concurrent 5-, 5-, and 35-fold increase of NE, MPO, and cell-free DNA (cfDNA) concentration in PMA-activated neutrophil culture supernatant, leads to the release of high molecular weight DNA that degrades down to mono-N in serum; NET mainly in the form of gHMW DNA generate mono-N cirDNA (2 and 41% of the remaining DNA after 2 h in serum corresponded to 1–10 kbp fragments and mono-N, respectively) independent of any cellular process when degraded in serum; NE and MPO may contribute synergistically to NET autocatabolism, resulting in a 25-fold decrease in total DNA concentration and a DNA fragment size profile similar to that observed from cirDNA following 8 h incubation with both NE and MPO; the cirDNA size profile of NE KO mice significantly differed from that of the WT, suggesting NE involvement in DNA degradation; and a significant increase in the levels of NE, MPO, and cirDNA was detected in plasma samples from lupus, COVID-19, and mCRC, showing a high correlation with these inflammatory diseases, while no correlation of NE and MPO with cirDNA was found in HI. …”
Publicado 2022
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490338por Bowes, Devin A, Driver, Erin M, Kraberger, Simona, Fontenele, Rafaela S, Holland, LaRinda A, Wright, Jillian, Johnston, Bridger, Savic, Sonja, Engstrom Newell, Melanie, Adhikari, Sangeet, Kumar, Rahul, Goetz, Hanah, Binsfeld, Allison, Nessi, Kaxandra, Watkins, Payton, Mahant, Akhil, Zevitz, Jacob, Deitrick, Stephanie, Brown, Philip, Dalton, Richard, Garcia, Chris, Inchausti, Rosa, Holmes, Wydale, Tian, Xiao-Jun, Varsani, Arvind, Lim, Efrem S, Scotch, Matthew, Halden, Rolf U“…A shift in early warning potential of WBE was seen, from a leading (mean of 8·5 days [SD 2·1], June, 2020) to a lagging (−2·0 days [1·4], January, 2021) indicator compared with newly reported clinical cases. …”
Publicado 2023
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490339por Meng, Qingqing, Cohen, Heather, Poudel, Bidhya, Adhikari, Pabitra, Abou-Ghanem, Nagwa, Prasai, Paritosh, Begiashvili, Valiko, Yadav, Kritika, Ozcekirdek, Emre C, Rodriguez Nava, Guillermo, Rodriguez Nava, Guillermo“…BACKGROUND: Hospital-acquired (HA) Clostridioides difficile infection (CDI) is among the most common hospital-acquired infections and is a leading cause of morbidity and mortality among hospitalized older adults. …”
Publicado 2022
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490340por Prakash, Manyu, Grove, Richard, Wynne, Brian R, Man, Choy, van Wyk, Jean A, Jones, Clifford B, Okoli, Chinyere, Letang, Emilio, Ait-Khaled, Mounir, Clark, Andrew“…Across all age groups, proportions of any AEs were similar between the DTG/3TC and CAR groups, with few AEs leading to withdrawal and higher proportions of drug-related AEs with DTG/3TC vs CAR; similar results were observed in the overall population. …”
Publicado 2022
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