“…In mice, the lack of the RNA-binding protein ADAD2 leads to a complete absence of sperm in epididymides due to failure of spemiogenesis, but the spermatogenic effects of ADAD2 mutations in human NOA-associated infertility require functional verification. …”
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“…In addition, the factors leading to different survival status of spCRC and ipCRC were still unclear. …”
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“…These findings may indicate that added occlusion leads to greater muscle utilization, enhancing exercise selection and prescription dependent on the targeted muscle group. …”
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“…In the literature, assessment of weightbearing acetabular coverage has been described using both the sourcil-edge and bone-edge as anatomic landmarks, leading to confusion and controversy in classification of hip dysplasia, indications for hip preservation surgery, and intraoperative coverage assessment. …”
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“…OBJECTIVES: Disagreement exists within the current literature as to whether performing an arthroscopic vs. open subpectoral bicep tenodesis with concomitant arthroscopic rotator cuff repair (ARCR) leads to significantly different outcomes. Therefore, the objective of this study is to use a matched cohort of patients who undergo arthroscopic versus subpectoral biceps repair with concomitant ARCR and assess if there is a significant difference in (Patient-Reported Outcomes Measurement Information System) PROMIS outcomes and the ability to achieve a minimal clinically important difference (MCID). …”
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“…Transient and mostly mild events of neutropenia were observed with secukinumab, none leading to study treatment discontinuation. No incidence of treatment-emergent anti-drug antibodies was reported in pediatric patients treated with secukinumab. …”
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“…Dermatology colleagues were reluctant to re-biopsy due to a high likelihood of non-specific appearances and increased risk of poor healing leading to worsening ulceration. Drawing on experience from rheumatoid arthritis that a switch in anti-TNF biological will often restore efficacy following secondary non-response to adalimumab; we empirically switched treatment to intravenous infliximab, with a reducing course of prednisolone (40mg per day tapering to 5mg after 12 weeks). …”
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“…The mutation of alkaline phosphatase (ALPL) gene leads to wide-ranging clinical manifestations, broadly classified into six different types based on age of onset and severity of the disease. …”
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“…Workup (imaging) identified a bony swelling at the sternoclavicular region leading to referral to our clinic. Our working diagnosis of this being an extremely rare sole manifestation of a common rheumatological disorder was confirmed. …”
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“…Background: Living with obesity negatively impacts a person’s mental health and psychosocial function, leading to impaired health-related quality of life (HRQoL). …”
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“…At week 72, MMRM-estimated relative change in risk from baseline was -16.4%, -23.5%, -22.4%, and 12.7% for TZP 5/10/15mg and PBO, leading to significantly greater reduction for TZP groups compared to PBO (TZP 5 mg: -25.8%; 10 mg: -32.1%; 15 mg: -31.1%; p≤0.001). …”
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“…It is associated with excessive activation of the immune system and hypercytokinemia, leading to an unregulated aggregation of macrophages and lymphocytes. …”
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“…In this study, we have tried to shed some light on the molecular mechanisms leading to extravascular fibrin deposition, using two well-established mouse models of RA: AIA and CIA. …”
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“…The experiments finally prove that a relatively high degree of active immunity can be induced by a harmless procedure, whereas the use of toxin alone leading to very severe local lesions is incapable of producing more than an insignificant protection. …”
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“…From such intermediate results all kinds of gradations exist, leading on one side to dominance of the strain with the higher tumor rate and on the other side to dominance of the strain with the lower tumor rate. …”
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“…In all eleven countries included (Austria, Australia, Canada, Switzerland, Finland, France, the Netherlands, Norway, New Zealand, Sweden, and the United Kingdom) a drug's therapeutic benefit in comparison to treatment alternatives is leading the evaluation. A medicine is classified as a therapeutic improvement if it demonstrates an improved benefit-/risk-profile compared to treatment alternatives. …”
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“…It is a time for sequencing entire genomes and deliberately silencing relevant segments of the mouse genome to see what each segment controls and if that silencing leads to increased susceptibility to disease. What remains to be charted in this genomic era is the complex interaction of genes, gene segments, post-translational modifications of encoded proteins, and environmental factors that affect genomic expression. …”
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“…Although the actual mechanisms involved in hair shedding are not fully known, it has been hypothesized that the processes leading to the final step of hair shedding may be driven by proteases and/or protease inhibitor activity. …”
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“…OBJECTIVES: Ageing leads to characteristic changes in the appearance of facial skin. …”
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“…An automated 360-degree software process may be a faster, simpler, and less resource-intensive approach than telephoning and interviewing patients for survey responses, and it potentially could facilitate a more rapid credentialing or quality improvement process leading to greater fiscal and professional development gains for physicians. …”
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