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490441por Sadler, Euan, Khadjesari, Zarnie, Ziemann, Alexandra, Sheehan, Katie J, Whitney, Julie, Wilson, Dan, Bakolis, Ioannis, Sevdalis, Nick, Sandall, Jane, Soukup, Tayana, Corbett, Teresa, Gonçalves-Bradley, Daniela C, Walker, Dawn-Marie“…The British Geriatrics Society defines frailty as "a distinctive health state related to the ageing process in which multiple body systems gradually lose their inbuilt reserves". This leads to an increased susceptibility to adverse outcomes, such as reduced physical function, poorer quality of life, hospital admissions, and mortality. …”
Publicado 2023
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490442por Alexander, Rachel, Sleiman, Marc, Lee, Cody, He, Tong-Chuan, Athiviraham, Aravind, Acheampong, Kofi“…These results together suggest that TGF-β1 gene therapy may enhance meniscus healing by inducing more cellular proliferation and infiltration and greater neovascularization at the injury site to serve as nourishment for the establishment of new wound matrix, leading to more significant deposition and remodeling of mature collagen matrix. …”
Publicado 2023
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490443por LeVasseur, Clarissa, Johnson, Camille, Curley, Andrew, Ruh, Ethan, Fuentes, Kathleen, Mauro, Craig, Anderst, William, McClincy, Michael, Charles, Shaquille“…OBJECTIVES: Femoroacetabular impingement syndrome (FAIS) is classically described as cam, pincer, or mixed morphology, leading to pathologic osseous contact between the femur and acetabulum (Beck JBJS). …”
Publicado 2023
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490444“…FAI syndrome occurs when irregularities in femoral and acetabular anatomy create abnormal contact forces across the joint, leading to labral and chondral damage. These anatomical irregularities are categorised into three morphologies: cam (an aspherical femur head resulting in superior acetabulum impingement), pincer (over-coverage of the femoral head by the acetabulum) and mixed. …”
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490445“…Rheumatoid nodules most commonly occur subcutaneously, and are due to an intense inflammatory process causing fibrinoid necrosis and macrophage activation, leading to an immune-mediated granuloma. Rheumatoid nodules have a prevalence of < 0.4% in radiological studies to 32% in lung biopsies, and are usually commoner in males with positive rheumatoid factor, smokers, and in those with skin nodules and long-term methotrexate. …”
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490446por Bourdeau, Malou, Vadlamudi, Nirma K, Bancej, Christina, Bastien, Nathalie, Embree, Joanne, Halperin, Scott, Hudgin, Andrea, Jadavji, Taj, Kazmi, Kescha, Langley, Joanne M, Lebel, Marc, Le Saux, Nicole, Moore, Dorothy L, Morris, Shaun, Pernica, Jeffrey, Robinson, Joan, Sadarangani, Manish, Bettinger, Julie A, Papenburg, Jesse“…BACKGROUND: Respiratory syncytial virus (RSV) is a leading cause of pediatric hospitalizations. We aimed to describe the epidemiology and burden of RSV-associated hospitalizations among children in Canadian pediatric centers from 2017 to 2022, including changes during the COVID-19 pandemic. …”
Publicado 2023
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490447por Tak, Paul P, Klapwijk, Maartje S, Broersen, Sophie FM, van de Geest, Deliana A, Overbeek, Marieke, Firestein, Gary S“…Overexpression of p53 and increased numbers of apoptotic cells did not occur simultaneously in this model; rather p53 overexpression preceded increased apoptosis. Activation of p53 leads to induction of cell growth arrest, allowing time for DNA repair. …”
Publicado 2000
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490448“…Autoradiographs indicated that DNA synthesis by -OG cells normally proceeds at an intense level that leads to some 60% of these cells being heavily labeled in autoradiographs at any given time; after exposure to the effects of heated guinea pig serum during 2 and 4 hr in vivo, however, the lymphoma cells lost their ability to incorporate enough tritiated thymidine to become heavily labeled, but approximately the same proportion of them (56 to 58%) retained their ability to incorporate sufficient tritiated thymidine to become lightly labeled. …”
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490449por Segré, C“…On top of everything, we had the pleasure of inviting, as keynote speakers, two leading European scientists in the fields of cancer invasion and biology of stem cells, respectively: Dr Peter Friedl from The Nijmegen Centre for Molecular Life (The Netherlands) and Professor Andreas Trumpp from The Heidelberg Institute for Stem Cell Technology and Experimental Medicine (Heidelberg). …”
Publicado 2010
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490450por Quaedvlieg, W., Verkley, G.J.M., Shin, H.-D., Barreto, R.W., Alfenas, A.C., Swart, W.J., Groenewald, J.Z., Crous, P.W.“…A total of 47 clades or genera were resolved, leading to the introduction of 14 new genera, 36 new species, and 19 new combinations. …”
Publicado 2013
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490451por Bagci, Ulas, Foster, Brent, Miller-Jaster, Kirsten, Luna, Brian, Dey, Bappaditya, Bishai, William R, Jonsson, Colleen B, Jain, Sanjay, Mollura, Daniel J“…BACKGROUND: Infectious diseases are the second leading cause of death worldwide. In order to better understand and treat them, an accurate evaluation using multi-modal imaging techniques for anatomical and functional characterizations is needed. …”
Publicado 2013
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490452por Wiysonge, Charles S, Bradley, Hazel A, Volmink, Jimmy, Mayosi, Bongani M, Opie, Lionel H“…Current evidence suggests that initiating treatment of hypertension with beta‐blockers leads to modest CVD reductions and little or no effects on mortality. …”
Publicado 2017
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490453por Macdonald, Joni, Kilcoyne, Karen R, Sharpe, Richard M, Kavanagh, Áine, Anderson, Richard A, Brown, Pamela, Smith, Lee B, Jørgensen, Anne, Mitchell, Rod T“…SUMMARY ANSWER: DMRT1 repression in human fetal testis alters the expression of key testicular and ovarian determining genes, and leads to focal testicular dysgenesis. WHAT IS KNOWN ALREADY: Testicular dysgenesis syndrome (TDS) is associated with common testicular disorders in young men, but its etiology is unknown. …”
Publicado 2018
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490454por Kotloff, Karen L, Nasrin, Dilruba, Blackwelder, William C, Wu, Yukun, Farag, Tamer, Panchalingham, Sandra, Sow, Samba O, Sur, Dipika, Zaidi, Anita K M, Faruque, Abu S G, Saha, Debasish, Alonso, Pedro L, Tamboura, Boubou, Sanogo, Doh, Onwuchekwa, Uma, Manna, Byomkesh, Ramamurthy, Thandavarayan, Kanungo, Suman, Ahmed, Shahnawaz, Qureshi, Shahida, Quadri, Farheen, Hossain, Anowar, Das, Sumon K, Antonio, Martin, Hossain, M Jahangir, Mandomando, Inacio, Acácio, Sozinho, Biswas, Kousick, Tennant, Sharon M, Verweij, Jaco J, Sommerfelt, Halvor, Nataro, James P, Robins-Browne, Roy M, Levine, Myron M“…BACKGROUND: Diarrheal diseases remain a leading cause of illness and death among children younger than 5 years in low-income and middle-income countries. …”
Publicado 2019
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490455por Kaplan, Gilaad G, Bernstein, Charles N, Coward, Stephanie, Bitton, Alain, Murthy, Sanjay K, Nguyen, Geoffrey C, Lee, Kate, Cooke-Lauder, Jane, Benchimol, Eric I“…The causes of IBD are unknown, but the high rates of disease over the past 60 years in Western countries and the emergence of disease in developing countries suggest that factors associated with urbanization, modernization, or Western diets may be pertinent to understanding the pathogenesis of the disease. 5. Many of the leading hypotheses as to the causes of IBD tie in with alteration of the gut microbiome, the suite of organisms that reside in the bowel and maintain bowel health throughout life. …”
Publicado 2019
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490456“…When the lungs are affected, the severity and extent of lung damage generally determines the prognosis because respiratory failure is the leading cause of death. Clinical presentation guides towards therapeutic management that mostly includes corticosteroids, immunosuppressive medications, and/or physical therapy KEY LEARNING POINTS: Digital ischemia could be a rare presentation of ASS. …”
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490457“…It is also our hope that by increasing URMs in the workforce, there will be positive impact on communities of color, with respect to increasing participation in their health care decision making and in clinical/translational research; thus, ultimately leading to better health outcomes in the communities we live and serve. …”
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490458“…Odds of linkage failure were decreased among patients with known linkage barriers including mental health disorders (adjusted odds ratio [aOR], 0.28; 95% confidence interval [CI], 0.21-0.37), active substance abuse (aOR, 0.65; 95% CI, 0.47-0.91), and ‘competing’ medical comorbidities (aOR, 0.31; 95% CI, 0.21-0.47); however, odds of linkage failure were increased in the presence of medical comorbidities leading to ineligibility for HCV treatment (aOR, 21.71; 95% CI, 7.02-67.13). …”
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490459por Aljahdali, Anan, Airina, R K Raja Ili, Velazquez, Miguel A, Sheth, Bhavwanti, Wallen, Katrina, Osmond, Clive, Watkins, Adam J, Eckert, Judith J, Smyth, Neil R, Fleming, Tom P“…WIDER IMPLICATIONS OF THE FINDINGS: The study indicates that longer duration of embryo culture after IVF up to blastocyst before ET leads to increased dysfunction of CV health in males compared with IVF and shorter cleavage-stage ET. …”
Publicado 2020
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490460“…Electrocardiogram showed new T-wave inversion in the anterolateral leads with significantly raised troponin levels. …”
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